{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:25:47Z","timestamp":1791023147116,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":3494,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1090036"],"award-info":[{"award-number":["1090036"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["20491032"],"award-info":[{"award-number":["20491032"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.fertnstert.2012.07.1060","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T07:32:34Z","timestamp":1343719954000},"page":"1283-1290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats"],"prefix":"10.1016","volume":"98","author":[{"given":"Gonzalo","family":"Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Barra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Sotomayor-Z\u00e1rate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n E.","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2012.07.1060_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-7827-4-17","article-title":"Contributions of androgen and estrogen to fetal programming of ovarian dysfunction","volume":"4","author":"Abbott","year":"2006","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.fertnstert.2008.08.067","article-title":"Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing","volume":"90","author":"Crain","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-2605.2009.01024.x","article-title":"Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators","volume":"33","author":"Padmanabhan","year":"2010","journal-title":"Int J Androl"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib4","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1210\/en.2003-0146","article-title":"Prepubertal administration of estradiol valerate disrupts cyclicity and leads to cystic ovarian morphology during adult life in the rat: role of sympathetic innervation","volume":"144","author":"Rosa","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1095\/biolreprod.107.063974","article-title":"Neonatal exposure to estradiol valerate programs ovarian sympathetic innervation and follicular development in the adult rat","volume":"78","author":"Sotomayor-Zarate","year":"2008","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1477-7827-8-99","article-title":"Unilateral sectioning of the superior ovarian nerve of rats with polycystic ovarian syndrome restores ovulation in the innervated ovary","volume":"8","author":"Morales-Ledesma","year":"2010","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib7","first-page":"38","article-title":"Programming by early nutrition in man","volume":"156","author":"Lucas","year":"1991","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib10","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/humrep\/16.8.1603","article-title":"Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: endocrine aspects","volume":"16","author":"Sir-Petermann","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib11","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/17.10.2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization","volume":"17","author":"Sir-Petermann","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11154-007-9046-0","article-title":"Polycystic ovary syndrome and its developmental origins","volume":"8","author":"Dumesic","year":"2007","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1365-2605.2005.00623.x","article-title":"Development of polycystic ovary syndrome: involvement of genetic and environmental factors","volume":"29","author":"Franks","year":"2006","journal-title":"Int J Androl"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-0031-1275519","article-title":"Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming","volume":"29","author":"Padmanabhan","year":"2011","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.maturitas.2004.09.005","article-title":"Polycystic ovary syndrome in post-menopausal women\u2014marker of the metabolic syndrome","volume":"50","author":"Margolin","year":"2005","journal-title":"Maturitas"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib16","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1093\/humrep\/deq088","article-title":"Is polycystic ovary syndrome an exception for reproductive aging?","volume":"25","author":"Tehrani","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1046\/j.1365-2265.1996.676498.x","article-title":"Polycystic ovaries in pre and post-menopausal women","volume":"44","author":"Birdsall","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib18","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1210\/endo.141.3.7395","article-title":"An increased intraovarian synthesis of nerve growth factor and its low affinity receptor is a principal component of steroid-induced polycystic ovary in the rat","volume":"141","author":"Lara","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1095\/biolreprod31.3.587","article-title":"Polycystic ovarian condition in estradiol valerate-treated rats: spontaneous changes in characteristic endocrine features","volume":"31","author":"Schulster","year":"1984","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib20","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.fertnstert.2011.09.011","article-title":"Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat","volume":"96","author":"Sotomayor-Zarate","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib21","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1095\/biolreprod.106.059303","article-title":"Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane","volume":"77","author":"Rasier","year":"2007","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2006.04.002","article-title":"Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and human data","author":"Rasier","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib23","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/humrep\/16.5.1020","article-title":"Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides","volume":"16","author":"Krstevska-Konstantinova","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpag.2010.06.003","article-title":"Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought","volume":"24","author":"Bronstein","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib25","first-page":"3148","article-title":"Isolated premature pubarche: ultrasonographic and color Doppler analysis\u2014a longitudinal study","volume":"87","author":"Battaglia","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/humrep\/del395","article-title":"Polycystic ovaries after precocious pubarche: relation to prenatal growth","volume":"22","author":"Ibanez","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1477-7827-7-64","article-title":"Increases in norepinephrine release and ovarian cyst formation during ageing in the rat","volume":"7","author":"Acuna","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0028-1108007","article-title":"Role of neurotrophic factors in early ovarian development","volume":"27","author":"Dissen","year":"2009","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib29","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0140-6736(03)14410-8","article-title":"Formation and early development of follicles in the polycystic ovary","volume":"362","author":"Webber","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1530\/REP-09-0392","article-title":"Differences in oocyte development and estradiol sensitivity among mouse strains","volume":"139","author":"Pepling","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1095\/biolreprod42.1.21","article-title":"Estrogen effects on the synaptology and neural membranes of the rat hypothalamic arcuate nucleus","volume":"42","author":"Naftolin","year":"1990","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/BF03350785","article-title":"Insights into hypothalamic-pituitary dysfunction in polycystic ovary syndrome","volume":"21","author":"Hall","year":"1998","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2002-36706","article-title":"Regulation of gonadotropin secretion: implications for polycystic ovary syndrome","volume":"20","author":"McCartney","year":"2002","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib34","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1210\/endo.133.6.8243293","article-title":"Ovarian steroidal response to gonadotropins and beta-adrenergic stimulation is enhanced in polycystic ovary syndrome: role of sympathetic innervation","volume":"133","author":"Barria","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib35","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1210\/endo.133.6.7902268","article-title":"Activation of ovarian sympathetic nerves in polycystic ovary syndrome","volume":"133","author":"Lara","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib36","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1071\/RD07075","article-title":"Sympathetic pharmacological denervation in ageing rats: effects on ovulatory response and follicular population","volume":"19","author":"Chavez-Genaro","year":"2007","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.fertnstert.2012.07.1060_bib37","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0015-0282(01)01805-2","article-title":"Increase in nerve fibers and loss of mast cells in polycystic and postmenopausal ovaries","volume":"75","author":"Heider","year":"2001","journal-title":"Fertil Steril"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212017955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028212017955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:01:26Z","timestamp":1758009686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028212017955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0015028212017955"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.07.1060","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2012.07.1060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}