{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:24:39Z","timestamp":1778502279715,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":3525,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.fertnstert.2012.06.035","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T15:15:59Z","timestamp":1342192559000},"page":"1053-1059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"title":["Comparative study of the therapeutic effects of oral contraceptive pills containing desogestrel, cyproterone acetate, and drospirenone in patients with polycystic ovary syndrome"],"prefix":"10.1016","volume":"98","clinical-trial-number":[{"clinical-trial-number":"ctri\/2010\/091\/000332","registry":"10.18810\/clinical-trial-registry-india"}],"author":[{"given":"Sudhindra Mohan","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayan","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2012.06.035_bib1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1210\/jcem-66-4-846","article-title":"Prospective studies of insulin sensitivity in normal women receiving oral contraceptive agents","volume":"66","author":"Kasdorf","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1210\/jcem-64-3-519","article-title":"Oral contraception and insulin sensitivity: in\u00a0vitro assessment in normal women and women with previous gestational diabetes","volume":"64","author":"Skouby","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib3","first-page":"64","article-title":"Insulin resistance, secretion and metabolism in users of oral contraception","volume":"74","author":"Godsland","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0015-0282(16)53212-9","article-title":"Effect of low dose oral contraceptive on gonadotrophins, androgens and sex hormone binding globulin in nonhirsute women","volume":"53","author":"Murphy","year":"1990","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib5","first-page":"995","article-title":"The evaluation and management of hirsutism","volume":"101","author":"Azziz","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/09637480601137066","article-title":"Comparison of two oral contraceptives containing either drospirenone or cyproterone in the treatment of hirsutism","volume":"23","author":"Batukan","year":"2007","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib7","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1210\/jc.2003-030328","article-title":"Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptives containing cyproterone or desogestrel","volume":"88","author":"Cagnacci","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib8","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib9","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and IGT in polycystic ovary syndrome: a prospective controlled study in 254 affected women","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib10","first-page":"995","article-title":"The evaluation and management of hirsutism","volume":"101","author":"Azziz","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib11","first-page":"497","article-title":"Polycystic ovary syndrome: a diagnostic challenge","volume":"14","author":"Lewis","year":"2003","journal-title":"Infert Reprod Med Clin N Am"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib12","series-title":"Rooks textbook of dermatology. Chapter 66.80. Vol. 4","article-title":"Disorders of hair","author":"Messenger","year":"2010"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib13","series-title":"IADVL textbook and atlas of dermatology","first-page":"689","article-title":"Acne, rosacea and perioral dermatitis","author":"Tutakne","year":"2003"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib14","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/diacare.22.10.1655","article-title":"A quantitative scale of acanthosis nigricans","volume":"22","author":"Burke","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib15","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/09513590902770115","article-title":"Hyperandrogenism in oligomenorrhoea with minimal or nil \u201cunwanted hair growth.\u201d","volume":"25","author":"Bhattacharya","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2265.1985.tb01061.x","article-title":"The treatment of hirsutism with a combination of desogestrel and ethinyl oestradiol","volume":"22","author":"Dewis","year":"1985","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.contraception.2010.02.009","article-title":"Effects of oral contraceptive containing ethinyl estradiol combined with drospirenone vs. desogestrel on clinical and biochemical parameters in patients with polycystic ovary syndrome","volume":"82","author":"Kriplani","year":"2010","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib18","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0015-0282(00)00718-4","article-title":"Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity","volume":"74","author":"Escobar-Morreale","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1447-0756.2011.01682.x","article-title":"Effects of ethinyl estradiol and desogestrel on clinical and metabolic parameters in Indian patients with polycystic ovary syndrome","volume":"38","author":"Bhattacharya","year":"2012","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1783\/1471189041261636","article-title":"An observational study of Yasmin in the management of women with polycystic ovary syndrome","volume":"30","author":"Palep-Sing","year":"2004","journal-title":"J Fam Plann Reprod Health Care"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib21","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1210\/jc.2003-031158","article-title":"Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study","volume":"89","author":"Guido","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0010-7824(02)00537-1","article-title":"A randomized study over 13 cycles to assess the influence of oral contraceptives containing ethinyl oestradiol combined with drospirenone or desogestrel on carbohydrate metabolism","volume":"67","author":"Gaspard","year":"2003","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.contraception.2004.12.005","article-title":"Effects of two combined oral contraceptives containing ethinyl oestradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism","volume":"71","author":"Klipping","year":"2005","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib24","first-page":"1816","article-title":"Effects of new oral contraceptive containing an antimineralocorticoid progestogen drospirenone on the rennin aldosterone system, body weight, blood pressure, glucose tolerance and lipid metabolism","volume":"80","author":"Oelkers","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/eje.0.1360339","article-title":"The clinical management of hirsutism","volume":"136","author":"Conn","year":"1997","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0010-7824(00)00133-5","article-title":"Drospirenone: pharmacology and pharmacokinetics of a unique progestogen","volume":"62","author":"Krattenmacher","year":"2000","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib27","first-page":"2559","article-title":"Medical treatment of androgen-dependent hirsutism","volume":"80","author":"Rittmaster","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1749-6632.1993.tb43875.x","article-title":"Results of an open one year study with Diane 35 in women with polycystic ovary syndrome","volume":"687","author":"Golland","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2012.06.035_bib29","first-page":"1396","article-title":"Effect of low doses of transdermal 17-beta-estradiol on carbohydrate metabolism in postmenopausal women","volume":"74","author":"Cagnacci","year":"1992","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212006887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212006887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:18:37Z","timestamp":1775233117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028212006887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0015028212006887"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.06.035","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717978515.793471100","asserted-by":"object"}]},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative study of the therapeutic effects of oral contraceptive pills containing desogestrel, cyproterone acetate, and drospirenone in patients with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.06.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}