{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:26:27Z","timestamp":1767828387363,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":2795,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","award":["11-1553"],"award-info":[{"award-number":["11-1553"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.fertnstert.2014.06.048","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T07:45:12Z","timestamp":1407743112000},"page":"1117-1123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Is subfertility or fertility treatment associated with long-term growth in\u00a0the offspring? A cohort study"],"prefix":"10.1016","volume":"102","author":[{"given":"Bj\u00f8rn","family":"Bay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik Lykke","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik Schi\u00f8ler","family":"Kesmodel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2014.06.048_bib1","unstructured":"ESHRE. The world's number of IVF and ICSI babies has now reached a calculated total of 5 million. Available from: http:\/\/www.eshre.eu\/ESHRE\/English\/Press-Room\/Press-Releases\/Press-releases-2012\/5-million-babies\/page.aspx\/1606, 2012:Press release."},{"key":"10.1016\/j.fertnstert.2014.06.048_bib2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/humrep\/det036","article-title":"International Committee for Monitoring Assisted Reproductive Technologies (ICMART) world report: assisted reproductive technology 2004","volume":"28","author":"Sullivan","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib3","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1093\/humrep\/des255","article-title":"Assisted reproductive technology in Europe, 2008: Results generated from European registers by ESHRE","volume":"27","author":"Ferraretti","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib4","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","article-title":"Reproductive technologies and the risk of birth defects","volume":"366","author":"Davies","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/humupd\/dms062","article-title":"The longer-term health outcomes for children born as a result of IVF treatment. Part I. General health outcomes","volume":"19","author":"Hart","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.AOG.0000114989.84822.51","article-title":"Perinatal outcomes in singletons following in\u00a0vitro fertilization: a meta-analysis","volume":"103","author":"Jackson","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0140-6736(07)60456-5","article-title":"Outcome of assisted reproduction","volume":"370","author":"Sutcliffe","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/humrep\/dep456","article-title":"Effect of in\u00a0vitro culture of human embryos on birthweight of newborns","volume":"25","author":"Dumoulin","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib10","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/humrep\/des145","article-title":"Further evidence that culture media affect perinatal outcome: findings after transfer of fresh and cryopreserved embryos","volume":"27","author":"Nelissen","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib11","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1093\/humrep\/deg444","article-title":"Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort","volume":"18","author":"Basso","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib12","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0029-7844(97)00045-8","article-title":"Time to pregnancy and preterm delivery","volume":"89","author":"Henriksen","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0140-6736(08)61041-7","article-title":"Effects of technology or maternal factors on perinatal outcome after assisted fertilisation: a population-based cohort study","volume":"372","author":"Romundstad","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib14","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/cs0950115","article-title":"In utero programming of chronic disease","volume":"95","author":"Barker","year":"1998","journal-title":"Clin Sci"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/bmj.318.7181.427","article-title":"Catch-up growth in childhood and death from coronary heart disease: longitudinal study","volume":"318","author":"Eriksson","year":"1999","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib17","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/bmj.320.7240.967","article-title":"Association between postnatal catch-up growth and obesity in childhood: prospective cohort study","volume":"320","author":"Ong","year":"2000","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/1403494809357093","article-title":"Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study","volume":"38","author":"Kesmodel","year":"2010","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/14034948010290040201","article-title":"The Danish National Birth Cohort\u2014its background, structure and aim","volume":"29","author":"Olsen","year":"2001","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib20","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1471-0528.2012.03395.x","article-title":"The effect of alcohol binge drinking in early pregnancy on general intelligence in children","volume":"119","author":"Kesmodel","year":"2012","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib21","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/humrep\/dep179","article-title":"Validation of self-reported data on assisted conception in the Danish National Birth Cohort","volume":"24","author":"Hvidtjorn","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib22","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1471-0528.2012.03393.x","article-title":"The effect of different alcohol drinking patterns in early to mid pregnancy on the child's intelligence, attention, and executive function","volume":"119","author":"Kesmodel","year":"2012","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib23","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen","year":"1998","journal-title":"Dan Med Bull"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib24","series-title":"Stata Statistical Software: