{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:16:27Z","timestamp":1790396187963,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.fertnstert.2010.09.059","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T08:01:19Z","timestamp":1289289679000},"page":"767-772.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study"],"prefix":"10.1016","volume":"95","clinical-trial-number":[{"clinical-trial-number":"nct00290251","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Lynnette K.","family":"Nieman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Blocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonja","family":"Nansel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Blithe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2010.09.059_bib1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1089\/jwh.2005.14.692","article-title":"The economic impact of uterine fibroids in the United States: a summary of published estimates","volume":"14","author":"Mauskopf","year":"2005","journal-title":"J Women\u2019s Health (2002)"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1089\/jwh.2006.15.818","article-title":"Uterine fibroids: a review of health-related quality of life assessment","volume":"15","author":"Williams","year":"2006","journal-title":"J Women\u2019s Health (2002)"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2214\/AJR.04.1767","article-title":"Mid- and long-term quality-of-life assessment in patients undergoing uterine fibroid embolization","volume":"186","author":"Bucek","year":"2006","journal-title":"AJR"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/01.AOG.0000234651.41000.58","article-title":"Annual costs associated with diagnosis of uterine leiomyomata","volume":"108","author":"Hartmann","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib5","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1097\/JOM.0b013e3181895e10","article-title":"Impaired work performance among women with symptomatic uterine fibroids","volume":"50","author":"Lerner","year":"2008","journal-title":"J Occup Environ Med\/Am Col Occup Environ Med"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jsbmb.2003.12.004","article-title":"In vitro antiprogestational\/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone","volume":"88","author":"Attardi","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib7","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/AOG.0b013e3181705d0e","article-title":"CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial","volume":"111","author":"Levens","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib8","doi-asserted-by":"crossref","unstructured":"Bulletin AT. Uterine leiomyomata. Number 192\u2014May 1994. ACOG technical bulletin. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics 1994;46:73\u201382.","DOI":"10.1016\/0020-7292(94)90317-4"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0895-4356(98)00081-X","article-title":"Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) project","volume":"51","author":"Ware","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib10","first-page":"290","article-title":"The UFS-QOL, a new disease-specific symptom and health-related quality of life questionnaire for leiomyomata","volume":"99","author":"Spies","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0015-0282(16)30062-0","article-title":"Dating the endometrial biopsy","volume":"1","author":"Noyes","year":"1950","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib12","series-title":"How to score version two of the SF-36 Health Survey","author":"Ware","year":"2000"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/modpathol.2008.19","article-title":"The spectrum of endometrial pathology induced by progesterone receptor modulators","volume":"21","author":"Mutter","year":"2008","journal-title":"Mod Pathol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib14","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/cncr.23808","article-title":"Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies","volume":"113","author":"Lacey","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0015-0282(16)59788-X","article-title":"Treatment of uterine fibroids with agonist analogs of gonadotropin-releasing hormone","volume":"49","author":"Kessel","year":"1988","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0015-0282(00)01676-9","article-title":"Effectiveness of short-term administration of tibolone plus gonadotropin-releasing hormone analogue on the surgical outcome of laparoscopic myomectomy","volume":"75","author":"Palomba","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0378-5122(89)90209-0","article-title":"Effects of gonadotrophin-releasing hormone agonist on uterine fibroids and bone density","volume":"11","author":"Bianchi","year":"1989","journal-title":"Maturitas"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0002-9378(11)91627-5","article-title":"Delayed endometrial maturation induced by daily administration of the antiprogestin RU 486: a potential new contraceptive strategy","volume":"167","author":"Batista","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib19","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1210\/jc.2006-2816","article-title":"Effects of the progesterone receptor modulator VA2914 in a continuous low dose on the hypothalamic-pituitary-ovarian axis and endometrium in normal women: a prospective, randomized, placebo-controlled trial","volume":"92","author":"Chabbert-Buffet","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejogrb.2009.06.004","article-title":"Open-label study of ultra low-dose mifepristone for the treatment of uterine leiomyomata","volume":"146","author":"Eisinger","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib21","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/humrep\/dep100","article-title":"Mifepristone for treatment of uterine leiomyoma. A prospective randomized placebo controlled trial","volume":"24","author":"Engman","year":"2009","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1479-828X.2008.00931.x","article-title":"Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial","volume":"49","author":"Bagaria","year":"2009","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib23","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1097\/AOG.0b013e31818aa930","article-title":"Mifepristone for the treatment of uterine leiomyomas: a randomized controlled trial","volume":"112","author":"Carbonell Esteve","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib24","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/01.AOG.0000243776.23391.7b","article-title":"Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trial","volume":"108","author":"Fiscella","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jmig.2005.01.022","article-title":"Twelve-month safety and efficacy of low-dose mifepristone for uterine myomas","volume":"12","author":"Eisinger","year":"2005","journal-title":"J Min Invas Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0015-0282(16)57678-X","article-title":"Regression of uterine leiomyomata to the antiprogesterone RU486: dose-response effect","volume":"64","author":"Murphy","year":"1995","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib27","first-page":"490","article-title":"[A clinical control study on the treatment of uterine leiomyoma with gonadotrophin releasing hormone agonist or mifepristone]","volume":"33","author":"Zeng","year":"1998","journal-title":"Zhonghua fu chan ke za zhi"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1067\/mob.2002.121725","article-title":"Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas","volume":"186","author":"Dueholm","year":"2002","journal-title":"Am J Obst Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/AOG.0b013e3181864943","article-title":"CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial","volume":"112","author":"Fiscella","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib30","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1210\/jc.2008-2327","article-title":"High aromatase expression in uterine leiomyoma tissues of African-American women","volume":"94","author":"Ishikawa","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bpobgyn.2008.01.014","article-title":"Molecular genetics and racial disparities of uterine leiomyomas","volume":"22","author":"Othman","year":"2008","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2010.09.059_bib32","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.steroids.2003.08.007","article-title":"Progesterone antagonists and progesterone receptor modulators: an overview","volume":"68","author":"Spitz","year":"2003","journal-title":"Steroids"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210026713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210026713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:45:34Z","timestamp":1758008734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028210026713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0015028210026713"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.09.059","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717966517.793507556","asserted-by":"object"}]},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.09.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}