{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:47:11Z","timestamp":1791172031065,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":4074,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001771","name":"Tuberous Sclerosis Alliance","doi-asserted-by":"publisher","award":["60-28050-RT732663"],"award-info":[{"award-number":["60-28050-RT732663"]}],"id":[{"id":"10.13039\/100001771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["30871011"],"award-info":[{"award-number":["30871011"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30772568"],"award-info":[{"award-number":["30772568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003179","name":"Alberta Heritage Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.fertnstert.2010.11.028","type":"journal-article","created":{"date-parts":[[2010,12,11]],"date-time":"2010-12-11T04:10:09Z","timestamp":1292040609000},"page":"1805-1808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased expression of tuberin in human uterine leiomyoma"],"prefix":"10.1016","volume":"95","author":[{"given":"Lihua","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuebing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang D.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Long","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2010.11.028_bib1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/GRF.0b013e3181b0bdcd","article-title":"Myomectomy","volume":"52","author":"Luciano","year":"2009","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1056\/NEJMe020109","article-title":"Hysterectomy\u2014still a useful operation","volume":"347","author":"Schaffer","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib3","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","article-title":"European Chromosome 16 Tuberous Sclerosis Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16","volume":"75","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/gcc.10281","article-title":"Uterine leiomyoma in the Eker rat: a unique model for important diseases of women","volume":"38","author":"Walker","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib5","first-page":"1556","article-title":"Rodent model of reproductive tract leiomyomata. Clinical and pathological features","volume":"146","author":"Everitt","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/1933719106298401","article-title":"Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in eker rats","volume":"14","author":"Cook","year":"2007","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tibs.2003.11.007","article-title":"TSC2: filling the GAP in the mTOR signaling pathway","volume":"29","author":"Li","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1469-1809.2003.00012.x","article-title":"Tuberous sclerosis: from tubers to mTOR","volume":"67","author":"Kwiatkowski","year":"2003","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib9","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1158\/0008-5472.CAN-08-4471","article-title":"Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway","volume":"69","author":"Crabtree","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/019262339802600113","article-title":"Molecular genetics of renal carcinogenesis","volume":"26","author":"Walker","year":"1998","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib11","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jcp.22230","article-title":"MicroRNA-1 inhibits myocardin-induced contractility of human vascular smooth muscle cells","volume":"225","author":"Jiang","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib12","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib13","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1002\/j.1460-2075.1995.tb00212.x","article-title":"The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain","volume":"14","author":"Pearson","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib14","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1073\/pnas.93.9.4076","article-title":"4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase","volume":"93","author":"von Manteuffel","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib15","doi-asserted-by":"crossref","first-page":"C507","DOI":"10.1152\/ajpcell.00201.2003","article-title":"The mTOR\/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation","volume":"286","author":"Martin","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1165\/rcmb.2003-0272OC","article-title":"Phophatidylinositol-3 kinase\/mammalian target of rapamycin\/p70S6K regulates contractile protein accumulation in airway myocyte differentiation","volume":"31","author":"Halayko","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib17","doi-asserted-by":"crossref","first-page":"36112","DOI":"10.1074\/jbc.M703914200","article-title":"Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1\/phosphatidylinositol 3-kinase\/Akt2 feedback signaling","volume":"282","author":"Martin","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/ATVBAHA.108.179457","article-title":"mTOR regulates vascular smooth muscle cell differentiation from human bone marrow\u2013derived mesenchymal progenitors","volume":"29","author":"Hegner","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/modpathol.3800283","article-title":"Expression profile of tuberin and some potential tumorigenic factors in 60 patients with uterine leiomyomata","volume":"18","author":"Wei","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/humrep\/dei309","article-title":"Ethnic differences in expression of the dysregulated proteins in uterine leiomyomata","volume":"21","author":"Wei","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.fertnstert.2005.01.142","article-title":"Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomata","volume":"84","author":"Wei","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib22","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm1560","article-title":"The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas","volume":"13","author":"Hernando","year":"2007","journal-title":"Nature Medicine"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jsbmb.2003.09.007","article-title":"Differential expression of Akt\/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium","volume":"87","author":"Kovacs","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib24","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1016\/j.fertnstert.2009.03.100","article-title":"Changes related to phosphatidylinositol 3-kinase\/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology","volume":"93","author":"Karra","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2119\/2007-00101.YU","article-title":"Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas","volume":"14","author":"Yu","year":"2008","journal-title":"Mol Med"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.fertnstert.2007.11.015","article-title":"Combined differential gene expression profile and pathway enrichment analyses to elucidate the molecular mechanisms of uterine leiomyoma after gonadotropin-releasing hormone treatment","volume":"90","author":"Chen","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib27","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1210\/jc.2004-0161","volume":"89","author":"Ding","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tcm.2005.11.003","article-title":"Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells","volume":"16","author":"Millette","year":"2006","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.fertnstert.2010.11.028_bib29","doi-asserted-by":"crossref","first-page":"53017","DOI":"10.1074\/jbc.M309640200","article-title":"Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway","volume":"278","author":"Gui","year":"2003","journal-title":"J Biol Chem"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210028141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028210028141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:09:25Z","timestamp":1762150165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028210028141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0015028210028141"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.11.028","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased expression of tuberin in human uterine leiomyoma","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2010.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}