{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:14:37Z","timestamp":1762150477912,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4164,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2009SGR-01107","2005FI00399"],"award-info":[{"award-number":["2009SGR-01107","2005FI00399"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.fertnstert.2010.06.042","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T05:22:21Z","timestamp":1280812941000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Meiotic chromosome abnormalities in fertile men: are they increasing?"],"prefix":"10.1016","volume":"95","author":[{"given":"Laia","family":"Uroz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Rajmil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Templado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 4","key":"10.1016\/j.fertnstert.2010.06.042_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humrep\/11.suppl_4.1","article-title":"Cytogenetics of infertile men","volume":"11","author":"Van Assche","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib2","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1093\/humrep\/17.10.2600","article-title":"Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters","volume":"17","author":"Bonduelle","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/humrep\/14.2.375","article-title":"Meiotic abnormalities and spermatogenic parameters in severe oligoasthenozoospermia","volume":"14","author":"Vendrell","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib4","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0015-0282(00)01551-X","article-title":"A simple and reliable method for meiotic studies on testicular samples used for intracytoplasmic sperm injection","volume":"74","author":"Metzler-Guillemain","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib5","article-title":"Les chromosomes m\u00e9iotiques de l'homme. I. La m\u00e9iose normale","volume":"13","author":"Luciani","year":"1970","journal-title":"Ann Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/jrf.0.0350023","article-title":"Studies on meiotic chromosomes in infertile men and controls with normal karyotypes","volume":"35","author":"Skakkebaek","year":"1973","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1469-1809.1976.tb00176.x","article-title":"Cytogenetics and infertility in man. II. Testicular histology and meiosis","volume":"40","author":"Chandley","year":"1976","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00286660","article-title":"Meiotic studies in a series of 1100 infertile and sterile males","volume":"65","author":"Egozcue","year":"1983","journal-title":"Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1469-1809.1985.tb01693.x","article-title":"Further studies on bivalent chiasma frequency in human males with normal karyotypes","volume":"49","author":"Laurie","year":"1985","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1601-5223.1970.tb02327.x","article-title":"Low chiasma count and other meiotic irregularities in two infertile 46, XY men with spermatogenic arrest","volume":"65","author":"Hult\u00e9n","year":"1970","journal-title":"Hereditas"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1601-5223.1974.tb01433.x","article-title":"Abnormal synaptonemal complex in an oligochiasmatic man with spermatogenic arrest","volume":"78","author":"Hult\u00e9n","year":"1974","journal-title":"Hereditas"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib12","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1159\/000130115","article-title":"A gross reduction in chiasma formation during meiotic prophase and a defective DNA repair mechanism associated with a case of human male infertility","volume":"9","author":"Pearson","year":"1970","journal-title":"Cytogenetics"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib13","first-page":"49","article-title":"Anomalies mei\u00f3tiques et gam\u00e9tiques multiples dans un cas de st\u00e9rilit\u00e9 masculine","volume":"14","author":"Dutrillaux","year":"1971","journal-title":"Ann Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1399-0004.1974.tb01673.x","article-title":"Chromosomes and human infertility. I. Mitotic and meiotic chromosome studies in 202 consecutive male patients","volume":"5","author":"Koulischer","year":"1974","journal-title":"Clin Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1439-0272.1976.tb01657.x","article-title":"Three cases of low chiasma frequency associated with infertility in man","volume":"8","author":"Templado","year":"1976","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib16","first-page":"833","article-title":"Genetically determined asynapsis, spermatogenic degeneration, and infertility in men","volume":"32","author":"Chaganti","year":"1980","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000086907","article-title":"Meiotic abnormalities in infertile males","volume":"111","author":"Egozcue","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF00295469","article-title":"A new meiotic mutation: desynapsis of individual bivalents","volume":"59","author":"Templado","year":"1981","journal-title":"Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1051\/rnd:19780307","article-title":"Meiotic disturbances related to human male sterility","volume":"18","author":"Luciani","year":"1978","journal-title":"Ann Biol Anim Bioch Biophys"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib20","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/humrep\/dep092","article-title":"Centromere-specific multicolour fluorescence in situ hybridization on human spermatocyte I and II metaphases","volume":"24","author":"Uroz","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000129818","article-title":"An air-drying method for meiotic preparations from mammalian testes","volume":"15","author":"Evans","year":"1964","journal-title":"Cytogenetics"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib22","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/humrep\/dem427","article-title":"Premature separation of sister chromatids in human male meiosis","volume":"23","author":"Uroz","year":"2008","journal-title":"Hum Reprod"},{"year":"2009","author":"Schaffer","series-title":"ISCN: an international system for human cytogenetic nomenclature","key":"10.1016\/j.fertnstert.2010.06.042_bib23"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib24","series-title":"Genetic control of gamete production and function","first-page":"239","article-title":"Meiotic chromosome studies in human male infertility","author":"Koulischer","year":"1982"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib25","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1093\/humrep\/del190","article-title":"Analysis of non-crossover bivalents in