{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:55:30Z","timestamp":1771487730570,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4529,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.fertnstert.2009.02.070","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T04:15:18Z","timestamp":1239768918000},"page":"609-615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Optimizing embryo selection with day 5 transfer"],"prefix":"10.1016","volume":"93","author":[{"given":"Andrea","family":"Reh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Fino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Krey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Berkeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Noyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Grifo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2009.02.070_bib1","first-page":"323","article-title":"ACOG educational bulletin. Special problems of multiple gestation","volume":"64","year":"1999","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1067\/mpd.2000.105132","article-title":"Effects of in vitro fertilization on low birth weight, preterm delivery, and multiple birth","volume":"136","author":"Tough","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib3","series-title":"Elective single embryo transfer: guidelines for practice. British Fertility Society and Association of Clinical Embryologists","author":"Cutting","year":"2008"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib4","first-page":"709","article-title":"Assessment of risk factors for preterm birth. Clinical management guidelines for obstetrician-gynecologists","volume":"98","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib5","first-page":"97","article-title":"Use of assisted reproductive technology\u2014United States, 1996 and 1998","volume":"51","year":"2002","journal-title":"MMWR"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib6","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0022-3476(95)70175-3","article-title":"Maternal and neonatal morbidity associated with in vitro fertilization","volume":"127","author":"Tallo","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib7","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/humrep\/15.8.1856","article-title":"Multiple gestation pregnancy","volume":"15","year":"2000","journal-title":"Hum Reprod"},{"issue":"4 Suppl","key":"10.1016\/j.fertnstert.2009.02.070_bib8","doi-asserted-by":"crossref","first-page":"s29","DOI":"10.1038\/ncb-nm-fertilityS29","article-title":"The economic impact of the assisted reproductive technologies","author":"Katz","year":"2002","journal-title":"Nat Cell Bio"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib9","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.fertnstert.2007.07.1360","article-title":"Redefining in vitro fertilization success: should triplets be considered failures?","volume":"90","author":"Grunfeld","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib10","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1093\/humrep\/15.7.1619","article-title":"Multifetal reduction of triplets to twins: a prospective comparison of pregnancy outcome","volume":"15","author":"Boulot","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/jmf.16.4.219.222","article-title":"Embryo reduction versus expectant management in triplet pregnancies","volume":"16","author":"Antsaklis","year":"2004","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/pd.1261","article-title":"Update on selective reduction","volume":"25","author":"Evans","year":"2005","journal-title":"Prenat Diag"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib13","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1093\/humrep\/del048","article-title":"Risks of miscarriage and early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review","volume":"21","author":"Papageorghiou","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1515\/jpme.1998.26.5.365","article-title":"Should multifetal pregnancy reduction be used for prevention of preterm deliveries in triplet or higher order multiple pregnancies?","volume":"26","author":"Papiernik","year":"1998","journal-title":"J Perinat Med"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib15","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1093\/humrep\/14.8.2170","article-title":"Obstetric outcome and psychological follow-up of pregnancies after embryo reduction","volume":"14","author":"Bergh","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.fertnstert.2006.09.016","article-title":"Assisted reproductive technology practice patterns and the impact of embryo transfer guidelines in the United States","volume":"88","author":"Stern","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib17","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.fertnstert.2006.07.1473","article-title":"Guidelines on number of embryos transferred","volume":"86","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0015-0282(97)00438-X","article-title":"Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers","volume":"69","author":"Gardner","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.fertnstert.2006.10.005","article-title":"Programmatic implementation of blastocyst transfer in a university-based in vitro fertilization clinic: maximizing pregnancy rates and minimizing triplet rates","volume":"88","author":"Grifo","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002118.pub3","article-title":"Cleavage stage versus blastocyst stage embryo transfer in assisted conception","volume":"4","author":"Blake","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1472-6483(10)60981-9","article-title":"Early pregnancy loss is significantly higher after day 3 single embryo transfer than after day 5 single blastocyst transfer in GnRH antagonist stimulated IVF cycles","volume":"12","author":"Papanikolaou","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib22","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1093\/humrep\/deh447","article-title":"Should we advise patients undergoing IVF to start a cycle leading to a day 3 or a day 5 transfer?","volume":"19","author":"Kolibianakis","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib23","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.fertnstert.2003.08.031","article-title":"Blastocyst-stage embryo transfer in patients who failed to conceive in three or more day 2\u20133 embryo transfer cycles: a prospective, randomized study","volume":"81","author":"Levitas","year":"2004","journal-title":"Fertil Steril"},{"issue":"Suppl B","key":"10.1016\/j.fertnstert.2009.02.070_bib24","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0143-4004(03)00172-3","article-title":"Implantation rates after two, three, or five days of embryo culture","volume":"24","author":"de