{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:00Z","timestamp":1790704860205,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":1913,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","fertstert.org","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.fertnstert.2016.12.007","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T13:04:55Z","timestamp":1484571895000},"page":"622-631.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":220,"title":["Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"107","author":[{"given":"Xiao-Yan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Zhong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2016.12.007_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1056\/NEJMc1404371","article-title":"Monitoring health outcomes of assisted reproductive technology","volume":"371","author":"Kissin","year":"2014","journal-title":"New Engl J Med"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature05918","article-title":"Stability and flexibility of epigenetic gene regulation in mammalian development","volume":"447","author":"Reik","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrg3142","article-title":"Epigenetics and the environment: emerging patterns and implications","volume":"13","author":"Feil","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1242\/dev.060426","article-title":"Human pre-implantation embryo development","volume":"139","author":"Niakan","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0140-6736(08)61041-7","article-title":"Effects of technology or maternal factors on perinatal outcome after assisted fertilisation: a population-based cohort study","volume":"372","author":"Romundstad","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/humupd\/dmt006","article-title":"Assisted reproductive technology and birth defects: a systematic review and meta-analysis","volume":"19","author":"Hansen","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib8","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/bmj.298.6673.564","article-title":"Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease","volume":"298","author":"Barker","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J Intern Med"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1152\/physrev.00015.2015","article-title":"In utero origins of hypertension: mechanisms and targets for therapy","volume":"96","author":"Morton","year":"2016","journal-title":"Physiol Rev"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib11","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1172\/JCI68943","article-title":"Mice generated by in\u00a0vitro fertilization exhibit vascular dysfunction and shortened life span","volume":"123","author":"Rexhaj","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1530\/REP-13-0354","article-title":"Effects of the use of assisted reproduction and high-caloric diet consumption on body weight and cardiovascular health of juvenile mouse offspring","volume":"147","author":"Schenewerk","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib13","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1073\/pnas.0610317104","article-title":"Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure","volume":"104","author":"Watkins","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib14","doi-asserted-by":"crossref","first-page":"H1151","DOI":"10.1152\/ajpheart.00621.2014","article-title":"Prevention of vascular dysfunction and arterial hypertension in mice generated by assisted reproductive technologies by addition of melatonin to culture media","volume":"309","author":"Rexhaj","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1095\/biolreprod.109.082826","article-title":"Glucose parameters are altered in mouse offspring produced by assisted reproductive technologies and somatic cell nuclear transfer","volume":"83","author":"Scott","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1095\/biolreprod.113.113134","article-title":"In\u00a0vitro fertilization affects growth and glucose metabolism in a sex-specific manner in an outbred mouse model","volume":"90","author":"Donjacour","year":"2014","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1476-511X-12-5","article-title":"Alteration of fatty acid metabolism in the liver, adipose tissue, and testis of male mice conceived through assisted reproductive technologies: fatty acid metabolism in ART mice","volume":"12","author":"Wang","year":"2013","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.fertnstert.2012.12.015","article-title":"Cardiometabolic health of children conceived by assisted reproductive technologies","volume":"99","author":"Yeung","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib19","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/eurheartj\/ehv145","article-title":"Cardiovascular dysfunction in children conceived by assisted reproductive technologies","volume":"36","author":"Scherrer","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib20","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1111\/j.1651-2227.2008.00959.x","article-title":"Abnormal vessel morphology in boys born after intracytoplasmic sperm injection","volume":"97","author":"Wikstrand","year":"2008","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib21","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3390\/nu7031378","article-title":"The periconceptional environment and cardiovascular disease: Does in\u00a0vitro embryo culture and transfer influence cardiovascular development and health?","volume":"7","author":"Padhee","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1095\/biolreprod.114.120659","article-title":"Altered protein expression profiles in umbilical veins: insights into vascular dysfunctions of the children born after in\u00a0vitro fertilization","volume":"91","author":"Gao","year":"2014","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib23","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1161\/CIRCULATIONAHA.105.540906","article-title":"Risk of high blood pressure among young men increases with the degree of immaturity at birth","volume":"112","author":"Johansson","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/CIRCULATIONAHA.107.710715","article-title":"Perinatal risk factors for ischemic heart disease: Disentangling the roles of birth weight and preterm birth","volume":"117","author":"Kaijser","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/HYPERTENSIONAHA.111.181784","article-title":"Systematic review and meta-analysis of preterm birth and later systolic blood pressure","volume":"59","author":"De Jong","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib26","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.fertnstert.2014.06.048","article-title":"Is subfertility or fertility treatment associated with long-term growth in the offspring? A cohort study","volume":"102","author":"Bay","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib27","doi-asserted-by":"crossref","first-page":"E2494","DOI":"10.1210\/jc.2014-2349","article-title":"Cardiovascular dysfunction in offspring of ovarian-hyperstimulated women and effects of estradiol and progesterone: a retrospective cohort study and proteomics analysis","volume":"99","author":"Xu","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/pr.2013.137","article-title":"Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: