{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:21:38Z","timestamp":1784240498547,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":2460,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","fertstert.org","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.fertnstert.2015.06.001","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T09:05:51Z","timestamp":1434704751000},"page":"649-654","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Postmolar gestational trophoblastic neoplasia: beyond the traditional risk factors"],"prefix":"10.1016","volume":"104","author":[{"given":"Mahmood","family":"Bakhtiyari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Mirzamoradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichehr","family":"Kimyaiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Aghaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammd Ali","family":"Mansournia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Ashrafi-vand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Sadat","family":"Sarfjoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2015.06.001_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/00313020601137367","article-title":"The pathology of gestational trophoblastic disease: recent advances","volume":"39","author":"Wells","year":"2007","journal-title":"Pathology"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S1521-6934(03)00094-4","article-title":"Pathology of gestational trophoblastic diseases","volume":"17","author":"Cheung","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib3","doi-asserted-by":"crossref","first-page":"302.e1","DOI":"10.1016\/j.ajog.2007.09.036","article-title":"Clinical presentation of hydatidiform mole in northern Italy: has it changed in the last 20 years?","volume":"198","author":"Mangili","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ygyno.2011.01.002","article-title":"Increase in the incidence of gestational trophoblastic disease in The Netherlands","volume":"121","author":"Lybol","year":"2011","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ajog.2010.06.073","article-title":"Gestational trophoblastic disease. I. epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole","volume":"203","author":"Lurain","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0020-7292(00)00300-3","article-title":"Staging classifications and clinical practice guidelines for gynaecological cancers","volume":"70","author":"Benedet","year":"2000","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ygyno.2005.06.032","article-title":"The curative effect of a second curettage in persistent trophoblastic disease: a retrospective cohort survey","volume":"99","author":"van Trommel","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/oxfordjournals.humrep.a136622","article-title":"Incidence of gestational trophoblastic disease by regional registration in Japan","volume":"2","author":"Takeuchi","year":"1987","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib9","first-page":"764","article-title":"Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome","volume":"51","author":"Hancock","year":"2006","journal-title":"J Reprod Med"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-9378(85)80115-0","article-title":"Risk factors for gestational trophoblastic neoplasia","volume":"153","author":"Messerli","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1471-0528.1976.tb00774.x","article-title":"Relationship of oral contraception to development of trophoblastic tumour after evacuation of a hydatidiform mole","volume":"83","author":"Stone","year":"1976","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib13","first-page":"1004","article-title":"Case-control study of gestational choriocarcinoma","volume":"48","author":"Buckley","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib14","first-page":"81","article-title":"Gestational trophoblastic disease. Subsequent pregnancy outcome, including repeat molar pregnancy","volume":"43","author":"Berkowitz","year":"1998","journal-title":"J Reprod Med"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/01.AOG.0000174583.51617.25","article-title":"Postevacuation hCG levels and risk of gestational trophoblastic neoplasia in women with complete molar pregnancy","volume":"106","author":"Wolfberg","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ygyno.2004.05.013","article-title":"Diagnosis and treatment of gestational trophoblastic disease: ACOG Practice Bulletin No. 53","volume":"93","author":"Soper","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib17","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1093\/clinchem\/43.12.2233","article-title":"Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites","volume":"43","author":"Cole","year":"1997","journal-title":"Clin Chem"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/sim.2331","article-title":"Dichotomizing continuous predictors in multiple regression: a bad idea","volume":"25","author":"Royston","year":"2006","journal-title":"Stat Med"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0261-3794(99)00028-1","article-title":"Loess: a nonparametric, graphical tool for depicting relationships between variables","volume":"19","author":"Jacoby","year":"2000","journal-title":"Elect Stud"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib20","series-title":"Multivariable model-building: a pragmatic approach to regression anaylsis based on fractional polynomials for modelling continuous variables","author":"Royston","year":"2008"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/sim.6537","article-title":"Penalization, bias reduction, and default priors in logistic and related categorical and survival regressions","author":"Greenland","year":"2015","journal-title":"Stats Med"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib22","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/sim.1047","article-title":"A solution to the problem of separation in logistic regression","volume":"21","author":"Heinze","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ygyno.2014.04.002","article-title":"Preoperative quality of life and surgical outcomes in gynecologic oncology patients: a new predictor of operative risk?","volume":"133","author":"Doll","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib25","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/01.hjh.0000217845.57466.cc","article-title":"Risk prediction and finding new independent prognostic factors","volume":"24","author":"D\u2019Agostino","year":"2006","journal-title":"J Hypertens"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib26","first-page":"6","article-title":"Linear regression of postevacuation serum human chorionic gonadotropin concentrations predicts postmolar gestational trophoblastic neoplasia","volume":"1150","author":"Lybol","year":"2013","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejogrb.2011.10.003","article-title":"Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study","volume":"160","author":"Kim","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib28","first-page":"1003","article-title":"[Risk factors for gestational trophoblastic tumors following complete hydatidiform mole]","volume":"73","author":"Grzybowski","year":"2002","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib29","first-page":"221","article-title":"The role of contraception in the development of postmolar gestational trophoblastic tumor","volume":"78","author":"Deicas","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib30","first-page":"81","article-title":"Risk factors for persistent gestational trophoblastic neoplasia","volume":"9","author":"Kuyumcuoglu","year":"2010","journal-title":"J Exper Therap Oncol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib31","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1479-828X.2009.01085.x","article-title":"Analysis of risk factors for persistent gestational trophoblastic disease","volume":"49","author":"Khoo","year":"2009","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib32","first-page":"1039","article-title":"Risk factors for gestational trophoblastic disease: a separate analysis of complete and partial hydatidiform moles","volume":"78","author":"Parazzini","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib33","first-page":"447","article-title":"Host and risk factors for gestational trophoblastic disease: a hospital-based analysis from India","volume":"9","author":"Kumar","year":"2003","journal-title":"Signature"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib34","series-title":"Introduction to the logistic regression model, in applied logistic regression","author":"Hosmer","year":"2000"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib35","series-title":"Monte Carlo methods in Bayesian computation","author":"Shao","year":"2000"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ygyno.2011.10.035","article-title":"Prediction of persistent gestational trophobalstic neoplasia: the role of hCG level and ratio in 2 weeks after evacuation of complete mole","volume":"124","author":"Kang","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib37","first-page":"243","article-title":"Normal human chorionic gonadotropin regression curves in uneventful postmolar patients","volume":"57","author":"Kizaki","year":"2011","journal-title":"J Reprod Med"},{"key":"10.1016\/j.fertnstert.2015.06.001_bib38","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/oxfordjournals.aje.a010240","article-title":"Problems due to small samples and sparse data in conditional logistic regression analysis","volume":"151","author":"Greenland","year":"2000","journal-title":"Am J Epidemiol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028215003908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028215003908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:33:44Z","timestamp":1666485224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028215003908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0015028215003908"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2015.06.001","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postmolar gestational trophoblastic neoplasia: beyond the traditional risk factors","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2015.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}