los Santos","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib25","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/humrep\/deh398","article-title":"Pregnancy outcome after blastocyst transfer as compared to early cleavage stage embryo transfer","volume":"19","author":"Schwarzler","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib26","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/humrep\/14.6.1405","article-title":"Blastocyst stage transfer: pitfalls and benefits. The benefits of extended culture","volume":"14","author":"Jones","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib27","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa053524","article-title":"In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos","volume":"354","author":"Papanikolaou","year":"2006","journal-title":"New Engl J Med"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/humrep\/dem339","article-title":"Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis","volume":"23","author":"Papanikolaou","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib29","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/humrep\/17.6.1507","article-title":"A prospective randomized study: day 2 versus day 5 embryo transfer","volume":"17","author":"Van der Auwera","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib30","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1093\/humrep\/dei217","article-title":"Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study","volume":"20","author":"Papanikolaou","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib31","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0015-0282(99)00121-1","article-title":"Influence of advanced age on the blastocyst development rate and pregnancy rate in assisted reproductive technology","volume":"71","author":"Pantos","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0015-0282(02)04558-2","article-title":"Blastocyst transfer decreases multiple pregnancy rates in in vitro fertilization cycles: a randomized controlled trial","volume":"79","author":"Frattarelli","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0015-0282(99)00565-8","article-title":"The number of eight-cell embryos is a key determinant for selecting day 3 or day 5 transfer","volume":"73","author":"Racowsky","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejogrb.2004.06.011","article-title":"Embryo transfer is equally effective at cleavage stage and blastocyst stage: a randomized prospective study","volume":"117","author":"Hreinsson","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib35","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/humrep\/17.7.1852","article-title":"Day 3 embryo transfer with combined evaluation at the pronuclear and cleavage stages compares favourably with day 5 blastocyst transfer","volume":"17","author":"Rienzi","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib36","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1093\/humrep\/15.9.1947","article-title":"Day 5 versus day 3 embryo transfer: a controlled randomized trial","volume":"15","author":"Coskun","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib37","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/humrep\/deg394","article-title":"Similar delivery rates in a selected group of patients, for day 2 and day 5 embryos both cultured in sequential medium: a randomized study","volume":"18","author":"Emiliani","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib38","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1472-6483(10)61736-1","article-title":"Day 3 versus day 5 embryo transfer: a prospective randomized study","volume":"7","author":"Bungum","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib39","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/S0015-0282(02)03090-X","article-title":"A prospective randomized study comparing day 3 with blastocyst-stage embryo transfer","volume":"77","author":"Levron","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib40","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/0002-9378(72)90792-2","article-title":"A simple nonsurgical technique to obtain unimplanted eggs from human uteri","volume":"112","author":"Croxatto","year":"1972","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib41","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0015-0282(01)02018-0","article-title":"Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo","volume":"76","author":"Valbuena","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0015-0282(16)58097-2","article-title":"Environment of the preimplantation human embryo in vivo: metabolite analysis of oviduct and uterine fluids and metabolism of cumulus cells","volume":"65","author":"Gardner","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib43","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/humrep\/16.6.1115","article-title":"Uterine contractility decreases at the time of blastocyst transfers","volume":"16","author":"Fanchin","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib44","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1093\/humrep\/13.10.2869","article-title":"The predictive value of day 3 embryo morphology regarding blastocyst formation, pregnancy and implantation rate after day 5 transfer following in-vitro fertilization or intracytoplasmic sperm injection","volume":"13","author":"Rijnders","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib45","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0015-0282(00)00689-0","article-title":"Day 3 morphology is a poor predictor of blastocyst quality in extended culture","volume":"74","author":"Graham","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib46","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/humrep\/15.8.1781","article-title":"Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro","volume":"15","author":"Magli","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.02.070_bib47","unstructured":"Reh A, Krey L, Noyes N. Are gonadotropin-releasing hormone agonists losing popularity? Current trends at a large fertility center. Fertil Steril. Published online October 28, 2008 [Epub ahead of print]."}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820900497X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820900497X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:38:36Z","timestamp":1758008316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001502820900497X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S001502820900497X"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2009.02.070","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimizing embryo selection with day 5 transfer","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2009.02.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}