Follow-up of a unique, moderately sized, randomized controlled trial","volume":"74","author":"Seggers","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib29","doi-asserted-by":"crossref","first-page":"e0150857","DOI":"10.1371\/journal.pone.0150857","article-title":"Does embryo culture medium influence the health and development of children born after in\u00a0vitro fertilization?","volume":"11","author":"Bouillon","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.earlhumdev.2009.10.003","article-title":"Growth and health outcome of 102 2-year-old children conceived after preimplantation genetic diagnosis or screening","volume":"85","author":"Desmyttere","year":"2009","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib31","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1093\/humrep\/dei504","article-title":"Paternal sperm concentration and growth and cognitive development in children born with a gestational age more than 32 weeks after assisted reproductive therapy","volume":"21","author":"Wennerholm","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib32","doi-asserted-by":"crossref","first-page":"e89713","DOI":"10.1371\/journal.pone.0089713","article-title":"Growth development of French children born after in\u00a0vitro maturation","volume":"9","author":"Foix-L\u2019Helias","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/humrep\/der375","article-title":"Are ICSI adolescents at risk for increased adiposity?","volume":"27","author":"Belva","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib34","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1093\/humrep\/des001","article-title":"Pubertal development in ICSI children","volume":"27","author":"Belva","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib35","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1210\/jc.2006-2896","article-title":"Body composition in children and adolescents born after in\u00a0vitro fertilization or spontaneous conception","volume":"92","author":"Ceelen","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib36","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1093\/humrep\/den309","article-title":"Pubertal development in children and adolescents born after IVF and spontaneous conception","volume":"23","author":"Ceelen","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib37","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1093\/humrep\/dep273","article-title":"Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8\u201318 years of IVF children and spontaneously conceived controls born to subfertile parents","volume":"24","author":"Ceelen","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib38","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1210\/jc.2006-2465","article-title":"In\u00a0vitro fertilization improves childhood growth and metabolism","volume":"92","author":"Miles","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib39","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/eci.12066","article-title":"Gender dimorphic increase in RBP-4 and NGAL in children born after IVF: an epigenetic phenomenon?","volume":"43","author":"Sakka","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib40","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1177\/2047487314535117","article-title":"Antioxidants improve vascular function in children conceived by assisted reproductive technologies: a randomized double-blind placebo-controlled trial","volume":"22","author":"Rimoldi","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib41","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.fertnstert.2009.12.023","article-title":"A cross-sectional evaluation of the first cohort of young adults conceived by in\u00a0vitro fertilization in the United States","volume":"94","author":"Beydoun","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib42","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.fertnstert.2010.04.057","article-title":"Pubertal development of the first cohort of young adults conceived by in\u00a0vitro fertilization in the United States","volume":"95","author":"Beydoun","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1472-6483(10)62116-5","article-title":"Medical follow-up study of 5-year-old ICSI children","volume":"9","author":"Bonduelle","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib44","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/humrep\/del372","article-title":"Medical outcome of 8-year-old singleton ICSI children (born \u226532 weeks\u2019 gestation) and a spontaneously conceived comparison group","volume":"22","author":"Belva","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib45","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2337\/db14-0103","article-title":"Altered glucose metabolism in mouse and humans conceived by IVF","volume":"63","author":"Chen","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib46","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/CIRCULATIONAHA.111.071183","article-title":"Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies","volume":"125","author":"Scherrer","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib47","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/humrep\/des259","article-title":"Blood pressure in ICSI-conceived adolescents","volume":"27","author":"Belva","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib48","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1210\/jc.2007-2432","article-title":"Cardiometabolic differences in children born after in\u00a0vitro fertilization: follow-up study","volume":"93","author":"Ceelen","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib49","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/humrep\/den402","article-title":"Two-year auxological and medical outcome of singletons born after embryo biopsy applied in preimplantation genetic diagnosis or preimplantation genetic screening","volume":"24","author":"Desmyttere","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib50","doi-asserted-by":"crossref","first-page":"e94001","DOI":"10.1371\/journal.pone.0094001","article-title":"Plasma metabolomic profiling suggests early indications for predisposition to latent insulin resistance in children conceived by ICSI","volume":"9","author":"Gkourogianni","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib51","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1016\/j.fertnstert.2013.02.009","article-title":"Phenotypic differences in children conceived from fresh and thawed embryos in in\u00a0vitro fertilization compared with naturally conceived children","volume":"99","author":"Green","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib52","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.fertnstert.2014.01.006","article-title":"Comparing indicators of health and development of singleton young adults conceived with and without assisted reproductive technology","volume":"101","author":"Halliday","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib53","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1210\/jc.2006-0701","article-title":"Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction","volume":"91","author":"Kai","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib54","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.fertnstert.2007.04.049","article-title":"Perinatal