{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:23:41Z","timestamp":1771464221522,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":3983,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.fertnstert.2011.04.075","type":"journal-article","created":{"date-parts":[[2011,5,21]],"date-time":"2011-05-21T22:58:23Z","timestamp":1306018703000},"page":"208-213.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Responsiveness to metformin in girls with androgen excess: collective influence of genetic polymorphisms"],"prefix":"10.1016","volume":"96","clinical-trial-number":[{"clinical-trial-number":"isrctn84749320","registry":"10.18810\/isrctn"}],"author":[{"given":"Marta","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abel","family":"L\u00f3pez-Bermejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"S\u00e1nchez-Infantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Bassols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"de Zegher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2011.04.075_bib1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ijo.2008.61","article-title":"Polycystic ovary syndrome in adolescents","volume":"32","author":"Franks","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib2","first-page":"1599","article-title":"Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism","volume":"76","author":"Iba\u00f1ez","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib3","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1210\/jcem.83.10.5205","article-title":"Precocious pubarche, hyperinsulinism and ovarian hyperandrogenism in girls: relation to reduced fetal growth","volume":"83","author":"Ib\u00e1\u00f1ez","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib4","first-page":"3526","article-title":"Sensitization to insulin in adolescent girls to normalize hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia and hyperinsulinism after precocious pubarche","volume":"85","author":"Ib\u00e1\u00f1ez","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpeds.2003.08.015","article-title":"Insulin sensitization early post-menarche prevents progression from precocious pubarche to polycystic ovary syndrome","volume":"144","author":"Ib\u00e1\u00f1ez","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib6","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1210\/jc.2008-0013","article-title":"Metformin treatment for 4 yr to reduce total and visceral fat in low-birthweight girls with precocious pubarche","volume":"93","author":"Ib\u00e1\u00f1ez","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1530\/EJE-09-0733","article-title":"Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome","volume":"162","author":"Diamanti-Kandarakis","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1124\/jpet.102.034140","article-title":"Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin","volume":"302","author":"Wang","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10038-006-0087-0","article-title":"Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin","volume":"52","author":"Shikata","year":"2007","journal-title":"J Hum Genet"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib10","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.2337\/db10-0543","article-title":"Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program","volume":"59","author":"Jablonski","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib11","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1172\/JCI40671","article-title":"Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1\/AMPK pathway via a decrease in hepatic energy state","volume":"120","author":"Foretz","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib12","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib13","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1120781","article-title":"The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin","volume":"310","author":"Shaw","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib14","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/dc09-1750","article-title":"A single nucleotide polymorphism in STK11 influences insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess","volume":"33","author":"L\u00f3pez-Bermejo","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib15","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1210\/jc.2003-030197","article-title":"Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels","volume":"88","author":"Xita","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib16","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1210\/jc.2002-021791","article-title":"Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism","volume":"88","author":"Ib\u00e1\u00f1ez","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/humrep\/dem382","article-title":"The role of sex hormone\u2013binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome","volume":"23","author":"Xita","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib18","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1016\/j.fertnstert.2010.06.083","article-title":"Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone-binding globulin and androgen receptor polymorphisms","volume":"94","author":"D\u00edaz","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib19","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00125-008-1028-6","article-title":"Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome","volume":"51","author":"Barber","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2350-11-12","article-title":"Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)","volume":"11","author":"Tan","year":"2010","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib21","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMoa0803839","article-title":"An obesity-associated FTO gene variant and increased energy intake in children","volume":"359","author":"Cecil","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib22","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1007\/s00125-008-1158-x","article-title":"Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program","volume":"51","author":"Franks","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1530\/EJE-07-0261","article-title":"Flutamide-metformin for young post-menarcheal girls with preclinical androgen excess: evidence for differential response by androgen receptor genotype","volume":"157","author":"Ong","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.metabol.2009.08.023","article-title":"Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome","volume":"59","author":"Wehr","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2008-0030","article-title":"Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review","volume":"30","author":"Palomba","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib26","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1210\/jc.2007-0441","article-title":"Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome","volume":"92","author":"Palomba","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib27","doi-asserted-by":"crossref","first-page":"E204","DOI":"10.1210\/jc.2010-0145","article-title":"Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome","volume":"95","author":"Gambineri","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2337\/db10-0805","article-title":"OCT1 expression in adipocytes could contribute to increased metformin action in obese subjects","volume":"60","author":"Moreno-Navarrete","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib29","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1210\/jc.2007-1736","article-title":"Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene","volume":"93","author":"Legro","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.04.075_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2350-9-85","article-title":"\u201cFat mass and obesity associated\u201d gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents","volume":"9","author":"M\u00fcller","year":"2008","journal-title":"BMC Med Genet"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028211006881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028211006881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:51:35Z","timestamp":1758009095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028211006881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0015028211006881"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2011.04.075","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Responsiveness to metformin in girls with androgen excess: collective influence of genetic polymorphisms","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2011.04.075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}