{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:25Z","timestamp":1791910765596,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":1426,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.fertnstert.2018.03.017","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T08:02:02Z","timestamp":1528876922000},"page":"103-112.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":210,"title":["Effects of chronic endometritis therapy on in\u00a0vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-5435","authenticated-orcid":false,"given":"Amerigo","family":"Vitagliano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Saccardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Noventa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Di Spiezio Sardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Saccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Cicinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Andrisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Salvatore","family":"Litta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2018.03.017_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/aji.12438","article-title":"Chronic endometritis: potential cause of infertility and obstetric and neonatal complications","volume":"75","author":"Kitaya","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.rbmo.2017.09.008","article-title":"Prevalence and confounders of chronic endometritis in premenopausal women with abnormal bleeding or reproductive failure","volume":"36","author":"Song","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/0974-2727.105584","article-title":"Evaluation of endometrium for chronic endometritis by using syndecan-1 in abnormal uterine bleeding","volume":"4","author":"Kannar","year":"2012","journal-title":"J Lab Physicians"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5653\/cerm.2016.43.4.185","article-title":"Chronic endometritis and infertility","volume":"43","author":"Park","year":"2016","journal-title":"Clin Exp Reprod Med"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/aji.12508","article-title":"Systemic inflammation and autoimmunity in women with chronic endometritis","volume":"75","author":"Kushnir","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12782","article-title":"Chronic endometritis in patients with unexplained infertility: prevalence and effects of antibiotic treatment on spontaneous conception","volume":"79","author":"Cicinelli","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12758","article-title":"Chronic endometritis: really so relevant in repeated IVF failure?","volume":"78","author":"Vitagliano","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.fertnstert.2011.09.039","article-title":"The impact of chronic endometritis on reproductive outcome","volume":"96","author":"Kasius","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int J Surg"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib10","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib11","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/modpathol.3880405","article-title":"Plasma cells in chronic endometritis are easily identified when stained with syndecan-1","volume":"14","author":"Bayer-Garner","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.fertnstert.2004.01.054","article-title":"Impact of detection of bacterial endotoxin in menstrual effluent on the pregnancy rate in in\u00a0vitro fertilization and embryo transfer","volume":"82","author":"Kamiyama","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib13","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.fertnstert.2007.03.074","article-title":"Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies","volume":"89","author":"Cicinelli","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000223819","article-title":"Poor reliability of vaginal and endocervical cultures for evaluating microbiology of endometrial cavity in women with chronic endometritis","volume":"68","author":"Cicinelli","year":"2009","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib15","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.fertnstert.2009.12.083","article-title":"Reliability of narrow-band imaging (NBI) hysteroscopy: a comparative study","volume":"94","author":"Cicinelli","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib16","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.fertnstert.2010.09.061","article-title":"Prevalence of chronic endometritis in recurrent miscarriages","volume":"95","author":"Kitaya","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1477-7827-11-37","article-title":"Successful implantation after reducing matrix metalloproteinase activity in the uterine cavity","volume":"11","author":"Yoshii","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1177\/1933719113508817","article-title":"Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment","volume":"21","author":"Cicinelli","year":"2014","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.12891\/ceog16562014","article-title":"The role of hysteroscopy in the diagnostic work-up of infertile asymptomatic patients","volume":"41","author":"Indraccolo","year":"2014","journal-title":"Clin Exp Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.fertnstert.2013.12.031","article-title":"Chronic endometritis in women with recurrent early pregnancy loss and\/or fetal demise","volume":"101","author":"McQueen","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib21","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.fertnstert.2015.06.044","article-title":"Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss","volume":"104","author":"McQueen","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.fertnstert.2008.12.131","article-title":"Chronic endometritis is a frequent finding in women with recurrent implantation failure after in\u00a0vitro fertilization","volume":"93","author":"Johnston-MacAnanny","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib23","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00404-013-3131-2","article-title":"The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients","volume":"289","author":"Yang","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humrep\/deu292","article-title":"Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy","volume":"30","author":"Cicinelli","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5935\/1518-0557.20150012","article-title":"Repeated implantation failure in oocyte donation. What to do to improve the endometrial receptivity?","volume":"19","author":"Tersoglio","year":"2015","journal-title":"JBRA Assist Reprod"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12719","article-title":"Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure","volume":"78","author":"Kitaya","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3109\/00016349.2010.498496","article-title":"Correspondence between hysteroscopic and histologic findings in women with chronic endometritis","volume":"89","author":"Cicinelli","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/1933719115594020","article-title":"Serum stem cell factor assay in elderly poor responder patients undergoing IVF: a new biomarker to customize follicle aspiration cycle by cycle","volume":"23","author":"Gizzo","year":"2016","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/aji.12430","article-title":"Reduced circulating concentration of brain-derived neurotrophic factor is associated with peri- and post-implantation failure following in\u00a0vitro fertilization-embryo transfer","volume":"75","author":"Ramer","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.fertnstert.2017.08.023","article-title":"Introduction: contemporary approaches to alternative ovarian stimulation strategies for in\u00a0vitro fertilization","volume":"108","author":"Paulson","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12766","article-title":"Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure","volume":"78","author":"Zhang","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13048-016-0284-1","article-title":"Salpingectomy before assisted reproductive technologies: a systematic literature review","volume":"9","author":"Noventa","year":"2016","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00404-015-3792-0","article-title":"Surgery, endometriosis-related infertility and negative impact on ovarian reserve: \u201cwhich came first, the hen or the egg?\u201d An unresolved dilemma","volume":"292","author":"Gizzo","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib34","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/aji.12591","article-title":"Implantation: cell biology of embryo penetration route revisited","volume":"76","author":"Denker","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12597","article-title":"Autoimmunity, systemic inflammation, and their correlation with repeated implantation failure and recurrent miscarriage: is chronic endometritis the missing piece of the jigsaw?","volume":"77","author":"Vitagliano","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1189\/jlb.0708395","article-title":"Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment","volume":"85","author":"van Mourik","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.fertnstert.2017.09.021","article-title":"Endometrial scratch injury before intrauterine insemination: is it time to re-evaluate its value? Evidence from a systematic review and meta-analysis of randomized controlled trials","volume":"109","author":"Vitagliano","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib38","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1096\/fj.05-3781hyp","article-title":"Embryonic implantation and leukocyte transendothelial migration: different processes with similar players?","volume":"19","author":"Dominguez","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12958-017-0233-x","article-title":"Chronic endometritis modifies decidualization in human endometrial stromal cells","volume":"15","author":"Wu","year":"2017","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib40","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1600-0897.2009.00698.x","article-title":"Abnormal pattern of lymphocyte subpopulations in the endometrium of infertile women with chronic endometritis","volume":"61","author":"Matteo","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/aji.12277","article-title":"Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis","volume":"72","author":"Kitaya","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2018.03.017_bib42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/aji.12076","article-title":"Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endometritis","volume":"69","author":"Di Pietro","year":"2013","journal-title":"Am J Reprod Immunol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502821830270X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502821830270X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T16:52:58Z","timestamp":1767113578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001502821830270X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S001502821830270X"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2018.03.017","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of chronic endometritis therapy on in\u00a0vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2018.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92018 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}