{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:11:50Z","timestamp":1790349110691,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":1152,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.fertnstert.2018.11.047","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T17:46:52Z","timestamp":1553881612000},"page":"722-733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Corifollitropin alfa for ovarian stimulation in in\u00a0vitro fertilization: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-2357","authenticated-orcid":false,"given":"Mauro","family":"Cozzolino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amerigo","family":"Vitagliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-3353","authenticated-orcid":false,"given":"Gustavo Nardini","family":"Cecchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ambrosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Garcia-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2018.11.047_bib1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/oxfordjournals.humrep.a019276","article-title":"Impact of the in-vitro fertilization process on emotional, physical and relational variables","volume":"11","author":"Boivin","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib2","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/humrep\/den219","article-title":"Why do couples drop-out from IVF treatment? A prospective cohort study","volume":"23","author":"Verberg","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.rbmo.2012.11.015","article-title":"Evaluation of the degree of satisfaction in oocyte donors using sustained-release FSH corifollitropin alpha","volume":"26","author":"Requena","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/1518-0557.20160001","article-title":"Often times, we should look at IVF more simply","volume":"20","author":"de Carvalho","year":"2016","journal-title":"JBRA Assist Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib5","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1093\/humrep\/dep291","article-title":"A double-blind, non-inferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH antagonist protocol","volume":"24","author":"Devroey","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.rbmo.2011.04.002","article-title":"Corifollitropin alfa doses based on body weight: clinical overview of drug exposure and ovarian response","volume":"23","author":"Ledger","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmn065","article-title":"Advances in recombinant DNA technology: corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequency","volume":"15","author":"Fauser","year":"2009","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib8","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S1472-6483(10)60141-1","article-title":"Effect of cetrorelix dose on premature LH surge during ovarian stimulation","volume":"16","author":"Lin","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib9","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/humrep\/deu301","article-title":"Corifollitropin alfa compared with follitropin beta in poor responders undergoing ICSI: a randomized controlled trial","volume":"30","author":"Kolibianakis","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib11","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/humrep\/dex296","article-title":"Corifollitropin alfa followed by highly purified HMG versus recombinant FSH in young poor ovarian responders: a multicentre randomized controlled clinical trial","volume":"32","author":"Drakopoulos","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib12","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1210\/jc.2003-031766","article-title":"Induction of multiple follicular development by a single dose of long-acting recombinant follicle-stimulating hormone (FSH-CTP, corifollitropin alfa) for controlled ovarian stimulation before in\u00a0vitro fertilization","volume":"89","author":"Devroey","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.rbmo.2010.03.019","article-title":"Corifollitropin alfa for ovarian stimulation in IVF: a randomized trial in lower-body-weight women","volume":"21","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib14","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1093\/humrep\/den288","article-title":"A randomized dose-response trial of a single injection of corifollitropin alfa to sustain multifollicular growth during controlled ovarian stimulation","volume":"23","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.fertnstert.2015.04.018","volume":"104","author":"Boostanfar","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib16","first-page":"11","article-title":"Corifollitropin alfa vs recombinant FSH for controlled ovarian stimulation in women aged 35\u201342 years with a body weight \u226550 kg: a randomized controlled trial","volume":"1","author":"Vuong","year":"2017","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.fertnstert.2012.09.043","article-title":"Corifollitropin alfa followed by rFSH in a GnRH antagonist protocol for poor ovarian responder patients: an observational pilot study","volume":"99","author":"Polyzos","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0015-0282(01)01931-8","article-title":"Stress and marital satisfaction among women before and after their first cycle of in\u00a0vitro fertilization and intracytoplasmic sperm injection","volume":"76","author":"Verhaak","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.fertnstert.2003.06.029","article-title":"Why do couples discontinue in\u00a0vitro fertilization treatment? A cohort study","volume":"81","author":"Olivius","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib20","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/humrep\/16.7.1391","article-title":"Friendly IVF: patient opinions","volume":"16","author":"Hojgaard","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.rbms.2018.01.001","article-title":"Comparative economic study of the use of corifollitropin alfa and daily rFSH for controlled ovarian stimulation in older patients: cost-minimization analysis based on the PURSUE study","volume":"5","author":"Barrenetxea","year":"2018","journal-title":"Reprod Biomed Soc Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1472-6483(10)60654-2","article-title":"Impact of duration and dose of gonadotrophins on IVF outcomes","volume":"13","author":"Martin","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.rbmo.2017.03.003","article-title":"Economic impact of ovarian stimulation with corifollitropin alfa versus conventional daily gonadotropins in oocyte donors: a randomized study","volume":"34","author":"Cruz","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib24","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.fertnstert.2012.01.092","article-title":"Is there a place for corifollitropin alfa in IVF\/ICSI cycles? A systematic review and meta-analysis","volume":"97","author":"Mahmoud Youssef","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13048-015-0160-4","article-title":"Corifollitropin alfa compared to daily FSH in controlled ovarian stimulation for in\u00a0vitro fertilization: a meta-analysis","volume":"8","author":"Fensore","year":"2015","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.rbmo.2016.04.005","article-title":"Corifollitropin alfa versus recombinant follicle-stimulating hormone: an individual patient data meta-analysis","volume":"33","author":"Griesinger","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib27","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1016\/j.fertnstert.2012.02.047","article-title":"Comment on, \u201cIs there a place for corifollitropin alfa in IVF\/ICSI cycles? A systematic review and meta-analysis.\u201d","volume":"97","author":"Mannaerts","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2018.11.047_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejogrb.2018.10.034","article-title":"Ovarian stimulation with corifollitropin alfa followed by hp-hMG compared to hp-hMG in patients at risk of poor ovarian response undergoing ICSI: a randomized controlled trial","volume":"231","author":"Taronger","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"updated-by":[{"DOI":"10.1016\/j.fertnstert.2020.10.043","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000}}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028218322489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028218322489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:50:03Z","timestamp":1765410603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028218322489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0015028218322489"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2018.11.047","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corifollitropin alfa for ovarian stimulation in in\u00a0vitro fertilization: a systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2018.11.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92018 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}