{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:33:18Z","timestamp":1783783998018,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":3525,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.fertnstert.2012.06.011","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T12:51:27Z","timestamp":1341492687000},"page":"905-910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy"],"prefix":"10.1016","volume":"98","author":[{"given":"Anne","family":"Eskild","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fedorcsak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"M\u2298rkrid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom G.","family":"Tanbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2012.06.011_bib1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/oxfordjournals.humrep.a136808","article-title":"Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes","volume":"3","author":"Bonduelle","year":"1988","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198807283190401","article-title":"Incidence of early loss of pregnancy","volume":"319","author":"Wilcox","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1472-6483(10)61717-8","article-title":"Embryo-maternal signalling: how the embryo starts talking to its mother to accomplish implantation","volume":"6","author":"Herrler","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mce.2006.09.016","article-title":"Is human chorionic gonadotropin directly involved in the regulation of human implantation?","volume":"269","author":"Licht","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib5","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.fertnstert.2011.09.044","article-title":"Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates\u00a0in in\u00a0vitro fertilization\/intracytoplasmic sperm injection: a prospective randomized study","volume":"96","author":"Mansour","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1477-7827-8-102","article-title":"Biological functions of hCG and hCG-related molecules","volume":"8","author":"Cole","year":"2010","journal-title":"Reprod Biolo Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jri.2009.11.008","article-title":"Human chorionic gonadotropin: a hormone with immunological and angiogenic properties","volume":"85","author":"Tsampalasa","year":"2010","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib8","doi-asserted-by":"crossref","first-page":"349.e1","DOI":"10.1016\/j.ajog.2010.11.036","article-title":"Individual deviations in human chorionic gonadotropin concentrations during pregnancy","volume":"204","author":"Cole","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib9","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1093\/humrep\/14.6.1642","article-title":"Human chorionic gonadotrophin concentrations in early pregnancy after in-vitro fertilization","volume":"14","author":"Bjercke","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib10","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1210\/endo.133.6.8243330","article-title":"Novel self-regulation of human chorionic gonadotropin biosynthesis in term pregnancy human placenta","volume":"133","author":"Licht","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib11","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1210\/en.2005-0406","volume":"146","author":"Lappas","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib12","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.fertnstert.2009.03.079","article-title":"Adipose tissue and reproduction in women","volume":"94","author":"Bohler","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib13","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1210\/jc.2003-032127","article-title":"The leptin system during human endometrial receptivity and preimplantation development","volume":"89","author":"Cervero","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib14","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1126\/science.281.5383.1683","article-title":"Biological action of leptin as an angiogenic factor","volume":"281","author":"Sierra-Honigmann","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib15","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2527\/2004.823925x","article-title":"Adipose tissue angiogenesis","volume":"82","author":"Hausman","year":"2004","journal-title":"J Anim Sci"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib16","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1161\/ATVBAHA.107.143081","article-title":"Vascular endothelial growth factor is induced by the inflammatory cytokines interleukin-6 and oncostatin in human adipose tissue in\u00a0vitro and in murine adipose tissue in\u00a0vivo","volume":"27","author":"Rega","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib17","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.fertnstert.2012.01.112","article-title":"In\u00a0vitro fertilization is a successful treatment in endometriosis-associated infertility","volume":"97","author":"Op\u2298ien","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1034\/j.1600-0412.2000.079001043.x","article-title":"Obesity is a risk factor for early pregnancy loss after IVF or ICSI","volume":"79","author":"Fedorcs\u00e1k","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib19","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.fertnstert.2007.07.1290","article-title":"Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence","volume":"90","author":"Metwally","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3109\/09513590009167691","article-title":"Human chorionic gonadotropin levels in successful implantations after assisted reproduction techniques","volume":"14","author":"Ertzeid","year":"2000","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib21","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0015-0282(16)60906-8","article-title":"Disappearance of exogenously administered human chorionic gonadotropin","volume":"52","author":"Damewood","year":"1989","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib22","first-page":"111","article-title":"A review of body water status and the effects of age and body fatness in children and adults","volume":"11","author":"Chumlea","year":"2007","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0303-7207(87)90043-8","article-title":"Distribution of follitropin and deglycosylated follitropin in the rat- a quantitative and autoradiographic study","volume":"52","author":"Sebok","year":"1987","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000276546","article-title":"Absorption, distribution, metabolism and excretion of corifollitropin alfa, a recombinant hormone with a sustained follicle-stimulating activity","volume":"85","author":"van Schanke","year":"2010","journal-title":"Pharmacology"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib25","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/j.fertnstert.2009.08.026","article-title":"A prospective, randomized, controlled study to compare two doses of recombinant human chorionic gonadotropin in serum and follicular fluid in woman with high body mass index","volume":"93","author":"Kahraman","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib26","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0092-8674(91)90287-9","article-title":"A hepatic reticuloendothelial cell receptor specific for SO4-4GalNAc beta 1,4GlcNAc beta 1,2Man alpha that mediates rapid clearance of lutropin","volume":"67","author":"Fiete","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mce.2006.11.015","article-title":"The gonadotropins: tissue-specific angiogenic factors?","volume":"269","author":"Reisinger","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1677\/JOE-06-0101","article-title":"In\u00a0vitro effects of chorionic gonadotropin hormone on human adipose development","volume":"194","author":"Dos Santos","year":"2007","journal-title":"J Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/en.2008-0522","article-title":"Up-regulation of placental leptin by human chorionic gonadotropin","volume":"150","author":"Maym\u00f3","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib30","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/molehr\/5.11.1077","article-title":"Leptin increased secretion of hCG from cultured human cytotrophoblastic cells","volume":"5","author":"Chardonnens","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0301-2115(03)00185-4","article-title":"Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG)","volume":"110","author":"Islami","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1095\/biolreprod.102.006122","article-title":"Leptin added to primary cultures of human term placental trophoblast cells stimulated hCG secretion","volume":"68","author":"Cameo","year":"2003","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib33","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1210\/en.2009-0058","article-title":"Adiponectin attenuation of endocrine function within human term trophoblast cells","volume":"150","author":"McDonald","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib34","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1096\/fj.06-5885fje","article-title":"Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium","volume":"20","author":"Berndt","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib35","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1210\/jc.2009-0443","article-title":"Chorionic gonadotropin stimulation of angiogenesis and pericyte recruitment","volume":"94","author":"Berndt","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl A","key":"10.1016\/j.fertnstert.2012.06.011_bib36","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/j.placenta.2007.02.002","article-title":"HCG in the regulation of placental angiogenesis. Results of an in\u00a0vitro study","volume":"21","author":"Herr","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.fertnstert.2012.06.011_bib37","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1136\/bmj.314.7098.1864","article-title":"Prospective cohort study of factors influencing the relative weights of the placenta and the newborn infant","volume":"314","author":"Williams","year":"1997","journal-title":"BMJ"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212006462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212006462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:18:23Z","timestamp":1775233103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028212006462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0015028212006462"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.06.011","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}