outcome, health, growth, and medical care utilization of 5- to 8-year-old intracytoplasmic sperm injection singletons","volume":"89","author":"Knoester","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib55","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapediatrics.2015.0214","article-title":"Association between assisted reproductive technology and cardiac alteration at age 5 years","volume":"169","author":"Liu","year":"2015","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fertnstert.2007.11.037","article-title":"Physical health at 5.5 years of age of term-born singletons after intracytoplasmic sperm injection: results of a prospective, controlled, single-blinded study","volume":"91","author":"Ludwig","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib57","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.rbmo.2014.11.006","article-title":"Subfertility and assisted reproduction techniques are associated with poorer cardiometabolic profiles in childhood","volume":"30","author":"Pontesilli","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib58","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.fertnstert.2009.09.049","article-title":"Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in\u00a0vitro fertilization","volume":"94","author":"Sakka","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib59","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/humrep\/det396","article-title":"Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part I: multivariable regression analysis","volume":"29","author":"Seggers","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib60","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1161\/CIRCULATIONAHA.113.002428","article-title":"Assisted reproductive technologies are associated with cardiovascular remodeling in utero that persists postnatally","volume":"128","author":"Valenzuela-Alcaraz","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib61","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1152\/japplphysiol.00533.2014","article-title":"Right ventricular dysfunction in children and adolescents conceived by assisted reproductive technologies","volume":"118","author":"Von Arx","year":"2015","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib62","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1159\/000366315","article-title":"Association of cardiac development with assisted reproductive technology in childhood: a prospective single-blind pilot study","volume":"34","author":"Zhou","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib63","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib64","series-title":"Introduction to meta-analysis","author":"Borenstein","year":"2009"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib65","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1006\/pmed.1998.0376","article-title":"Distributions and trends of serum lipid levels among United States children and adolescents ages 4\u201319 years: data from the Third National Health and Nutrition Examination Survey","volume":"27","author":"Hickman","year":"1998","journal-title":"Prev Med"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib66","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1542\/peds.114.S2.555","article-title":"The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib67","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2147\/tcrm.2006.2.4.355","article-title":"In\u00a0vitro fertilization (IVF): a review of 3 decades of clinical innovation and technological advancement","volume":"2","author":"Wang","year":"2006","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib68","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jama.2014.17985","article-title":"Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection","volume":"313","author":"Boulet","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/bmj.306.6869.24","article-title":"Initiation of hypertension in utero and its amplification throughout life","volume":"306","author":"Law","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.HYP.0000226410.11198.f4","article-title":"Changes in metabolic syndrome variables since childhood in prehypertensive and hypertensive subjects: the Bogalusa Heart Study","volume":"48","author":"Srinivasan","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib71","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1161\/CIRCULATIONAHA.107.730366","article-title":"Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis","volume":"117","author":"Chen","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib72","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1097\/HJH.0b013e32832e8cfa","article-title":"Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults","volume":"27","author":"Rademacher","year":"2009","journal-title":"J Hypertens"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib73","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.metabol.2011.08.010","article-title":"Childhood risk factors predict cardiovascular disease, impaired fasting glucose plus type 2 diabetes mellitus, and high blood pressure 26 years later at a mean age of 38 years: the Princeton-lipid research clinics follow-up study","volume":"61","author":"Morrison","year":"2012","journal-title":"Metabolism"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib74","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1001\/jama.288.15.1882","article-title":"Primary prevention of hypertension: clinical and public health advisory from the National High Blood Pressure Education Program","volume":"288","author":"Whelton","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib75","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archinte.1995.00430070053006","article-title":"Implications of small reductions in diastolic blood pressure for primary prevention","volume":"155","author":"Cook","year":"1995","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib76","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/humrep\/deq003","article-title":"Trends in delivery and neonatal outcome after in\u00a0vitro fertilization in Sweden: data for 25 years","volume":"25","author":"Kallen","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib77","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/AOG.0b013e318269c282","article-title":"Assisted reproductive technology and major birth defects in Western Australia","volume":"120","author":"Hansen","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib78","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/humrep\/deu345","article-title":"Trends in perinatal health after assisted reproduction: a Nordic study from the CoNARTaS group","volume":"30","author":"Henningsen","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib79","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/humupd\/dms062","article-title":"The longer-term health outcomes for children born as a result of IVF treatment: Part I\u2014general health outcomes","volume":"19","author":"Hart","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib80","series-title":"Gamete and embryo-fetal origins of adult diseases","first-page":"197","article-title":"Assisted reproductive