{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:01:14Z","timestamp":1788573674485,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":318,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Wellcome Trust Career Development Fellowship","award":["WT085235\/Z\/08\/Z"],"award-info":[{"award-number":["WT085235\/Z\/08\/Z"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.fertnstert.2012.04.022","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T13:01:24Z","timestamp":1338382884000},"page":"692-701.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study"],"prefix":"10.1016","volume":"98","author":[{"given":"Kelechi E.","family":"Nnoaham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Hummelshoj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crispin","family":"Jenkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krina T.","family":"Zondervan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2012.04.022_bib1","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1093\/humrep\/dei135","article-title":"ESHRE guideline for the diagnosis and treatment of endometriosis","volume":"20","author":"Kennedy","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/oxfordjournals.humrep.a019270","article-title":"Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK","volume":"11","author":"Hadfield","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1034\/j.1600-0412.2003.00168.x","article-title":"Diagnostic delay in women with pain and endometriosis","volume":"82","author":"Husby","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib4","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.fertnstert.2006.04.054","article-title":"What's the delay? A qualitative study of women's experiences of reaching a diagnosis of endometriosis","volume":"86","author":"Ballard","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2011.05.090","article-title":"Impact of endometriosis on quality of life and work productivity: a multi-centre study across 10 countries","volume":"96","author":"Nnoaham","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/humrep\/den379","article-title":"Surgery for endometriosis-associated infertility: a pragmatic approach","volume":"24","author":"Vercellini","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib7","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/humrep\/17.5.1334","article-title":"Laparoscopic surgery is not inherently dangerous for patients presenting with benign gynaecologic pathology. Results of a meta-analysis","volume":"17","author":"Chapron","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib8","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00261-003-0043-9","article-title":"Endometriosis of the rectovaginal septum: endovaginal US and MRI findings in two cases","volume":"28","author":"Hoogeveen","year":"2003","journal-title":"Abdom Imaging"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/1933719108330568","article-title":"Priorities for endometriosis research: recommendations from an International consensus workshop","volume":"16","author":"Rogers","year":"2009","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/humupd\/dmr013","article-title":"Endometrial alterations in endometriosis: a systematic review of putative biomarkers","volume":"17","author":"May","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humupd\/dmq009","article-title":"Peripheral biomarkers of endometriosis: a systematic review","volume":"16","author":"May","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib12","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0015-0282(01)02736-4","article-title":"Validation study of nonsurgical diagnosis of endometriosis","volume":"76","author":"Eskenazi","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib13","first-page":"1","article-title":"Boosted classification trees result in minor to modest improvement in the accuracy in classifying cardiovascular outcomes compared to conventional classification trees","volume":"1","author":"Austin","year":"2011","journal-title":"Am J Cardiovasc Dis"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/humrep\/deh627","article-title":"Presurgical diagnosis of posterior deep infiltrating endometriosis based on a\u00a0standardized questionnaire","volume":"20","author":"Chapron","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib15","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1093\/humrep\/dem236","article-title":"Evaluation of a new questionnaire for the presurgical diagnosis of bladder endometriosis","volume":"22","author":"Fedele","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib16","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0895-4356(03)00207-5","article-title":"External validation is necessary in prediction research: a clinical example","volume":"56","author":"Bleeker","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/jnci\/95.1.14","article-title":"Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification","volume":"95","author":"Simon","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib18","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(03)14686-7","article-title":"Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment","volume":"362","author":"Ntzani","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/228402650900100106","article-title":"Multi-center studies of the global impact of endometriosis and the predictive value of associated symptoms","volume":"1","author":"Nnoaham","year":"2009","journal-title":"J Endometriosis"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/ard.37.4.378","article-title":"Studies with pain rating scales","volume":"37","author":"Downie","year":"1978","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MEG.0b013e328013c0fa","article-title":"Irritable bowel syndrome and the Rome III criteria: for better or for worse?","volume":"19","author":"Gwee","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib22","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1067\/mob.2001.112904","article-title":"Chronic pelvic pain in the community\u2014symptoms, investigations, and diagnoses","volume":"184","author":"Zondervan","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib23","first-page":"541","article-title":"The community prevalence of chronic pelvic pain in women and associated illness behaviour","volume":"51","author":"Zondervan","year":"2001","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0015-0282(16)48430-X","article-title":"Revised American Fertility Society classification of endometriosis: 1985","volume":"43","year":"1985","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat Med"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib26","series-title":"Applied logistic regression","author":"Hosmer","year":"2000"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib27","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jmig.2008.07.005","article-title":"Dyschezia and posterior deep infiltrating endometriosis: analysis of 360 cases","volume":"15","author":"Seracchioli","year":"2008","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ajog.2010.02.039","article-title":"Racial and ethnic disparities in benign gynecologic conditions and associated surgeries","volume":"202","author":"Jacoby","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0015-0282(98)00355-0","article-title":"The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis","volume":"70","author":"Mol","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1749-6632.1994.tb21763.x","article-title":"Deeply infiltrating endometriosis is a disease whereas mild endometriosis could be considered a non-disease","volume":"734","author":"Koninckx","year":"1994","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib31","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/oxfordjournals.humrep.a138419","article-title":"Is mild endometriosis a condition occurring intermittently in all women?","volume":"9","author":"Koninckx","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib32","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/oxfordjournals.humrep.a138422","article-title":"Is mild endometriosis a progressive disease?","volume":"9","author":"Brosens","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ng.731","article-title":"Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis","volume":"43","author":"Painter","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib34","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/humrep\/deh374","article-title":"Clinical predictive factors for endometriosis in a Portuguese infertile population","volume":"19","author":"Calhaz-Jorge","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib35","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1046\/j.1469-0705.2002.00862.x","article-title":"A systematic review of the accuracy of ultrasound in the diagnosis of endometriosis","volume":"20","author":"Moore","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/uog.8858","article-title":"Diagnostic accuracy of transvaginal ultrasound for non-invasive diagnosis of bowel endometriosis: systematic review and meta-analysis","volume":"37","author":"Hudelist","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib37","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/humrep\/deq141","article-title":"Non-invasive diagnosis of endometriosis: the goal or own goal?","volume":"25","author":"Somigliana","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.04.022_bib38","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/archinte.168.21.2304","article-title":"Assessing new biomarkers and predictive models for use in clinical practice: a clinician's guide","volume":"168","author":"McGeechan","year":"2008","journal-title":"Arch Intern Med"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212004542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212004542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:00:41Z","timestamp":1758009641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028212004542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0015028212004542"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.04.022","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.05.028","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Reproductive Medicine. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}