{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:50:07Z","timestamp":1761663007317,"version":"3.44.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.fertnstert.2011.06.074","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T14:24:26Z","timestamp":1314714266000},"page":"649-653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase"],"prefix":"10.1016","volume":"96","author":[{"given":"Feng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ling","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Zhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2011.06.074_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1749-6632.1991.tb37864.x","article-title":"Preparation of the human endometrium for implantation","volume":"622","author":"Navot","year":"1991","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1600-0897.1995.tb01136.x","article-title":"Systemic CD 56+ cells can predict pregnancy outcome","volume":"33","author":"Coulam","year":"1995","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib3","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/oxfordjournals.humrep.a137982","article-title":"Expression of perforin, granzyme A and TIA-1 by human uterine CD56+ NK cells implies they are activated and capable of effector functions","volume":"8","author":"King","year":"1983","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/369031a0","article-title":"Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice","volume":"369","author":"Kagi","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1471-4906(02)02243-3","article-title":"Assembly of the immunological synapse for T cells and NK cells","volume":"23","author":"Davis","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jri.2007.03.010","article-title":"Post-ovulatory rise of endometrial CD16\u2212 natural killer cells: in situ proliferation of residual cells or selective recruitment from circulating peripheral blood?","volume":"76","author":"Kitaya","year":"2007","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1600-0897.2006.00377.x","article-title":"Uterine (CD56+) natural killer cells recruitment: association with decidual reaction rather than embryo implantation","volume":"55","author":"Ordi","year":"2006","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib8","doi-asserted-by":"crossref","first-page":"8522","DOI":"10.4049\/jimmunol.177.12.8522","article-title":"Decidual NK cells alter in\u00a0vitro first trimester extravillous cytotrophoblast migration: a role for IFN-\u03b3","volume":"177","author":"Hu","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0015-0282(97)00189-1","article-title":"Mifepristone (RU486): a review","volume":"68","author":"Mahajan","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib10","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0039-128X(03)00131-4","article-title":"Effects of mifepristone on endometrial receptivity","volume":"68","author":"Danielsson","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-0897.2008.00664.x","article-title":"Mifepristone as an anti-implantation contraceptive drug: roles in regulation of uterine natural killer cells during implantation phase","volume":"61","author":"Zhu","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0015-0282(16)30062-0","article-title":"Dating the endometrial biopsy","volume":"1","author":"Noyes","year":"1950","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib13","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/0002-9378(92)91774-5","article-title":"A human endometrial explant system: validation and potential applications","volume":"167","author":"Dudley","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000010279","article-title":"Endometrial response to sexual steroids as assessed by prostaglandin F(2alpha) output in explant culture and hormone receptor expression","volume":"50","author":"Illouz","year":"2000","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/frne.1998.0167","article-title":"Regulation of the human menstrual cycle","volume":"19","author":"Chabbert","year":"1998","journal-title":"Front Neuroendocrinol"},{"year":"2000","series-title":"Cytotoxicity and viability assays in animal cell culture: a practical approach","author":"Wilson","key":"10.1016\/j.fertnstert.2011.06.074_bib16"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0022-1759(93)90012-V","article-title":"A new approach for measurement of cytotoxicity using colorimetric assay","volume":"160","author":"Hussain","year":"1993","journal-title":"J Immunol Method"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00005373-199907000-00027","article-title":"In vitro elution of antibiotic from antibiotic-impregnated biodegradable calcium alginate wound dressing","volume":"47","author":"Lin","year":"1999","journal-title":"J Trauma"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib19","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.fertnstert.2003.04.001","article-title":"Fluctuation of 6Ckine expression in human endometrium during the menstrual cycle","volume":"80","author":"Nakayama","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0039-128X(00)00191-4","article-title":"Role of progesterone on peri-implantation stage endometrium\u2013embryo interaction in the primate","volume":"65","author":"Sengupta","year":"2000","journal-title":"Steroids"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/oxfordjournals.humrep.a138094","article-title":"Anti-nidatory effect of a single post-ovulatory administration of mifepristone (RU486) in the rhesus monkey","volume":"8","author":"Ghosh","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib22","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/humrep\/13.4.793","article-title":"Effects of long-term low-dose mifepristone on reproductive function in women","volume":"13","author":"Croxatto","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1742-1241.2002.tb11212.x","article-title":"The potential of mifepristone (RU486) as a female contraceptive drug","volume":"56","author":"Sarkar","year":"2002","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1600-0897.1999.tb00456.x","article-title":"Natural killer cell subpopulations and cytotoxicity for infertile patients undergoing in\u00a0vitro fertilization","volume":"41","author":"Fukui","year":"1999","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib25","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1093\/humrep\/14.9.2386","article-title":"Pre-implantation endometrial leukocytes in women with recurrent miscarriage","volume":"14","author":"Quenby","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib26","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1093\/humrep\/14.11.2727","article-title":"Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study","volume":"14","author":"Clifford","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0198-8859(96)00120-6","article-title":"Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy","volume":"49","author":"Ho","year":"1996","journal-title":"Hum Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib28","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-0897.1995.tb00953.x","article-title":"Decidual natural killer cytotoxicity decreased in normal pregnancy but not in anembryonic pregnancy and recurrent spontaneous abortion","volume":"34","author":"Chao","year":"1995","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0015-0282(16)54414-8","article-title":"Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium","volume":"56","author":"Oosterlynck","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib30","first-page":"1451","article-title":"Regulation of natural-killer cell cytotoxicity and enhancement of complement factors in the spontaneously aborted mouse placenta","volume":"90","author":"Kusakabe","year":"2008","journal-title":"Supplement"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-0897.1999.tb00107.x","article-title":"Progesterone directly and indirectly affects perforin expression in cytolytic cells","volume":"42","author":"Laskarin","year":"1999","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib32","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/oxfordjournals.humrep.a019300","article-title":"Evaluation of oestrogen and progesterone receptor expression in uterine mucosal lymphocytes","volume":"11","author":"King","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/jcp.51.2.121","article-title":"Endometrial leucocytes: expression of steroid hormone receptors","volume":"51","author":"Stewart","year":"1998","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0165-2478(93)90065-A","article-title":"Enhancing effect of 17\u03b2-estradiol on human NK cell activity","volume":"36","author":"Sorachi","year":"1993","journal-title":"Immunol Lett"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib35","first-page":"1093","article-title":"Differential expression of estrogen receptors in women with systemic lupus erythematosus","volume":"33","author":"Rider","year":"2006","journal-title":"J Rheumatol"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/10799890802084614","article-title":"Estrogen receptors alpha (ESR1) and beta (ESR2) are expressed in circulating human lymphocytes","volume":"28","author":"Scariano","year":"2008","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tem.2009.06.009","article-title":"Plasma membrane estrogen receptors","volume":"20","author":"Levin","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.imlet.2010.06.003","article-title":"Estrogen receptor profiles in human peripheral blood lymphocytes","volume":"132","author":"Pierdominici","year":"2010","journal-title":"Immunol Lett"},{"key":"10.1016\/j.fertnstert.2011.06.074_bib39","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0015-0282(01)02997-1","article-title":"Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using Norplant\u2122: a pilot study","volume":"77","author":"Glasier","year":"2002","journal-title":"Fertil Steril"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028211010910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028211010910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:56:31Z","timestamp":1758009391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028211010910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0015028211010910"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2011.06.074","relation":{},"ISSN":["0015-0282"],"issn-type":[{"type":"print","value":"0015-0282"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2011.06.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}