{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:19:07Z","timestamp":1792646347561,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":3586,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003132","name":"Agentschap voor Innovatie door Wetenschap en Technologie","doi-asserted-by":"publisher","award":["IWT 070719"],"award-info":[{"award-number":["IWT 070719"]}],"id":[{"id":"10.13039\/501100003132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.fertnstert.2012.01.114","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T09:32:02Z","timestamp":1329989522000},"page":"503-507.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Developmental capacity of in\u00a0vitro\u2013matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm"],"prefix":"10.1016","volume":"98","author":[{"given":"Luis","family":"Guzman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ortega-Hrepich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas K.","family":"Albuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Verheyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Devroey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Smitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2012.01.114_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/oxfordjournals.humrep.a138029","article-title":"A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization","volume":"8","author":"MacDougall","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1055\/s-0030-1265680","article-title":"Ovarian hyperstimulation syndrome prevention strategies: in\u00a0vitro maturation","volume":"28","author":"Huang","year":"2010","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0015-0282(16)56891-5","article-title":"In\u00a0vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients","volume":"62","author":"Trounson","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib6","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1093\/oxfordjournals.humrep.a135896","article-title":"Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching","volume":"10","author":"Barnes","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib7","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1093\/humrep\/den332","article-title":"Selection of the optimal day for oocyte retrieval based on the diameter of the dominant follicle in hCG-primed in\u00a0vitro maturation cycles","volume":"23","author":"Son","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1530\/rep.0.1210051","article-title":"Maturation of human oocytes in\u00a0vitro and their developmental competence","volume":"121","author":"Trounson","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1530\/jrf.0.0450605","article-title":"Preovulatory and ovulatory mechanisms in oocyte maturation","volume":"45","author":"Thibault","year":"1975","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/jrf.0.0490069","article-title":"Reproductive function in prepubertal lambs: ovulation, embryo development and ovarian steroidogenesis","volume":"49","author":"Trounson","year":"1977","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib11","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1095\/biolreprod.104.035881","article-title":"Effects of follicle size and oocyte maturation conditions on maternal messenger RNA regulation and gene expression in rhesus monkey oocytes and embryos","volume":"72","author":"Zheng","year":"2005","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1071\/RD08201","article-title":"Effect of follicle size on mRNA expression in cumulus cells and oocytes of Bos indicus: an approach to identify marker genes for developmental competence","volume":"21","author":"Caixeta","year":"2009","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1530\/jrf.0.0720323","article-title":"Meiotic competence in\u00a0vitro of pig oocytes isolated from early antral follicles","volume":"72","author":"Motlik","year":"1984","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1095\/biolreprod56.1.238","article-title":"Maturation, fertilization, and development of marmoset monkey oocytes in\u00a0vitro","volume":"56","author":"Gilchrist","year":"1997","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/jrf.0.1030293","article-title":"Developmental competence of goat oocytes from follicles of different size categories following maturation, fertilization and culture in\u00a0vitro","volume":"103","author":"Crozet","year":"1995","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib16","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.theriogenology.2006.03.002","article-title":"Embryo development of prepubertal goat oocytes fertilised by intracytoplasmic sperm injection (ICSI) according to oocyte diameter","volume":"66","author":"Jimenez-Macedo","year":"2006","journal-title":"Theriogenology"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0093-691X(00)00368-X","article-title":"Oocyte diameter in relation to meiotic competence and sperm penetration","volume":"54","author":"Otoi","year":"2000","journal-title":"Theriogenology"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.theriogenology.2006.09.003","article-title":"Effect of oocyte diameter on meiotic competence, embryo development, p34 (cdc2) expression and MPF activity in prepubertal goat oocytes","volume":"67","author":"Anguita","year":"2007","journal-title":"Theriogenology"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/mrd.1080420410","article-title":"Bovine oocyte diameter in relation to maturational competence and transcriptional activity","volume":"42","author":"Fair","year":"1995","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0015-0282(16)57377-4","article-title":"The relationship between size and maturation in\u00a0vitro in the unstimulated human oocyte","volume":"63","author":"Durinzi","year":"1995","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/humrep\/dem178","article-title":"Human