{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:56:58Z","timestamp":1784264218452,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":3306,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.fertnstert.2014.09.020","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T16:20:39Z","timestamp":1413994839000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Biomarkers of exposure to molybdenum and other metals in\u00a0relation to testosterone among men from the United States National Health and\u00a0Nutrition Examination Survey 2011\u20132012"],"prefix":"10.1016","volume":"103","author":[{"given":"Ryan C.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Meeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2014.09.020_bib1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.fertnstert.2008.09.044","article-title":"Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum","volume":"93","author":"Meeker","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/15287394.2012.690704","article-title":"Assessment of essential and nonessential metals and different metal exposure biomarkers in the human placenta in a population from the south of Portugal","volume":"75","author":"Serafim","year":"2012","journal-title":"J\u00a0Toxicol Environ Health A"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib3","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1289\/ehp.11490","article-title":"Cadmium, lead, and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant","volume":"116","author":"Meeker","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib4","series-title":"Laboratory procedures manual, total testosterone in serum, NHANES 2011\u20132012","author":"Centers for Disease Control and Prevention","year":"2014"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jsbmb.2008.12.022","article-title":"The role of testosterone in the metabolic syndrome: a review","volume":"114","author":"Saad","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2337\/dc06-1579","article-title":"Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)","volume":"30","author":"Selvin","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib7","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1464-410X.2008.07933.x","article-title":"Metabolic and cardiovascular effects of androgen deprivation therapy","volume":"102","author":"Hakimian","year":"2008","journal-title":"BJU Int"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000176049","article-title":"Testosterone, bone and osteoporosis","volume":"37","author":"Tuck","year":"2009","journal-title":"Front Horm Res"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11914-007-0013-1","article-title":"Bone loss in patients with breast or prostate cancer","volume":"5","author":"Hu","year":"2007","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yfrne.2009.04.015","article-title":"Protective actions of sex steroid hormones in Alzheimer's disease","volume":"30","author":"Pike","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000176051","article-title":"Testosterone effects on cognition in health and disease","volume":"37","author":"Cherrier","year":"2009","journal-title":"Front Horm Res"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/jc.2007-1792","article-title":"Low serum testosterone and mortality in older men","volume":"93","author":"Laughlin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib13","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1001\/archinte.166.15.1660","article-title":"Low serum testosterone and mortality in male veterans","volume":"166","author":"Shores","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/15287390252807975","article-title":"Alterations of serum hormone levels in male workers occupationally exposed to cadmium","volume":"65","author":"Zeng","year":"2002","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.envres.2004.02.004","article-title":"Impact of cadmium exposure on male sex hormones: a population-based study in China","volume":"96","author":"Zeng","year":"2004","journal-title":"Environ Res"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10534-004-1689-7","article-title":"Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subjects","volume":"17","author":"Jurasovi\u0107","year":"2004","journal-title":"Biometals"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.envres.2007.05.011","article-title":"Reproductive toxicity of low-level lead exposure in men","volume":"105","author":"Telisman","year":"2007","journal-title":"Environ Res"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib18","first-page":"790","article-title":"Elevated serum testosterone levels and risk of hepatocellular carcinoma","volume":"53","author":"Yu","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0083-6729(05)70014-5","article-title":"The role of alcohol and steroid hormones in human aggression","volume":"70","author":"von der Pahlen","year":"2005","journal-title":"Vitam Horm"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib20","unstructured":"Centers for Disease Control and Prevention. NHANES 2011\u20132012 overview. Available from: http:\/\/www.cdc.gov\/nchs\/nhanes\/nhanes2011-2012\/overview_g.htm. Accessed June 9,\u00a02014."},{"key":"10.1016\/j.fertnstert.2014.09.020_bib21","unstructured":"Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey, 2011\u20132012 data documentation, codebook, and frequencies, demographic variables and sample weights. Available from: http:\/\/wwwn.cdc.gov\/nchs\/nhanes\/2011-2012\/DEMO_G.htm#INDFMPIR. Accessed June 9,\u00a02014."},{"key":"10.1016\/j.fertnstert.2014.09.020_bib22","unstructured":"Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey, 2011\u20132012 data documentation, codebook, and frequencies, body measures. Available from: http:\/\/wwwn.cdc.gov\/nchs\/nhanes\/2011-2012\/BMX_G.htm. Accessed June 9,\u00a02014."},{"key":"10.1016\/j.fertnstert.2014.09.020_bib23","series-title":"Laboratory procedures manual, creatinine in urine, NHANES 2011\u20132012","author":"Centers for Disease Control and Prevention","year":"2011"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib24","series-title":"Laboratory procedures manual, antimony, arsenic, barium, beryllium, cadmium, cesium, cobalt, lead, manganese, molybdenum, platinum, strontium, thallium, tin, tungsten, and uranium in urine, NHANES 2011\u20132012","author":"Centers for Disease Control and Prevention","year":"2012"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib25","series-title":"Laboratory procedures manual, zinc, copper, and selenium in serum, NHANES 2011\u20132012","author":"Centers for Disease Control and Prevention","year":"2013"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib26","series-title":"Laboratory procedures manual, cadmium, lead, manganese, mercury, and selenium in whole blood, NHANES 2011\u20132012","author":"Centers for Disease Control and Prevention","year":"2012"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib27","series-title":"Laboratory procedures manual, cotinine in serum, NHANES 2011\u20132012","author":"Centers for Disease Control and Prevention","year":"2008"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1289\/ehp.7337","article-title":"Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements","volume":"113","author":"Barr","year":"2005","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib29","unstructured":"World Health Organization. BMI classification. Available from: http:\/\/apps.who.int\/bmi\/index.jsp?introPage=intro_3.html. Accessed June 9,\u00a02014."