Release 12","year":"2011"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1472-6483(10)62116-5","article-title":"Medical follow-up study of 5-year-old ICSI children","volume":"9","author":"Bonduelle","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib26","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1093\/humrep\/den309","article-title":"Pubertal development in children and adolescents born after IVF and spontaneous conception","volume":"23","author":"Ceelen","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib27","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.fertnstert.2007.04.049","article-title":"Perinatal outcome, health, growth, and medical care utilization of 5- to 8-year-old intracytoplasmic sperm injection singletons","volume":"89","author":"Knoester","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib28","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1016\/j.fertnstert.2010.12.037","article-title":"Weight of in\u00a0vitro fertilization and intracytoplasmic sperm injection singletons in early childhood","volume":"95","author":"Woldringh","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib29","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1093\/humrep\/dep273","article-title":"Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8\u201318 years of IVF children and spontaneously conceived controls born to subfertile parents","volume":"24","author":"Ceelen","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib30","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/humrep\/deg445","article-title":"Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF","volume":"18","author":"Koivurova","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib31","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1093\/humrep\/des249","article-title":"Ovarian stimulation leads to shorter stature in childhood","volume":"27","author":"Savage","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib32","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1016\/j.fertnstert.2013.02.009","article-title":"Phenotypic differences in children conceived from fresh and thawed embryos in in\u00a0vitro fertilization compared with naturally conceived children","volume":"99","author":"Green","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.rbmo.2009.10.006","article-title":"Growth of children conceived by IVF and ICSI up to 12 years of age","volume":"20","author":"Basatemur","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib34","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/humrep\/del372","article-title":"Medical outcome of 8-year-old singleton ICSI children (born >or=32 weeks' gestation) and a spontaneously conceived comparison group","volume":"22","author":"Belva","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/humrep\/deh592","article-title":"A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in\u00a0vitro fertilization and natural conception","volume":"20","author":"Bonduelle","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib36","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1210\/jc.2006-0701","article-title":"Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction","volume":"91","author":"Kai","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib37","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.fertnstert.2003.06.004","volume":"80","author":"Place","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib38","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(97)08247-0","article-title":"Postnatal growth and health in children born after cryopreservation as embryos","volume":"351","author":"Wennerholm","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib39","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1210\/jc.2006-2465","article-title":"In\u00a0vitro fertilization improves childhood growth and metabolism","volume":"92","author":"Miles","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1542\/peds.90.3.424","article-title":"Growth and development of children conceived by in\u00a0vitro fertilization","volume":"90","author":"Brandes","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib41","doi-asserted-by":"crossref","first-page":"F355","DOI":"10.1136\/adc.2008.144402","article-title":"In\u00a0vitro fertilisation and use of ovulation enhancers may both influence childhood height in very low birthweight infants","volume":"94","author":"Makhoul","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib42","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/EDE.0b013e3181a819a1","article-title":"Overadjustment bias and unnecessary adjustment in epidemiologic studies","volume":"20","author":"Schisterman","year":"2009","journal-title":"Epidemiology"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/ije\/31.1.163","article-title":"Fallibility in estimating direct effects","volume":"31","author":"Cole","year":"2002","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib44","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.fertnstert.2009.03.008","article-title":"Ovarian hyperstimulation and the in\u00a0vitro fertilization procedure do not influence early neuromotor development; a history of subfertility does","volume":"93","author":"Middelburg","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.06.048_bib45","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/bmj.38919.495718.AE","article-title":"Infertility, infertility treatment, and\u00a0congenital malformations: Danish national birth cohort","volume":"333","author":"Zhu","year":"2006","journal-title":"Br Med J"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214005949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214005949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:12:10Z","timestamp":1758010330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028214005949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0015028214005949"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.06.048","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is subfertility or fertility treatment associated with long-term growth in\u00a0the offspring? A cohort study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}