{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:57:30Z","timestamp":1791489450709,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":2764,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.fertnstert.2014.07.1240","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T20:48:18Z","timestamp":1410382098000},"page":"1468-1476.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists"],"prefix":"10.1016","volume":"102","author":[{"given":"Hortensia","family":"Ferrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen M.","family":"Garc\u00eda-Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Gayt\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sim\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Gayt\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pellicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2014.07.1240_bib1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1056\/NEJMp038106","article-title":"The pathogenesis of the ovarian hyperstimulation syndrome","volume":"349","author":"Kaiser","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/humupd\/8.6.559","article-title":"Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review","volume":"8","author":"Delvigne","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib3","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1172\/JCI4814","article-title":"Role of vascular endothelial cell growth factor in ovarian hyperstimulation syndrome","volume":"102","author":"Levin","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0140-6736(94)93001-5","article-title":"Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome","volume":"344","author":"McClure","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib5","first-page":"1967","article-title":"Human chorionic gonadotropin\u2013dependent expression of vascular endothelial growth factor\/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome","volume":"80","author":"Neulen","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib6","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1210\/jcem.87.7.8651","article-title":"Human chorionic gonadotropin\u2013induced ovarian hyperstimulation syndrome is associated with up regulation of vascular endothelial growth factor","volume":"87","author":"Wang","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib7","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1210\/en.2002-220204","article-title":"Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats and this effect is prevented by receptor blockade","volume":"143","author":"G\u00f3mez","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib8","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1074\/jbc.M002016200","article-title":"Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants","volume":"276","author":"Gille","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1469-7580.2002.00066.x","article-title":"Regulation of microvascular permeability by vascular endothelial growth factors","volume":"200","author":"Bates","year":"2002","journal-title":"J Anat"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/humupd\/dmn008","article-title":"Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome","volume":"14","author":"Soares","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0015-0282(98)00249-0","article-title":"Serum vascular endothelial growth factor and Doppler blood flow velocities in in\u00a0vitro fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries","volume":"70","author":"Agrawal","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.fertnstert.2010.03.028","article-title":"Preventing ovarian hyperstimulation syndrome: guidance for the clinician","volume":"94","author":"Humaidan","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib13","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1210\/en.2004-1445","article-title":"Increased pituitary vascular endothelial growth factor-a in dopaminergic D2 receptor knockout female mice","volume":"146","author":"Cristina","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib14","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1210\/en.2006-0657","article-title":"Low dose dopamine agonist administration blocks VEGF mediated vascular permeability without altering VEGFR-2 dependent luteal angiogenesis in a rat ovarian hyperstimulation model","volume":"147","author":"G\u00f3mez","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2165\/00002018-199614040-00003","article-title":"A comparative review of the tolerability profiles of dopamine agonists in the treatment of hyperprolactinaemia and inhibition of lactation","volume":"14","author":"Webster","year":"1996","journal-title":"Drug Saf"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib16","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1093\/humrep\/dem315","article-title":"Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study","volume":"22","author":"\u00c1lvarez","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF03348017","article-title":"Long-term treatment with cabergoline, a new long-lasting ergoline derivate, in idiopathic or tumorous hyperprolactinaemia and outcome of drug-induced pregnancy","volume":"20","author":"Ciccarelli","year":"1997","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1210\/jcem-47-2-290","article-title":"Normal pregnancies after treatment of hyperprolactinemia with bromoergocryptine, despite suspected pituitary tumors","volume":"47","author":"Mornex","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1530\/eje.0.1350413","article-title":"Prolactinomas resistant to bromocriptine: long-term efficacy of quinagolide and outcome of pregnancy","volume":"135","author":"Morange","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib20","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/87895","article-title":"The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor\/vascular endothelial growth factor","volume":"7","author":"Basu","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib21","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1242\/jcs.053124","article-title":"Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2","volume":"122","author":"Sinha","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/humupd\/dmq006","article-title":"Can dopamine agonists reduce the incidence and severity of OHSS in IVF\/ICSI treatment cycles? A systematic review and meta-analysis","volume":"16","author":"Youssef","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib23","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.fertnstert.2014.01.031","article-title":"Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in\u00a0vitro: implications for treatment of ovarian hyperstimulation syndrome with dopamine receptor 2 agonists","volume":"101","author":"Ferrero","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib24","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0002-9440(10)64322-2","article-title":"Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries","volume":"162","author":"Ferrara","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib25","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/humrep\/12.8.1629","article-title":"Role of progesterone in capillary permeability in hyperstimulated rats","volume":"12","author":"Ujioka","year":"1997","journal-title":"Hum Reprod"},{"issue":"Suppl 1","key":"10.1016\/j.fertnstert.2014.07.1240_bib26","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.fertnstert.2003.11.012","article-title":"Gonadotropin releasing hormone agonist administration reduced vascular endothelial growth factor (VEGF), VEGF receptors, and vascular permeability of the ovaries of hyperstimulated rats","volume":"81","author":"Kitajima","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ab.2012.01.012","article-title":"Glyceraldehyde-3-phosphate dehydrogenase: a universal internal control for Western blots in prokaryotic and eukaryotic cells","volume":"423","author":"Wu","year":"2012","journal-title":"Anal Biochem"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib28","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1210\/jc.2007-0409","article-title":"Dopamine agonist cabergoline reduces hemoconcentration and ascites in hyperstimulated women undergoing assisted reproduction","volume":"92","author":"\u00c1lvarez","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib29","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/humrep\/deq005","article-title":"The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trial","volume":"25","author":"Busso","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/0974-1208.69342","article-title":"Effect of bromocriptine on the severity of ovarian hyperstimulation syndrome and outcome in high responders undergoing assisted reproduction","volume":"3","author":"Sherwal","year":"2010","journal-title":"J Hum Reprod Sci"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib31","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1472-6483(10)60401-4","article-title":"Cabergoline reduces the early onset of ovarian hyperstimulation syndrome: a prospective randomized study","volume":"17","author":"Carizza","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib32","first-page":"157","article-title":"Expression of vascular permeability factor\/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development","volume":"146","author":"Kamat","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib33","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.onc.1207034","article-title":"Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2\/p38","volume":"23","author":"Lamalice","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.fertnstert.2014.07.1240_bib34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/oxfordjournals.humrep.a137613","article-title":"Dopamine treatment for severe ovarian hyperstimulation syndrome","volume":"7","author":"Ferraretti","year":"1992","journal-title":"Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214018810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214018810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:16:06Z","timestamp":1758010566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028214018810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0015028214018810"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.07.1240","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.07.1240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}