{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:29:18Z","timestamp":1785882558169,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":2856,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.fertnstert.2014.05.001","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T11:58:16Z","timestamp":1403611096000},"page":"424-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Efficacy and safety of intrauterine insemination and assisted reproductive technology in populations serodiscordant for human immunodeficiency virus: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-6513","authenticated-orcid":false,"given":"Arti","family":"Barnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4779-0850","authenticated-orcid":false,"given":"Daniel","family":"Riche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-6457","authenticated-orcid":false,"given":"Leandro","family":"Mena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8se","family":"Sison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8920-4496","authenticated-orcid":false,"given":"Raveena","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-646X","authenticated-orcid":false,"given":"James","family":"Shwayder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Preston","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2014.05.001_bib1","first-page":"249","article-title":"HIV-1 infection and artificial insemination with processed sperm","volume":"39","year":"1990","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib2","first-page":"515","article-title":"Donor insemination and human immunodeficiency virus transmission","volume":"91","author":"Wortley","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib3","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/0140-6736(92)92495-2","article-title":"Insemination of HIV-negative women with processed semen of HIV-positive partners","volume":"340","author":"Semprini","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/00002030-200105250-00017","article-title":"Sperm mitochondrial DNA deletions as a consequence of long term highly active antiretroviral therapy","volume":"15","author":"White","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2164\/jandrol.106.001529","article-title":"Decreased semen volume and spermatozoa motility in HIV-1-infected patients under antiretroviral treatment","volume":"28","author":"Bujan","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib6","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/humrep\/deh426","article-title":"The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing","volume":"19","author":"Nicopoullos","year":"2004","journal-title":"Hum Reprod"},{"issue":"Suppl 2","key":"10.1016\/j.fertnstert.2014.05.001_bib7","doi-asserted-by":"crossref","first-page":"ii22","DOI":"10.1136\/sti.2010.043620","article-title":"Fertility of HIV-infected women: insights from demographic and health surveys","volume":"86","author":"Chen","year":"2010","journal-title":"Sex Transm Infect"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib8","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1086\/317436","article-title":"Gynecologic infections in human immunodeficiency virus-infected women","volume":"31","author":"Sobel","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ygyno.2004.10.003","article-title":"Management and outcome of cervical intraepithelial neoplasia lesions: a study of matched cases according to HIV status","volume":"96","author":"Gilles","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1413-8670(11)70213-6","article-title":"Use of assisted reproductive technology to separate sperm from human immunodeficiency virus infected men resulting in pregnancy among serodiscordant couples","volume":"15","author":"Schuffner","year":"2011","journal-title":"Braz J Infect Dis"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib11","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1093\/humrep\/del277","article-title":"ART outcome in HIV-infected patients","volume":"21","author":"Manigart","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.aids.0000196161.25647.35","article-title":"Decreased pregnancy rate after in-vitro fertilization in HIV-infected women receiving HAART","volume":"20","author":"Coll","year":"2006","journal-title":"AIDS"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib13","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.fertnstert.2009.07.1663","article-title":"HIV-1 or hepatitis C chronic infection in serodiscordant infertile couples has no impact on infertility treatment outcome","volume":"93","author":"Prisant","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.fertnstert.2010.09.018","article-title":"HIV-positive patients undertaking ART have longer infertility histories than age-matched control subjects","volume":"95","author":"Santulli","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib15","series-title":"American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2009 Assisted reproductive technology success rates: national summary and fertility clinic reports","author":"Centers for Disease Control and Prevention","year":"2011"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib16","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1093\/humrep\/deh460","article-title":"Report of the results of a 2 year programme of sperm wash and ICSI treatment for human immunodeficiency virus and hepatitis C virus serodiscordant couples","volume":"19","author":"Garrido","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fertnstert.2007.02.004","article-title":"Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couple (SCDs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome","volume":"89","author":"Melo","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib18","first-page":"1496","article-title":"Assisted reproduction for HIV discordant couples","volume":"171","author":"Kazlauskaite","year":"2009","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/humupd\/dmp003","article-title":"Intrauterine insemination","volume":"15","author":"ESHRE Capri Workshop Group","year":"2009","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7883\/yoken.JJID.2009.173","article-title":"Studies of assisted reproduction techniques (ART) for HIV-1-discordant couples using washed sperm and the nested PCR method: a comparison of the pregnancy rates in HIV-1-discordant couples and control couples","volume":"62","author":"Kashima","year":"2009","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib21","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/humrep\/dei493","article-title":"Ovarian response to stimulation of HIV-positive patients during IVF\u00a0treatment: a matched, controlled study","volume":"21","author":"Martinet","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/humupd\/dmp012","article-title":"Approaches to improve the diagnosis and management of infertility","volume":"15","author":"Devroey","year":"2009","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0015-0282(01)03208-3","article-title":"Attitudes