{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:25:24Z","timestamp":1767896724867,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4225,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.fertnstert.2009.11.049","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T04:51:51Z","timestamp":1264481511000},"page":"2214-2221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The determinants of insulin sensitivity, \u03b2-cell function, and glucose tolerance are different in patients with polycystic ovary syndrome than in women who do not have hyperandrogenism"],"prefix":"10.1016","volume":"94","author":[{"given":"Manuel","family":"Luque-Ram\u00edrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macarena","family":"Alpa\u00f1\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor F.","family":"Escobar-Morreale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2009.11.049_bib1","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1210\/jc.2007-1549","article-title":"Glucose intolerance in polycystic ovary syndrome\u2014a position statement of the Androgen Excess Society","volume":"92","author":"Salley","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.22.1.141","article-title":"Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome","volume":"22","author":"Ehrmann","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib3","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib4","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib5","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1172\/JCI118064","article-title":"Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus","volume":"96","author":"Ehrmann","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/er.2004-0004","article-title":"The molecular\u2013genetic basis of functional hyperandrogenism and the polycystic ovary syndrome","volume":"26","author":"Escobar-Morreale","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tem.2007.07.003","article-title":"Abdominal adiposity and the polycystic ovary syndrome","volume":"18","author":"Escobar-Morreale","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib8","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1093\/humrep\/del146","article-title":"Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study","volume":"21","author":"Escobar-Morreale","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib9","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2337\/diabetes.51.9.2734","article-title":"Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein","volume":"51","author":"Nishizawa","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib10","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2337\/dc09-0420","article-title":"Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance and genomic variants related to inflammation, oxidative stress and iron metabolism","volume":"32","author":"Martinez-Garcia","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib11","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.2337\/diabetes.51.8.2348","article-title":"Cross-talk between iron metabolism and diabetes","volume":"51","author":"Fernandez-Real","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib12","series-title":"Polycystic ovary syndrome. Vol. 4","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","author":"Zawadzki","year":"1992"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib13","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1210\/jc.2007-2053","article-title":"A prospective study of the prevalence of nonclassic congenital adrenal hyperplasia (NCAH) among women presenting hyperandrogenic symptoms and signs","volume":"93","author":"Escobar-Morreale","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib14","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib15","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2337\/diacare.17.2.152","article-title":"A mathematical model for the determination of total area under glucose tolerance and other metabolic curves","volume":"17","author":"Tai","year":"1994","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib17","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/oby.2008.307","article-title":"Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test","volume":"16","author":"Retnakaran","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib18","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc09-S062","article-title":"Position Statement. Diagnosis and classification of diabetes mellitus","volume":"32","author":"American Diabetes Association","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib19","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.2337\/diabetes.53.9.2353","article-title":"Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors","volume":"53","author":"Gambineri","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib20","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/dc06-1331","article-title":"What is the best predictor of future type 2 diabetes?","volume":"30","author":"Abdul-Ghani","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.33549\/physiolres.931275","article-title":"Family history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome","volume":"57","author":"Vrbikova","year":"2008","journal-title":"Physiol Res"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib22","doi-asserted-by":"crossref","DOI":"10.2337\/dc08-1690","article-title":"Serum visceral adipose tissue-derived serine protease inhibitor concentrations in human obesity and polycystic ovary syndrome","volume":"32","author":"Escobar-Morreale","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib23","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1042\/BJ20082033","article-title":"Adiponectin: no longer the lone soul in the fight against insulin resistance?","volume":"416","author":"Davis","year":"2008","journal-title":"Biochem J"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2002-0010","article-title":"Insulin resistance and chronic cardiovascular inflammatory syndrome","volume":"24","author":"Fernandez-Real","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance","volume":"271","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib26","doi-asserted-by":"crossref","first-page":"21839","DOI":"10.1016\/S0021-9258(18)54714-1","article-title":"Transcriptional repression of the GLUT4 and C\/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha","volume":"266","author":"Stephens","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2009.11.049_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000115360","article-title":"The beta-cell in type 2 diabetes and in obesity","volume":"36","author":"Rutter","year":"2008","journal-title":"Front Horm Res"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820904134X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502820904134X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:45:43Z","timestamp":1758008743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001502820904134X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S001502820904134X"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2009.11.049","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The determinants of insulin sensitivity, \u03b2-cell function, and glucose tolerance are different in patients with polycystic ovary syndrome than in women who do not have hyperandrogenism","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2009.11.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}