},{"key":"10.1016\/j.fertnstert.2014.09.020_bib30","series-title":"Analytical reporting guidelines: The Third National Health and Nutrition Examination Survey, NHANES III (1988\u20131994)","author":"National Center for Health Statistics","year":"1996"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1476-069X-12-117","article-title":"Blood cadmium is elevated in iron deficient U.S. children: a cross-sectional study","volume":"12","author":"Silver","year":"2013","journal-title":"Environ Health"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/pr.57.1.3","article-title":"Metabolism and disposition kinetics of nicotine","volume":"57","author":"Hukkanen","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib33","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.2105\/AJPH.81.9.1166","article-title":"Epidemiologic studies utilizing surveys: accounting for the sampling design","volume":"81","author":"Korn","year":"1991","journal-title":"Am J Public Health"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib34","series-title":"National Health and Nutrition Examination Survey: Analytic Guidelines, 1999\u20132010","author":"National Center for Health Statistics","year":"2013"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2164\/jandrol.106.001545","article-title":"Relationships between serum hormone levels and semen quality among men from an infertility clinic","volume":"28","author":"Meeker","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.reprotox.2013.06.062","article-title":"Associations of urinary metal concentrations and circulating testosterone in Chinese men","volume":"41","author":"Zeng","year":"2013","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib37","first-page":"289","article-title":"A case report of acute human molybdenum toxicity from a dietary molybdenum supplement\u2014a new member of the \u201cLucor metallicum\u201d family","volume":"50","author":"Momcilovi\u0107","year":"1999","journal-title":"Arh Hig Rada Toksikol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib38","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3168\/jds.S0022-0302(51)91802-4","article-title":"The effect of orally administered molybdenum on growth, spermatogenesis and testes histology of young dairy bulls","volume":"34","author":"Thomas","year":"1951","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/jn\/54.2.215","article-title":"The effect of dietary molybdenum upon growth, hemoglobin, reproduction and lactation of rats","volume":"54","author":"Jeter","year":"1954","journal-title":"J Nutr"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/(SICI)1099-1263(199905\/06)19:3<185::AID-JAT555>3.0.CO;2-Z","article-title":"Assessment of molybdenum toxicity in humans","volume":"19","author":"Vyskocil","year":"1999","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib41","first-page":"28","article-title":"The influence of experimentally induced copper deficiency on the fertility of rams. I. Semen parameters and peripheral plasma androgen concentration","volume":"60","author":"Van Niekerk","year":"1989","journal-title":"J S Afr Vet Assoc"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.reprotox.2004.07.006","article-title":"The effects of tetrathiomolybdate (TTM, NSC-714598) and copper supplementation on fertility and early embryonic development in rats","volume":"19","author":"Lyubimov","year":"2004","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1013193013142","article-title":"Effects of molybdenum on fertility of male rats","volume":"15","author":"Pandey","year":"2002","journal-title":"Biometals"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0021-9975(03)00065-3","article-title":"Molybdenum-associated pituitary endocrinopathy in sheep treated with ammonium tetrathiomolybdate","volume":"130","author":"Haywood","year":"2004","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1079\/BJN19980056","article-title":"Metal (molybdenum, copper) accumulation and retention in brain, pituitary and other organs of ammonium tetrathiomolybdate-treated sheep","volume":"79","author":"Haywood","year":"1998","journal-title":"Br J Nutr"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.ph.46.030184.000435","article-title":"Effects of molybdate and endogenous inhibitors on steroid-receptor inactivation, transformation, and translocation","volume":"46","author":"Dahmer","year":"1984","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib47","series-title":"Toxicological profile for\u00a0lead","author":"Agency for Toxic Substances and Disease Registry","year":"2007"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib48","series-title":"Toxicological profile for cadmium","author":"Agency for Toxic Substances and Disease Registry","year":"2012"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib49","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/096032719000900205","article-title":"Occupational cadmium exposure and testicular endocrine function","volume":"9","author":"Mason","year":"1990","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1289\/ehp.0010845","article-title":"Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men","volume":"108","author":"Telisman","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib51","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/096032719000900602","article-title":"Chronic occupational lead exposure and testicular endocrine function","volume":"9","author":"McGregor","year":"1990","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib52","first-page":"485","article-title":"Male endocrine functions in workers with moderate exposure to lead","volume":"48","author":"Ng","year":"1991","journal-title":"Br J Ind Med"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib53","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/oem.53.6.411","article-title":"Semen quality of men employed at a lead smelter","volume":"53","author":"Alexander","year":"1996","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib54","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2458-8-72","article-title":"The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men","volume":"8","author":"Menke","year":"2008","journal-title":"BMC Public Health"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib55","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1080\/15287390802209525","article-title":"Biomonitoring of lead exposure\u2014alternatives to blood","volume":"71","author":"Bergdahl","year":"2008","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib56","first-page":"56","article-title":"Blood selenium levels and contribution of food groups to selenium intake in adolescent girls in Iceland","author":"Gudmundsdottir","year":"2012","journal-title":"Food Nutr Res"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib57","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/jc.2003-031287","article-title":"Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry","volume":"89","author":"Wang","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2014.09.020_bib58","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.mam.2005.07.003","article-title":"Nutritional aspects of manganese homeostasis","volume":"26","author":"Aschner","year":"2005","journal-title":"Mol Aspects Med"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214021724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028214021724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:17:08Z","timestamp":1758010628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028214021724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0015028214021724"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.09.020","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers of exposure to molybdenum and other metals in\u00a0relation to testosterone among men from the United States National Health and\u00a0Nutrition Examination Survey 2011\u20132012","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2014.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}