immature oocytes grow during culture for IVM","volume":"23","author":"Cavilla","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1095\/biolreprod.110.084418","article-title":"Cumulus-oocyte complexes from small antral follicles during the early follicular phase of menstrual cycles in rhesus monkeys yield oocytes that reinitiate meiosis and fertilize in\u00a0vitro","volume":"83","author":"Peluffo","year":"2010","journal-title":"Biol Reprod"},{"issue":"13 Suppl 1","key":"10.1016\/j.fertnstert.2012.01.114_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/humrep\/13.suppl_1.76","article-title":"Intracytoplasmic sperm injection: laboratory set-up and injection procedure","author":"Joris","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib24","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1093\/humrep\/14.9.2345","article-title":"Characterization of a top quality embryo, a step toward single-embryo transfer","volume":"14","author":"van Royen","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib25","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/humrep\/deq338","article-title":"Closed blastocyst vitrification of biopsied embryos: evaluation of 100 consecutive warming cycles","volume":"26","author":"van Landuyt","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib26","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009","volume":"92","author":"Zegers-Hochschild","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0030-1268701","article-title":"The promise of in\u00a0vitro maturation in assisted reproduction and fertility preservation","volume":"29","author":"Smitz","year":"2011","journal-title":"Semin Reprod Med"},{"issue":"4 Suppl 1","key":"10.1016\/j.fertnstert.2012.01.114_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1472-6483(12)60007-8","article-title":"In-vitro maturation of oocytes from unstimulated polycystic ovaries","author":"Tan","year":"2002","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1472-6483(10)60294-5","article-title":"Comparison of in-vitro maturation cycles with and without in-vivo matured oocytes retrieved","volume":"17","author":"Son","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1472-6483(10)61101-7","article-title":"In-vitro maturation of immature oocytes for infertile women with PCOS","volume":"8","author":"Chian","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1530\/rep.0.1220587","article-title":"Benefit of FSH priming of women with PCOS to the in\u00a0vitro maturation procedure and the outcome: a randomized prospective study","volume":"122","author":"Mikkelsen","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1472-6483(10)60168-X","article-title":"Effect of different gonadotrophin priming on IVM of oocytes from women with normal ovaries: a prospective randomized study","volume":"19","author":"Fadini","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/humupd\/dmq014","article-title":"Laboratory and embryological aspects of hCG-primed in\u00a0vitro maturation cycles for patients with polycystic ovaries","volume":"16","author":"Son","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib34","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1095\/biolreprod62.3.616","article-title":"Epigenetic modifications necessary for normal development are established during oocyte growth in mice","volume":"62","author":"Bao","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/oxfordjournals.humrep.a136365","article-title":"Dynamics of follicular growth in the human: a model from preliminary results","volume":"1","author":"Gougeon","year":"1986","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib36","series-title":"An atlas of human gametes and conceptuses: an illustrated reference for assisted reproductive technology","author":"Veeck","year":"1999"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib37","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.fertnstert.2010.10.026","article-title":"Polycystic ovary syndrome and maternal obesity affect oocyte size in in\u00a0vitro fertilization\/intracytoplasmic sperm injection cycles","volume":"95","author":"Marquard","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10815-010-9527-z","article-title":"Comparison of fertilization and embryonic development in sibling in\u00a0vivo matured oocytes retrieved from different sizes follicles from in\u00a0vitro maturation cycles","volume":"28","author":"Son","year":"2011","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cryobiol.2011.09.134","article-title":"In\u00a0vitro maturation supplements affect developmental competence of bovine cumulus-oocyte complexes and embryo quality after vitrification","volume":"63","author":"Raty","year":"2011","journal-title":"Cryobiology"},{"key":"10.1016\/j.fertnstert.2012.01.114_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1071\/RD10225","article-title":"Recent insights into oocyte-follicle cell interactions provide opportunities for the development of new approaches to in\u00a0vitro maturation","volume":"23","author":"Gilchrist","year":"2011","journal-title":"Reprod Fertil Dev"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212001732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212001732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:01:13Z","timestamp":1758009673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028212001732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0015028212001732"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.01.114","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental capacity of in\u00a0vitro\u2013matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.01.114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.06.043","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}