{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:02:29Z","timestamp":1790974949060,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":3739,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.fertnstert.2011.12.011","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T19:53:36Z","timestamp":1326138816000},"page":"734-741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recombinant H2 relaxin inhibits apoptosis and induces cell proliferation in cultured leiomyoma cells without affecting those in cultured normal myometrial cells"],"prefix":"10.1016","volume":"97","author":[{"given":"Kaho","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai Y.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana S.Z.","family":"Lodhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoichi","family":"Hazama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Ebina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2011.12.011_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/er.2003-0013","article-title":"Relaxin\u2019s physiological roles and other diverse actions","volume":"25","author":"Sherwood","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0303-7207(03)00078-9","article-title":"Relaxin signaling in reproductive tissues","volume":"202","author":"Hsu","year":"2003","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0015-0282(16)54416-1","article-title":"Relaxin levels in ovum donation pregnancies","volume":"56","author":"Johnson","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib4","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1210\/jcem-47-5-1106","article-title":"Plasma immunoreactive relaxin levels in pregnant and nonpregnant women","volume":"47","author":"O\u2019Byrne","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.1065654","article-title":"Activation of orphan receptors by the hormone relaxin","volume":"295","author":"Hsu","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib6","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1095\/biolreprod63.3.697","article-title":"Collagen studies in late pregnant relaxin null mice","volume":"63","author":"Zhao","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1196\/annals.1282.056","article-title":"Clinical use of relaxin to facilitate birth: reasons for investigating the premise","volume":"1041","author":"Lee","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1471-0528.1997.tb12019.x","article-title":"Recombinant human relaxin as a cervical ripening agent","volume":"104","author":"Brennand","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib9","first-page":"328","article-title":"A randomized, double-blind, placebo-controlled trial of the safety of vaginal recombinant human relaxin for cervical ripening","volume":"82","author":"Bell","year":"1993","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.7326\/0003-4819-132-11-200006060-00004","article-title":"Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial","volume":"132","author":"Seibold","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1749-6632.2008.03803.x","article-title":"Relaxin signaling in uterine fibroids","volume":"1160","author":"Li","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.fertnstert.2008.03.043","article-title":"Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas","volume":"91","author":"Chen","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/uog.8826","article-title":"Uterine myomas during pregnancy: a longitudinal sonographic study","volume":"37","author":"De Vivo","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1477-7827-1-114","article-title":"Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates","volume":"1","author":"Ivell","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0039-128X(00)00171-9","article-title":"Effects of progesterone on uterine leiomyoma growth and apoptosis","volume":"65","author":"Maruo","year":"2000","journal-title":"Steroids"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib16","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1210\/en.2009-1327","article-title":"The effect of relaxin on cell proliferation in mouse cervix requires estrogen receptor {alpha} binding to estrogen response elements in stromal cells","volume":"151","author":"Yao","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib17","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1158\/1078-0432.CCR-06-2492","article-title":"Relaxin promotes prostate cancer progression","volume":"13","author":"Feng","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib18","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/pros.21148","article-title":"Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer","volume":"70","author":"Thompson","year":"2010","journal-title":"Prostate"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib19","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/bcr2136","article-title":"Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells","volume":"10","author":"Radestock","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib20","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1158\/1541-7786.MCR-09-0307","article-title":"Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts","volume":"8","author":"Radestock","year":"2010","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib21","first-page":"2192","article-title":"Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma","volume":"83","author":"Shimomura","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib22","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1096\/fj.03-1291fje","article-title":"Apoptotic adaptations from exercise training in skeletal and cardiac muscles","volume":"18","author":"Siu","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.lfs.2003.11.026","article-title":"Benzamide riboside induced mitochondrial mediated apoptosis in human lung cancer H520 cells","volume":"75","author":"Khanna","year":"2004","journal-title":"Life Sci"},{"issue":"Pt 1","key":"10.1016\/j.fertnstert.2011.12.011_bib24","first-page":"1","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/jc.2004-1569","article-title":"Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5\u2032-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells","volume":"90","author":"Xu","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib26","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1210\/en.2007-1176","article-title":"Relaxin acts on\u00a0stromal cells to promote epithelial and stromal proliferation and inhibit\u00a0apoptosis in the mouse cervix and vagina","volume":"149","author":"Yao","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/molehr\/gan051","article-title":"Relaxin signalling in primary\u00a0cultures of human myometrial cells","volume":"14","author":"Heng","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib28","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jsbmb.2006.08.006","article-title":"Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri","volume":"103","author":"Kovacs","year":"2007","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib29","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1210\/me.2002-0284","article-title":"Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3\u2032,5\u2032-monophosphate by relaxin","volume":"17","author":"Nguyen","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/jcb.10150","article-title":"Relaxin activates the MAP kinase pathway in human endometrial stromal cells","volume":"85","author":"Zhang","year":"2002","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib31","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1196\/annals.1282.045","article-title":"Pathways used by relaxin to regulate myometrial phospholipase C","volume":"1041","author":"Zhong","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2011.12.011_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/humupd\/dmh019","article-title":"Sex steroidal regulation of uterine\u00a0leiomyoma growth and apoptosis","volume":"10","author":"Maruo","year":"2004","journal-title":"Hum Reprod Update"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028211028639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028211028639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:58:15Z","timestamp":1758009495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028211028639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0015028211028639"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2011.12.011","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant H2 relaxin inhibits apoptosis and induces cell proliferation in cultured leiomyoma cells without affecting those in cultured normal myometrial cells","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2011.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}