{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T08:57:50Z","timestamp":1768726670177,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":2948,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.fertnstert.2014.02.005","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T20:28:35Z","timestamp":1395433715000},"page":"1337-1343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives"],"prefix":"10.1016","volume":"101","author":[{"given":"Yukiko","family":"Bono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Kiyono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunari","family":"Mizumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Maida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2014.02.005_bib1","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Clinical practice. Endometriosis","volume":"362","author":"Giudice","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib2","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib3","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.fertnstert.2007.08.051","article-title":"Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial","volume":"90","author":"Harada","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.fertnstert.2007.12.080","article-title":"Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis\u2014a randomized, double-blind, multicenter, controlled trial","volume":"91","author":"Harada","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib5","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.fertnstert.2011.02.045","article-title":"Evaluation of a low-dose oral contraceptive pill for primary dysmenorrhea: a placebo-controlled, double-blind, randomized trial","volume":"95","author":"Harada","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib6","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1447-0756.2009.01076.x","article-title":"Long-term use of dienogest for the treatment of endometriosis","volume":"35","author":"Momoeda","year":"2009","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejogrb.2013.11.030","article-title":"Norethisterone acetate versus norethisterone acetate combined with letrozole for the treatment of ovarian endometriotic cysts: a patient preference study","volume":"174","author":"Ferrero","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib8","doi-asserted-by":"crossref","first-page":"504.e1","DOI":"10.1016\/j.ajog.2007.11.010","article-title":"Postoperative oral contraceptive exposure and risk of endometrioma recurrence","volume":"198","author":"Vercellini","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.rbmo.2010.04.018","article-title":"Post-operative endometriosis recurrence: a plea for prevention based on pathogenetic, epidemiological and clinical evidence","volume":"21","author":"Vercellini","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib10","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/humrep\/dep259","article-title":"Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis","volume":"24","author":"Seracchioli","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.fertnstert.2009.03.083","article-title":"Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial","volume":"94","author":"Seracchioli","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0015-0282(02)03099-6","article-title":"Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis","volume":"77","author":"Meresman","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/humupd\/dmg030","article-title":"Progestogens for endometriosis: forward to the past","volume":"9","author":"Vercellini","year":"2003","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-0029-1242991","article-title":"Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis","volume":"28","author":"Bulun","year":"2010","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mce.2005.11.041","article-title":"Progesterone resistance in endometriosis: link to failure to metabolize estradiol","volume":"248","author":"Bulun","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.0.0250001","article-title":"Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease","volume":"25","author":"Labrie","year":"2000","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-0378(01)00132-2","article-title":"Mechanisms of excessive estrogen formation in endometriosis","volume":"55","author":"Bulun","year":"2002","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib18","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1210\/en.2007-0665","article-title":"Inflammatory status influences aromatase and steroid receptor expression in endometriosis","volume":"149","author":"Bukulmez","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib19","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1093\/humrep\/dem310","article-title":"Estrogen metabolizing enzymes in endometrium and endometriosis","volume":"22","author":"Dassen","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib20","first-page":"4474","article-title":"Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol","volume":"83","author":"Zeitoun","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib21","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/humrep\/dei462","article-title":"Endometriosis and the risk of cancer with special emphasis on ovarian cancer","volume":"21","author":"Melin","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib22","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/bjc.2012.26","article-title":"Creation of immortalised epithelial cells from ovarian endometrioma","volume":"106","author":"Bono","year":"2012","journal-title":"Br J Cancer"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.canlet.2013.04.010","article-title":"The PRB-dependent FOXO1\/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth","volume":"336","author":"Nakamura","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib24","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/S0149-2918(02)80086-8","article-title":"The pharmacokinetics of sumatriptan when administered with norethindrone 1 mg\/ethinyl estradiol 0.035 mg in healthy volunteers","volume":"24","author":"Moore","year":"2002","journal-title":"Clin Ther"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1385\/ENDO:16:3:217","article-title":"Transactivation of progestin- and estrogen-responsive promoters by 19-nor progestins in African green monkey kidney CV1 cells","volume":"16","author":"Pasapera","year":"2001","journal-title":"Endocrine"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-2001-15111","article-title":"Regulation of estrogen receptor alpha and progesterone receptor (isoform A and B) expression in cultured human endometrial cells","volume":"109","author":"Prange-Kiel","year":"2001","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.fertnstert.2014.02.005_bib27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1074\/jbc.M407879200","article-title":"Cell- and ligand-specific regulation of promoters containing activator protein-1 and Sp1 sites by estrogen receptors alpha and beta","volume":"280","author":"Schultz","year":"2005","journal-title":"J Biol Chem"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214001435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214001435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:12:17Z","timestamp":1758010337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028214001435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0015028214001435"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.02.005","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}