{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:26:26Z","timestamp":1785252386308,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":1941,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","fertstert.org","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.fertnstert.2016.10.030","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T14:59:39Z","timestamp":1479308379000},"page":"379-386.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Use of Utrogestan during controlled ovarian hyperstimulation in normally ovulating women undergoing in\u00a0vitro fertilization or intracytoplasmic sperm injection treatments in combination with a \u201cfreeze all\u201d strategy: a randomized controlled dose-finding study of 100\u00a0mg versus 200\u00a0mg"],"prefix":"10.1016","volume":"107","author":[{"given":"Xiuxian","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-6748","authenticated-orcid":false,"given":"Yonglun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2016.10.030_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0015-0282(16)49160-0","article-title":"In\u00a0vitro fertilization management and results in stimulated cycles with spontaneous luteinizing hormone discharge","volume":"45","author":"Eibschitz","year":"1986","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib2","doi-asserted-by":"crossref","first-page":"e106854","DOI":"10.1371\/journal.pone.0106854","article-title":"Comparisons of GnRH antagonist versus GnRH agonist protocol in supposed normal ovarian responders undergoing IVF: a systematic review and meta-analysis","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib3","doi-asserted-by":"crossref","first-page":"e909","DOI":"10.1097\/MD.0000000000000909","article-title":"Utrogestan as an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in\u00a0vitro fertilization","volume":"94","author":"Zhu","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib4","first-page":"384","article-title":"Effect of progesterone used to prevent LH surges in controlled ovarian stimulation","volume":"35","author":"Zhu","year":"2015","journal-title":"Reprod Contracept"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib5","first-page":"28","article-title":"The Utrogestan and hMG protocol in patients with polycystic ovarian syndrome undergoing controlled ovarian hyperstimulation during IVF\/ICSI treatments","volume":"95","author":"Zhu","year":"2016","journal-title":"Medicine"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/09513590701504574","article-title":"LH neither too high nor too low","volume":"23","author":"Barri","year":"2007","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.rbmo.2011.03.023","article-title":"Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective","volume":"23","author":"Wong","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib8","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/humrep\/17.4.874","article-title":"GnRH antagonist in assisted reproduction: a Cochrane review","volume":"17","author":"Al-Inany","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib9","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/humrep\/del219","article-title":"A relative reduction in mid-follicular LH concentrations during GnRH agonist IVF\/ICSI cycles leads to lower live birth rates","volume":"21","author":"Lahoud","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0015-0282(00)01745-3","article-title":"Role of periovulatory luteinizing hormone concentrations during assisted reproductive technology cycles stimulated exclusively with recombinant follicle-stimulating hormone","volume":"75","author":"Esposito","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib11","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1185\/03007990802374815","article-title":"Follicular development induced by recombinant luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in anovulatory women with LH and FSH deficiency: evidence of a threshold effect","volume":"24","author":"O\u2019Dea","year":"2008","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib12","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1093\/humrep\/17.8.2016","article-title":"Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation","volume":"17","author":"Humaidan","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib13","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1093\/humrep\/deh535","article-title":"Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF","volume":"19","author":"McKenzie","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib14","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/humrep\/del065","article-title":"The human cumulus-oocyte complex gene-expression profile","volume":"21","author":"Assou","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib15","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/humrep\/15.5.1003","article-title":"Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotrophic women undergoing assisted reproduction","volume":"15","author":"Westergaard","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.fertnstert.2004.07.969","article-title":"Evaluation of two doses of recombinant luteinizing hormone supplementation in an unselected group of women undergoing follicular stimulation for in\u00a0vitro fertilization","volume":"83","author":"Lisi","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib17","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1210\/jcem-28-12-1763","article-title":"Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man","volume":"28","author":"Yen","year":"1968","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib18","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1530\/acta.0.0900696","article-title":"Differential properties of human chorionic gonadotrophin and human luteinizing hormone binding to plasma membranes of bovine corpora lutea","volume":"90","author":"Rao","year":"1979","journal-title":"Acta Endocrinol (Copenh)"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib19","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/bmj.280.6217.825","article-title":"Absorption and metabolism of oral progesterone","volume":"280","author":"Whitehead","year":"1980","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0015-0282(99)00272-1","article-title":"Micronized progesterone: clinical indications and comparison with current treatments","volume":"72","author":"Fitzpatrick","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib21","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0015-0282(16)54713-X","article-title":"Comparative bioavailability of orally and vaginally administered progesterone","volume":"56","author":"Norman","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0015-0282(16)56031-2","article-title":"The absorption of oral micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone","volume":"60","author":"Simon","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0022-4731(87)90078-1","article-title":"Radioimmunoassay of plasma progesterone after oral administration of micronized progesterone","volume":"26","author":"Nahoul","year":"1987","journal-title":"J Steroid Biochem"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0149-2918(00)88267-3","article-title":"Oral micronized progesterone","volume":"21","author":"de Ligni\u00e8res","year":"1999","journal-title":"Clin Ther"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib25","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1210\/endo-109-5-1414","article-title":"The endocrine basis of the synergistic suppression of luteinizing hormone by estradiol and progesterone","volume":"109","author":"Goodman","year":"1981","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib26","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1093\/humrep\/13.11.3023","volume":"13","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/humrep\/del445","article-title":"Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients","volume":"22","author":"Smitz","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib28","first-page":"74","article-title":"The effects of progesterone on oocyte maturation and embryo development","volume":"7","author":"Salehnia","year":"2013","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib29","first-page":"319","article-title":"Effect of follicular steroids on the maturation and fertilization of mammalian oocytes","volume":"56","author":"Moor","year":"1980","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib30","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1095\/biolreprod.110.087411","article-title":"Expression, regulation, and function of progesterone receptors in bovine cumulus oocyte complexes during in\u00a0vitro maturation","volume":"84","author":"Aparicio","year":"2011","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1530\/rep.0.1260501","article-title":"Effects of stage of oestrous cycle and progesterone supplementation during culture on maturation of canine oocytes in\u00a0vitro","volume":"126","author":"Willingham-Rocky","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib32","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.theriogenology.2006.01.008","article-title":"In\u00a0vitro canine oocyte nuclear maturation in homologous oviductal cell co-culture with hormone-supplemented media","volume":"66","author":"Vannucchi","year":"2006","journal-title":"Theriogenology"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib33","first-page":"83","article-title":"Effect of preovulatory endocrine events upon maturation of oocytes of domestic bitches","volume":"51","author":"Hewitt","year":"1997","journal-title":"J Reprod Fertil Suppl"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0093-691X(82)90100-5","article-title":"Effect of gonadotropins, steroids and culture media on bovine oocyte maturation in\u00a0vitro","volume":"18","author":"Fukui","year":"1982","journal-title":"Theriogenology"},{"key":"10.1016\/j.fertnstert.2016.10.030_bib35","first-page":"21","article-title":"The effect of progesterone on the in\u00a0vitro maturation and developmental competence of mouse germinal vesicle oocytes","volume":"3","author":"Zavareh","year":"2009","journal-title":"Int J Fertil Steril"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216629539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216629539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T06:45:06Z","timestamp":1666507506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028216629539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0015028216629539"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2016.10.030","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of Utrogestan during controlled ovarian hyperstimulation in normally ovulating women undergoing in\u00a0vitro fertilization or intracytoplasmic sperm injection treatments in combination with a \u201cfreeze all\u201d strategy: a randomized controlled dose-finding study of 100\u00a0mg versus 200\u00a0mg","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2016.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92016 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}