pachytene cells from 10 normal men","volume":"21","author":"Sun","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000086890","article-title":"Frequency and distribution of chromosome abnormalities in human spermatozoa","volume":"111","author":"Templado","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000086896","article-title":"Effect of meiotic recombination on the production of aneuploid gametes in humans","volume":"111","author":"Lamb","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib29","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/ng2120","article-title":"The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere","volume":"39","author":"Lacefield","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000132500","article-title":"An analysis of structural aberrations in human sperm chromosomes","volume":"47","author":"Brandriff","year":"1988","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib31","first-page":"452","article-title":"An analysis of human sperm chromosome breakpoints","volume":"56","author":"Estop","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0168-9525(00)02080-1","article-title":"The pachytene checkpoint","volume":"16","author":"Roeder","year":"2000","journal-title":"Trends Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.theriogenology.2007.09.029","article-title":"Disruption of pairing and synapsis of chromosomes causes stage-specific apoptosis of male meiotic cells","volume":"69","author":"Hamer","year":"2008","journal-title":"Theriogenology"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib34","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/sj.ejhg.5201049","article-title":"Linear increase of structural and numerical chromosome 9 abnormalities in human sperm regarding age","volume":"11","author":"Bosch","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000086892","article-title":"Effect of paternal age on the frequency of cytogenetic abnormalities in human spermatozoa","volume":"111","author":"Buwe","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib36","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1016\/j.febslet.2006.03.081","article-title":"The spindle assembly checkpoint: preventing chromosome mis-segregation during mitosis and meiosis","volume":"580","author":"Malmanche","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrg2505","article-title":"The consequences of asynapsis for mammalian meiosis","volume":"10","author":"Burgoyne","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000015585","article-title":"An analysis of meiotic impairment and of sex chromosome associations throughout meiosis in XYY mice","volume":"89","author":"Mahadevaiah","year":"2000","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib39","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nrg2723","article-title":"Genetics of mammalian meiosis: regulation, dynamics and impact on fertility","volume":"11","author":"Handel","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fertnstert.2007.11.002","article-title":"Intra-individual and inter-individual variations in sperm aneuploidy frequencies in normal men","volume":"91","author":"Tempest","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib41","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1086\/302058","article-title":"Chromosome 21 disomy in the spermatozoa of the fathers of children with trisomy 21, in a population with a high prevalence of Down syndrome: increased incidence in cases of paternal origin","volume":"63","author":"Blanco","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s004390050964","article-title":"Analysis of sex chromosome aneuploidy in sperm from fathers of Turner syndrome patients","volume":"104","author":"Mart\u00ednez-Pasarell","year":"1999","journal-title":"Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib43","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/humrep\/dei321","article-title":"Sperm aneuploidy in fathers of Klinefelter's syndrome offspring assessed by multicolour fluorescent in situ hybridization using probes for chromosomes 6, 13, 18, 21, 22, X and Y","volume":"21","author":"Arnedo","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib44","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/humrep\/del279","article-title":"Histological evaluation of the human testis\u2014approaches to optimizing the clinical value of the assessment: mini review","volume":"22","author":"McLachlan","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/molehr\/gal007","article-title":"Crossover frequency and synaptonemal complex length: their variability and effects on human male meiosis","volume":"12","author":"Codina-Pascual","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib46","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.ejhg.5201956","article-title":"Is the prevalence of Klinefelter syndrome increasing?","volume":"16","author":"Morris","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib47","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1042\/BST0340574","article-title":"Meiosis in mammals: recombination, non-disjunction and the environment","volume":"34","author":"Hunt","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.envres.2006.12.001","article-title":"Gender effects on the incidence of aneuploidy in mammalian germ cells","volume":"104","author":"Pacchierotti","year":"2007","journal-title":"Environ Res"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib49","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/bmj.305.6854.609","article-title":"Evidence for decreasing quality of semen during past 50 years","volume":"305","author":"Carlsen","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/humrep\/dep390","article-title":"What has happened to human fertility?","volume":"25","author":"Joffe","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.06.042_bib51","first-page":"144","article-title":"Is there a problem with male reproduction?","volume":"5","author":"Joensen","year":"2009","journal-title":"Nat Clin Pract Endocrinol Metab"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210009957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210009957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:11:05Z","timestamp":1762150265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028210009957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0015028210009957"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.06.042","relation":{},"ISSN":["0015-0282"],"issn-type":[{"type":"print","value":"0015-0282"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meiotic chromosome abnormalities in fertile men: are they increasing?","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.06.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}