{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:48:56Z","timestamp":1772192936495,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4195,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.fertnstert.2010.02.048","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T02:04:41Z","timestamp":1271037881000},"page":"2654-2658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Endothelial function in patients with polycystic ovary syndrome: a long-term follow-up study"],"prefix":"10.1016","volume":"94","author":[{"given":"Miriam","family":"Hudecova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Holte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matts","family":"Olovsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Lind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger Sundstr\u00f6m","family":"Poromaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2010.02.048_bib1","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1210\/jc.2004-2279","article-title":"Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters","volume":"90","author":"Carmina","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.amjmed.2005.10.059","article-title":"Endothelial dysfunction in PCOS: role of obesity and adipose hormones","volume":"119","author":"Carmina","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib3","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2459\/JCM.0b013e32830b58d4","article-title":"Cardiovascular risk in women with polycystic ovary syndrome","volume":"9","author":"Giallauria","year":"2008","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib4","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1210\/jc.2005-2430","article-title":"Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome","volume":"91","author":"Lo","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib5","first-page":"27","article-title":"Do women with polycystic ovary syndrome have an increased risk of cardiovascular disease? Review of the evidence","volume":"56","author":"Talbott","year":"2004","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/er.2003-0004","article-title":"Polycystic ovary syndrome and cardiovascular disease: a premature association?","volume":"24","author":"Legro","year":"2003","journal-title":"Endocrinol Rev"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/00016349209006227","article-title":"Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women","volume":"71","author":"Dahlgren","year":"1992","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/humrep\/15.4.785","article-title":"Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome","volume":"15","author":"Cibula","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2265.2000.01000.x","article-title":"Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study","volume":"52","author":"Wild","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0895-4356(98)00035-3","article-title":"Mortality of women with polycystic ovary syndrome at long-term follow-up","volume":"51","author":"Pierpoint","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib11","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1210\/jc.2007-0425","volume":"93","author":"Shaw","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib12","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.4158\/EP.14.9.1084","article-title":"Risk of cardiovascular events in mothers of women with polycystic ovary syndrome","volume":"14","author":"Cheang","year":"2008","journal-title":"Endocrinol Pract"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib13","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1471-0528.2006.01090.x","article-title":"Flow-mediated dilatation in overweight and obese women with polycystic ovary syndrome","volume":"113","author":"Brinkworth","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib14","first-page":"1851","article-title":"Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome","volume":"85","author":"Mather","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib15","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1210\/jc.2005-0151","article-title":"Predictors of endothelial dysfunction in young women with polycystic ovary syndrome","volume":"90","author":"Kravariti","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib16","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1210\/jc.2005-0011","article-title":"Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease","volume":"90","author":"Meyer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib17","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1210\/jc.2003-031867","article-title":"Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome","volume":"89","author":"Orio","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib18","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1210\/jc.2004-0751","article-title":"Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation","volume":"89","author":"Tarkun","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/CS20080218","article-title":"A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome","volume":"116","author":"Moran","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1046\/j.1475-097X.2003.00469.x","article-title":"Analysis of endothelium-dependent vasodilation by use of the radial artery pulse wave obtained by applanation tonometry","volume":"23","author":"Lind","year":"2003","journal-title":"Clin Physiol Funct Imaging"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib21","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1161\/01.ATV.0000184769.22061.da","article-title":"A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study","volume":"25","author":"Lind","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0735-1097(02)01991-5","article-title":"Assessment of endothelial function using peripheral waveform analysis: a clinical application","volume":"40","author":"Hayward","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/hq0102.101770","article-title":"Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function","volume":"22","author":"Wilkinson","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.atherosclerosis.2007.01.014","article-title":"Endothelium-dependent vasodilation, insulin resistance and the metabolic syndrome in an elderly cohort: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study","volume":"196","author":"Lind","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib25","first-page":"1","article-title":"Long-term follow-up of patients with polycystic ovary syndrome: reproductive outcome and ovarian reserve","volume":"1","author":"Hudecova","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-2265.1994.tb02578.x","article-title":"The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women","volume":"41","author":"Holte","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/bmj.293.6543.355","article-title":"Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism","volume":"293","author":"Adams","year":"1986","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib28","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s001250051561","article-title":"Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test","volume":"43","author":"Albareda","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib29","first-page":"1052","article-title":"Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance","volume":"78","author":"Holte","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib30","first-page":"2586","article-title":"Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome","volume":"80","author":"Holte","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib31","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1172\/JCI118709","article-title":"Obesity\/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance","volume":"97","author":"Steinberg","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.ijo.0802642","article-title":"Vascular endothelial dysfunction tested by blunted response to endothelium-dependent vasodilation by salbutamol and its related factors in uncomplicated pre-menopausal obese women","volume":"29","author":"Suh","year":"2005","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2337\/diabetes.50.1.159","article-title":"Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C","volume":"50","author":"Perticone","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib34","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/sj.ijo.0801022","article-title":"Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity","volume":"23","author":"Arcaro","year":"1999","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib35","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0002-9149(01)02088-4","article-title":"Usefulness of visceral obesity (waist\/hip ratio) in predicting vascular endothelial function in healthy overweight adults","volume":"88","author":"Brook","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3349\/ymj.2005.46.4.511","article-title":"Reduction in visceral adiposity is highly related to improvement in vascular endothelial dysfunction among obese women: an assessment of endothelial function by radial artery pulse wave analysis","volume":"46","author":"Park","year":"2005","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib37","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/j.atherosclerosis.2006.09.010","article-title":"Vasodilation and visceral fat in elderly subjects: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study","volume":"194","author":"Lind","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib38","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1530\/eje.1.01910","article-title":"Metformin administration improves endothelial function in women with polycystic ovary syndrome","volume":"152","author":"Diamanti-Kandarakis","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib39","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1210\/jc.2002-020386","article-title":"Troglitazone therapy improves endothelial function to near normal levels in women with polycystic ovary syndrome","volume":"88","author":"Paradisi","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1530\/EJE-08-0507","article-title":"Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome","volume":"159","author":"Jensterle","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib41","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1093\/humrep\/den230","article-title":"Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective","volume":"23","author":"Romualdi","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.02.048_bib42","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/HYPERTENSIONAHA.109.137703","article-title":"Arterial wave reflections during the menstrual cycle of healthy women: a reproducibility study","volume":"54","author":"Papaioannou","year":"2009","journal-title":"Hypertension"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210003419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210003419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:48:45Z","timestamp":1758008925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028210003419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0015028210003419"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.02.048","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial function in patients with polycystic ovary syndrome: a long-term follow-up study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.02.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}