{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:38:05Z","timestamp":1789133885799,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":2856,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.fertnstert.2014.05.012","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T15:32:17Z","timestamp":1403710337000},"page":"589-596.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes"],"prefix":"10.1016","volume":"102","author":[{"given":"Yangang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Chiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2014.05.012_bib1","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1210\/jc.2008-0369","article-title":"Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries","volume":"93","author":"Franks","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0015-0282(00)00688-9","article-title":"Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls","volume":"74","author":"Wu","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.fertnstert.2010.07.1090","article-title":"Berberine reduces insulin resistance induced by dexamethasone in theca cells in\u00a0vitro","volume":"95","author":"Zhao","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib4","first-page":"415","article-title":"Insulin resistance and fertility in polycystic ovary syndrome","volume":"1","author":"Fica","year":"2008","journal-title":"J Med Life"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib5","first-page":"403","article-title":"Loss of PKB\u03b2\/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in\u00a0vivo","volume":"5","author":"Restuccia","year":"2012","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1080\/09513590802288242","article-title":"The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review","volume":"24","author":"Jing","year":"2008","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.steroids.2013.05.005","article-title":"Ovulation induction in women with polycystic ovary syndrome","volume":"78","author":"Perales-Puchalt","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib8","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.00667.2010","article-title":"The physiological basis of complementary and alternative medicines for polycystic ovary syndrome","volume":"301","author":"Raja-Khan","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4314\/ajtcam.v8i4.3","article-title":"Combination of acupuncture and Chinese medicinal herbs in treating model rats with polycystic ovary syndrome","volume":"8","author":"Ma","year":"2011","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib10","doi-asserted-by":"crossref","first-page":"R869","DOI":"10.1152\/ajpregu.00334.2010","article-title":"Cryptotanshinone reverses reproductive and metabolic disturbances in prenatally androgenized rats via regulation of ovarian signaling mechanisms and androgen synthesis","volume":"300","author":"Yang","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1095\/biolreprod.113.107862","article-title":"Effect of glucocorticoid-induced insulin resistance on follicle development and ovulation","volume":"88","author":"Hackbart","year":"2013","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cmet.2011.12.002","article-title":"PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue","volume":"15","author":"Matsubara","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-0031-1299765","article-title":"Differential diagnosis of hyperandrogenism in women with polycystic ovary syndrome","volume":"120","author":"Racho\u0144","year":"2012","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rvsc.2013.09.016","article-title":"Evaluation of apoptosis in long-term culture of vitrified mouse whole ovaries","volume":"96","author":"Abdi","year":"2014","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib15","first-page":"181","article-title":"Steroid production and follicular development of neonatal mouse ovary during in\u00a0vitro culture","volume":"7","author":"Abdi","year":"2013","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/toxsci\/48.2.230","article-title":"Pharmacokinetic considerations of dexamethasone-induced developmental toxicity in rats","volume":"48","author":"Hansen","year":"1999","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib17","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1124\/jpet.105.100701","article-title":"A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza","volume":"317","author":"Zhang","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"86 Suppl 1","key":"10.1016\/j.fertnstert.2014.05.012_bib18","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.fertnstert.2006.04.011","article-title":"Insulin resistance in women with polycystic ovary syndrome","author":"Dunaif","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib19","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1210\/jc.2011-0075","article-title":"Evidences for the existence of a low dopaminergic tone in polycystic ovarian syndrome: implications for OHSS development and treatment","volume":"96","author":"G\u00f3mez","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib20","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1038\/nutd.2010.3","article-title":"Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue","volume":"1","author":"Gathercole","year":"2011","journal-title":"Nutr Diabetes"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib21","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/humrep\/del053","article-title":"Clomiphene citrate and dexamethazone in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective placebo-controlled study","volume":"21","author":"Elnashar","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ptr.3513","article-title":"Effect of Salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial","volume":"26","author":"Qian","year":"2012","journal-title":"Phytother Res"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib23","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/ptr.4611","article-title":"Effect of Salvia miltiorrhiza hydrophilic extract on the endothelial biomarkers in diabetic patients with chronic artery disease","volume":"26","author":"Qian","year":"2012","journal-title":"Phytother Res"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-2187-5-1","article-title":"AMPK exerts dual regulatory effects on the PI3K pathway","volume":"5","author":"Tao","year":"2010","journal-title":"J Mol Signal"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbrc.2011.11.073","article-title":"Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway","volume":"417","author":"Jung","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib26","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.phymed.2010.05.003","article-title":"Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in\u00a0vitro","volume":"17","author":"Wang","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3109\/09513590.2012.736563","article-title":"Effects of metformin on serum insulin and anti-mullerian hormone levels and on hyperandrogenism in patients with polycystic ovary syndrome","volume":"29","author":"Nascimento","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/2042018811423770","article-title":"Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome","volume":"2","author":"Pangaribuan","year":"2011","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib29","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1210\/jcem.87.6.8568","article-title":"Additive effects of insulin-sensitizing and anti-androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation","volume":"87","author":"Ib\u00e1\u00f1ez","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/me.2004-0178","article-title":"Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome","volume":"19","author":"Nelson-Degrave","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/en.2003-0329","article-title":"Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1\/2 in human ovarian theca cells","volume":"145","author":"Munir","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib32","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/oxfordjournals.jbchem.a124459","article-title":"Dexamethasone induces the GLUT4 glucose transporter, and responses of glucose transport to norepinephrine and insulin in primary cultures of brown adipocytes","volume":"115","author":"Shimizu","year":"1994","journal-title":"J Biochem"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib33","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1463-1326.2012.01585.x","article-title":"Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes","volume":"14","author":"Hussey","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.fertnstert.2014.05.012_bib34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.reprotox.2006.08.008","article-title":"In\u00a0vitro effects of dexamethasone on mouse ovarian function and pre-implantation embryo development","volume":"23","author":"Van Merris","year":"2007","journal-title":"Reprod Toxicol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214004609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214004609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:14:00Z","timestamp":1758010440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028214004609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0015028214004609"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.05.012","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}