technology and gamete\/embryo-fetal origins of diseases","author":"Zhu","year":"2014"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib81","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1152\/physrev.00029.2013","article-title":"Early developmental conditioning of later health and disease: physiology or pathophysiology?","volume":"94","author":"Hanson","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib82","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/hmg\/ddm187","article-title":"Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients","volume":"16","author":"Kobayashi","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib83","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/jmg.2008.057943","article-title":"Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes","volume":"45","author":"Khoueiry","year":"2008","journal-title":"J Med Genet"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib84","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/ars.2010.3186","article-title":"Redox regulation of human sperm function: from the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line","volume":"14","author":"Aitken","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib85","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0015-0282(99)00549-X","article-title":"Clomiphene citrate-induced perturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes in\u00a0vivo and in\u00a0vitro","volume":"73","author":"London","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib86","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/humrep\/dei283","article-title":"Meiotic abnormalities in in\u00a0vitro-matured marmoset monkey (Callithrix jacchus) oocytes: development of a non-human primate model to investigate causal factors","volume":"21","author":"Delimitreva","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib87","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.fertnstert.2007.06.004","article-title":"Assisted reproductive technology may increase clinical mutation detection in male offspring","volume":"90","author":"Feng","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib88","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1093\/hmg\/ddp319","article-title":"DNA methylation and gene expression differences in children conceived in\u00a0vitro or in\u00a0vivo","volume":"18","author":"Katari","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib89","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/humupd\/dmr047","article-title":"Assisted reproduction treatment and epigenetic inheritance","volume":"18","author":"Van Montfoort","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib90","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1210\/jc.2008-0574","article-title":"CCAAT\/enhancer binding protein alpha (C\/EBP\u03b1) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C\/EBP\u03b1 is associated with serum levels of triglycerides","volume":"93","author":"Olofsson","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib91","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.fertnstert.2011.09.033","article-title":"General imprinting status is stable in assisted reproduction-conceived offspring","volume":"96","author":"Feng","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib92","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/humrep\/deu094","article-title":"Epigenetic status in the offspring of spontaneous and assisted conception","volume":"29","author":"Whitelaw","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib93","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.fertnstert.2016.04.036","article-title":"Altered DNA methylation and expression of PLAGL1 in cord blood from assisted reproductive technology pregnancies compared with natural conceptions","volume":"106","author":"Vincent","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib94","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1093\/hmg\/dds287","article-title":"Gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice","volume":"21","author":"de Waal","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib95","doi-asserted-by":"crossref","first-page":"10086","DOI":"10.1038\/srep10086","article-title":"High maternal serum estradiol levels induce dyslipidemia in human newborns via a hepatic HMGCR estrogen response element","volume":"5","author":"Meng","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib96","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.earlhumdev.2006.07.001","article-title":"The Dutch famine and its long-term consequences for adult health","volume":"82","author":"Roseboom","year":"2006","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib97","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1017\/S0007114509993783","article-title":"Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring","volume":"103","author":"Watkins","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib98","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mnfr.201200084","article-title":"Influence of maternal folate status on human fetal growth parameters","volume":"57","author":"van Uitert","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib99","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"7","author":"Weaver","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4161\/epi.3.2.6034","article-title":"Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses","volume":"3","author":"Oberlander","year":"2008","journal-title":"Epigenetics"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib101","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00023.2015","article-title":"Physiological aspects of female fertility: role of the environment, modern lifestyle, and genetics","volume":"96","author":"Hart","year":"2016","journal-title":"Physiol Rev"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib102","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/eurheartj\/ehv207","volume":"36","author":"Arena","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib103","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S1472-6483(10)60599-8","article-title":"Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study","volume":"16","author":"Banerjee","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib104","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/humupd\/dmv001","article-title":"Artificial gametes: a systematic review of biological progress towards clinical application","volume":"21","author":"Hendriks","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2016.12.007_bib105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Hum Reprod Update"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216630753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216630753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T02:48:51Z","timestamp":1666493331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028216630753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":105,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0015028216630753"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2016.12.007","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2016.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92016 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}