on access to services at assisted reproductive technology clinics: comparisons with clinic policy","volume":"77","author":"Stern","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib24","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0029-7844(03)00012-7","article-title":"Understanding the motivations, concerns, and desires of human immunodeficiency virus 1-serodiscordant couples wishing to have children through assisted reproduction","volume":"101","author":"Klein","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib25","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0140-6736(00)04331-2","article-title":"Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda","volume":"357","author":"Gray","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib26","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1097\/00002030-199710000-00008","article-title":"Effect of\u00a0antiviral treatment on the shedding of HIV-1 in semen","volume":"11","author":"Vernazza","year":"1997","journal-title":"AIDS"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00007435-200005000-00001","article-title":"Effect of coinfection with STDs and of STD treatment on HIV shedding in genital-tract secretions: systematic review and data synthesis","volume":"27","author":"Rotchford","year":"2000","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib28","doi-asserted-by":"crossref","first-page":"e1001251","DOI":"10.1371\/journal.pmed.1001251","article-title":"Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples","volume":"9","author":"Cohen","year":"2012","journal-title":"PLoS Med"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0015-0282(98)00102-2","article-title":"Human immunodeficiency virus type 1-serodiscordant couples can bear healthy children after undergoing intrauterine insemination","volume":"70","author":"Marina","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib30","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/humrep\/deg258","article-title":"Assisted reproduction techniques for HIV serodiscordant couples: 18 months of experience","volume":"18","author":"Ohl","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib31","first-page":"259","article-title":"Reproductive assistance to HIV-discordant couples\u2014the German approach","volume":"6","author":"Weigel","year":"2001","journal-title":"Eur J\u00a0Med Res"},{"issue":"Suppl 1","key":"10.1016\/j.fertnstert.2014.05.001_bib32","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/S0015-0282(02)03684-1","article-title":"Intrauterine insemination (IUI), in\u00a0vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in human immunodeficiency virus (HIV) serodiscordant couples: results and perspectives","volume":"78","author":"Quintana","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib33","first-page":"319","article-title":"Insemination from HIV-positive males","volume":"144","author":"Lowenstein","year":"2005","journal-title":"Harefuah"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib34","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1093\/humrep\/dei185","article-title":"Encouraging results despite complexity of multidisciplinary care of HIV-infected women using assisted reproduction techniques","volume":"20","author":"Ohl","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib35","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1093\/humrep\/dei119","article-title":"Outcome of ICSI in HIV-1-infected women","volume":"20","author":"Terriou","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejogrb.2007.04.011","article-title":"Good efficiency of intrauterine insemination programme for serodiscordant couples with HIV-1 infected male partner: a retrospective comparative study","volume":"135","author":"Bujan","year":"2007","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib37","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1097\/QAD.0b013e3282703879","article-title":"Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected: results from the European CREAThE network","volume":"21","author":"Bujan","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib38","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/humrep\/del422","article-title":"Safety of sperm washing and ART outcome in 741 HIV-1-serodiscordant couples","volume":"22","author":"Savasi","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1472-6483(10)60082-X","article-title":"A systematic, multidisciplinary approach to address the reproductive needs of HIV-seropositive women","volume":"19","author":"Douglas","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib40","first-page":"322","article-title":"Assisted reproductive technologies to establish pregnancies in couple with an HIV-1-infected man","volume":"67","author":"van Leeuwen","year":"2009","journal-title":"Neth J Med"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib41","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.fertnstert.2008.04.013","article-title":"Providing fertility care to men seropositive for human immunodeficiency virus: reviewing 10 years of experience and 420 consecutive cycles of in\u00a0vitro fertilization and intracytoplasmic sperm injection","volume":"91","author":"Sauer","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib42","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/humrep\/deq134","article-title":"A decade of sperm washing: clinical correlates of successful insemination outcome","volume":"25","author":"Nicopoullos","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib43","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0929-6646(11)60075-2","article-title":"Outcomes of assisted reproductive techniques for HIV-1-discordant couples using thawed washed sperm in Taiwan: comparison with control and testicular sperm extraction\/microscopic epididymal sperm aspiration groups","volume":"110","author":"Wu","year":"2011","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.fertnstert.2014.05.001_bib44","doi-asserted-by":"crossref","first-page":"402.e1","DOI":"10.1016\/j.ajog.2013.02.009","article-title":"Safe conception for HIV-discordant couples: insemination with processed semen from the HIV-infected partner","volume":"208","author":"Semprini","year":"2013","journal-title":"Am J Obstet Gynecol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214004130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214004130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:10:20Z","timestamp":1758010220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028214004130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0015028214004130"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.05.001","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of intrauterine insemination and assisted reproductive technology in populations serodiscordant for human immunodeficiency virus: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}