{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:27Z","timestamp":1790704887416,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":2094,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","fertstert.org","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.fertnstert.2016.06.002","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T14:46:49Z","timestamp":1467038809000},"page":"653-659.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Standard human chorionic gonadotropin versus double trigger for final oocyte maturation results in different granulosa cells gene expressions: a pilot study"],"prefix":"10.1016","volume":"106","author":[{"given":"Jigal","family":"Haas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby","family":"Ophir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Barzilay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Machtinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Yung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Orvieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Hourvitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2016.06.002_bib1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/humupd\/dmr008","article-title":"GnRH agonist for triggering of final oocyte maturation: time for a change of practice?","volume":"17","author":"Humaidan","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1472-6483(10)60653-0","article-title":"GnRH agonist to induce oocyte maturation during IVF in patients at high risk of OHSS","volume":"13","author":"Engmann","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S1472-6483(10)60006-5","article-title":"Luteal phase rescue in high-risk OHSS patients by GnRHa triggering in combination with low-dose HCG: a pilot study","volume":"18","author":"Humaidan","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib4","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1093\/humrep\/dep246","article-title":"GnRHa to trigger final oocyte maturation: a time to reconsider","volume":"24","author":"Humaidan","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1757-2215-6-77","article-title":"Ovarian hyperstimulation syndrome\u2014an optimal solution for an unresolved enigma","volume":"6","author":"Orvieto","year":"2013","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0015-0282(98)00484-1","article-title":"The pathogenesis of ovarian hyperstimulation syndrome: in\u00a0vivo studies investigating the role of interleukin-1beta, interleukin-6, and vascular endothelial growth factor","volume":"71","author":"Pellicer","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0140-6736(94)93001-5","article-title":"Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome","volume":"344","author":"McClure","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib8","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/humrep\/deh765","article-title":"GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF\/ICSI cycles: a prospective randomized study","volume":"20","author":"Humaidan","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib9","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1093\/humrep\/dei150","article-title":"A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists","volume":"20","author":"Kolibianakis","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/humupd\/dmi045","article-title":"GnRH agonist for triggering final oocyte maturation in the GnRH antagonist ovarian hyperstimulation protocol: a systematic review and meta-analysis","volume":"12","author":"Griesinger","year":"2006","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/mrd.20281","article-title":"The potential role of gap junction communication between cumulus cells and bovine oocytes during in\u00a0vitro maturation","volume":"71","author":"Atef","year":"2005","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/mrd.20781","article-title":"EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes","volume":"75","author":"Downs","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1530\/REP-12-0191","article-title":"Signaling pathways regulating FSH- and amphiregulin-induced meiotic resumption and cumulus cell expansion in the pig","volume":"144","author":"Prochazka","year":"2012","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib14","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.fertnstert.2011.01.019","article-title":"Follicle-stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in\u00a0vitro fertilization cycles: a randomized, double-blind, placebo-controlled trial","volume":"95","author":"Lamb","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1757-2215-7-77","article-title":"Co-administration of GnRH-agonist and hCG for final oocyte maturation (double trigger) in patients with low number of oocytes retrieved per number of preovulatory follicles\u2013a preliminary report","volume":"7","author":"Haas","year":"2014","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/09513590.2014.978850","article-title":"Co-administration of GnRH-agonist and hCG, for final oocyte maturation (double trigger), in patients with low proportion of mature oocytes","volume":"31","author":"Zilberberg","year":"2015","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib17","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/humrep\/des037","article-title":"Empty follicle syndrome: successful treatment in a recurrent case and review of the literature","volume":"27","author":"Beck-Fruchter","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.rbmo.2012.01.023","article-title":"Anti-Mullerian hormone is highly expressed and secreted from cumulus granulosa cells of stimulated preovulatory immature and atretic oocytes","volume":"24","author":"Kedem-Dickman","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib19","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.fertnstert.2011.12.027","article-title":"High expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells is in correlation with decreased fertilization","volume":"97","author":"Maman","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/molehr\/gar010","article-title":"Expression and regulation of sFRP family members in human granulosa cells","volume":"17","author":"Maman","year":"2011","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mce.2010.07.019","article-title":"ADAMTS-1: a new human ovulatory gene and a cumulus marker for fertilization capacity","volume":"328","author":"Yung","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib22","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/humrep\/des096","article-title":"Efficiency and purity provided by the existing methods for the isolation of luteinized granulosa cells: a comparative study","volume":"27","author":"Ferrero","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib23","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/humrep\/del119","article-title":"Hormonal characteristics of follicular fluid from women receiving either GnRH agonist or hCG for ovulation induction","volume":"21","author":"Andersen","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib24","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/humrep\/dei475","article-title":"Serum inhibin A, VEGF and TNFalpha levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial","volume":"21","author":"Babayof","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib25","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1210\/jcem.87.2.8197","article-title":"Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in\u00a0vitro fertilization","volume":"87","author":"Fauser","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib26","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1093\/oxfordjournals.humrep.a135865","article-title":"Ovarian stimulation in women undergoing in-vitro fertilization and embryo transfer using recombinant human follicle stimulating hormone (Gonal-F) in non-down-regulated cycles","volume":"10","author":"Strowitzki","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0015-0282(98)00447-6","article-title":"Serum vascular endothelial growth factor concentrations in in\u00a0vitro fertilization cycles predict the risk of ovarian hyperstimulation syndrome","volume":"71","author":"Agrawal","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib28","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0015-0282(02)04243-7","article-title":"Serum vascular endothelial growth factor levels are poorly predictive of subsequent ovarian hyperstimulation syndrome in highly responsive women undergoing assisted conception","volume":"78","author":"Mathur","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0301-2115(00)00460-7","volume":"96","author":"Enskog","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib30","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.fertnstert.2008.08.118","article-title":"Differential regulation of VEGF after final oocyte maturation with GnRH agonist versus hCG: a rationale for OHSS reduction","volume":"91","author":"Cerrillo","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib31","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.fertnstert.2010.12.054","article-title":"Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome","volume":"95","author":"Cerrillo","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib32","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.fertnstert.2011.02.013","article-title":"Levels of the epidermal growth factor-like peptide amphiregulin in follicular fluid reflect the mode of triggering ovulation: a comparison between gonadotrophin-releasing hormone agonist and urinary human chorionic gonadotrophin","volume":"95","author":"Humaidan","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib33","doi-asserted-by":"crossref","first-page":"e90359","DOI":"10.1371\/journal.pone.0090359","article-title":"GnRH agonist vs. hCG for triggering of ovulation\u2013differential effects on gene expression in human granulosa cells","volume":"9","author":"Haas","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib34","doi-asserted-by":"crossref","first-page":"25992","DOI":"10.1074\/jbc.270.43.25992","article-title":"Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop","volume":"270","author":"Becerra","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib35","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/j.lfs.2005.05.048","article-title":"Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells","volume":"77","author":"Takenaka","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib36","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/molehr\/gas046","article-title":"Hormonal regulation of pigment epithelium-derived factor (PEDF) in granulosa cells","volume":"19","author":"Chuderland","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib37","doi-asserted-by":"crossref","first-page":"E258","DOI":"10.1210\/jc.2012-3037","article-title":"The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice","volume":"98","author":"Chuderland","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib38","doi-asserted-by":"crossref","first-page":"E1428","DOI":"10.1210\/jc.2015-2312","article-title":"GnRH agonist triggering modulates PEDF to VEGF ratio inversely to hCG in granulosa cells","volume":"100","author":"Miller","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib39","first-page":"22","article-title":"GnRH and GnRH receptors in the pathophysiology of the human female reproductive system","author":"Maggi","year":"2016","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib40","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1210\/jc.2006-1147","article-title":"Immunolocalization of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and type I GnRH receptor during follicular development in the human ovary","volume":"91","author":"Choi","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib41","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1210\/jc.2008-0127","article-title":"Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells","volume":"93","author":"Hong","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib42","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.1092463","article-title":"EGF-like growth factors as mediators of LH action in the ovulatory follicle","volume":"303","author":"Park","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib43","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1071\/RD12125","article-title":"Effects of FSH on the expression of receptors for oocyte-secreted factors and members of the EGF-like family during in\u00a0vitro maturation in cattle","volume":"25","author":"Caixeta","year":"2013","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/humrep\/deq290","article-title":"In\u00a0vitro maturation of human germinal vesicle-stage oocytes: role of epidermal growth factor-like growth factors in the culture medium","volume":"26","author":"Ben-Ami","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1996.0001q.x","article-title":"Connections with connexins: the molecular basis of direct intercellular signaling","volume":"238","author":"Bruzzone","year":"1996","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib46","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1582-4934.2008.00373.x","article-title":"Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality","volume":"13","author":"Wang","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10815-007-9155-4","article-title":"Reduction of connexin 43 in human cumulus cells yields good embryo competence during ICSI","volume":"24","author":"Hasegawa","year":"2007","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2016.06.002_bib48","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/molehr\/gau013","article-title":"Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply","volume":"20","author":"Sugimura","year":"2014","journal-title":"Mol Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216612967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216612967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T06:11:07Z","timestamp":1666505467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028216612967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0015028216612967"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2016.06.002","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Standard human chorionic gonadotropin versus double trigger for final oocyte maturation results in different granulosa cells gene expressions: a pilot study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2016.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a92016 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}