{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:33:51Z","timestamp":1790336031458,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":1091,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.fertnstert.2019.05.006","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T03:57:04Z","timestamp":1559188624000},"page":"1047-1053","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Impact of male factor infertility on offspring health and development"],"prefix":"10.1016","volume":"111","author":[{"given":"Alice R.","family":"Rumbold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arusyak","family":"Sevoyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassia K.","family":"Oswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renae C.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2019.05.006_bib1","series-title":"WHO manual for the standardized investigation and diagnosis of the infertile male","author":"Rowe","year":"2000"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1136\/bmj.291.6510.1693","article-title":"Population study of causes, treatment, and outcome of infertility","volume":"291","author":"Hull","year":"1985","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/oxfordjournals.humrep.a137433","article-title":"Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989)","volume":"6","author":"Thonneau","year":"1991","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib4","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/j.fertnstert.2008.03.022","article-title":"Infertility services reported by men in the United States: national survey data","volume":"91","author":"Anderson","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib5","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.21037\/tau.2018.05.03","article-title":"Gaps in male infertility health services research","volume":"7","author":"Leung","year":"2018","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib7","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.fertnstert.2014.12.103","article-title":"Diagnostic evaluation of the infertile male: a committee opinion","volume":"103","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1472-6483(10)60911-X","article-title":"Y chromosome assessment and its implications for the development of ICSI children","volume":"8","author":"Katagiri","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/jc.2004-1469","article-title":"Genetic Abnormalities among Severely Oligospermic Men Who Are Candidates for Intracytoplasmic Sperm Injection","volume":"90","author":"Foresta","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/cge.12905","article-title":"Genetic abnormalities leading to qualitative defects of sperm morphology or function","volume":"91","author":"Ray","year":"2017","journal-title":"Clin Genet"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib11","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/humrep\/17.11.2783","article-title":"Epigenetic risks related to assisted reproductive technologies: short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?","volume":"17","author":"Thompson","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1017\/S2040174417000228","article-title":"The health outcomes of human offspring conceived by assisted reproductive technologies (ART)","volume":"8","author":"Chen","year":"2017","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib13","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/humrep\/deu094","article-title":"Epigenetic status in the offspring of spontaneous and assisted conception","volume":"29","author":"Whitelaw","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib14","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/humrep\/dex085","article-title":"The impact of specific fertility treatments on cognitive development in childhood and adolescence: a systematic review","volume":"32","author":"Rumbold","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/andr.12369","article-title":"Long-term follow-up of intra-cytoplasmic sperm injection-conceived offspring compared with in\u00a0vitro fertilization-conceived offspring: a systematic review of health outcomes beyond the neonatal period","volume":"5","author":"Catford","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/andr.12526","article-title":"Long-term follow-up of ICSI-conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period","volume":"6","author":"Catford","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/1471-0528.15456","article-title":"Childhood growth of singletons conceived following in\u00a0vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis","volume":"126","author":"Bay","year":"2019","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jama.2014.17985","article-title":"Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection","volume":"313","author":"Boulet","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib19","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/humrep\/dew092","article-title":"Santa Claus in the fertility clinic","volume":"31","author":"Evers","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib20","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/S0140-6736(00)05180-1","article-title":"Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study","volume":"357","author":"Sutcliffe","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0015-0282(02)04701-5","article-title":"A retrospective case-control study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom","volume":"79","author":"Sutcliffe","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib22","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/humrep\/deg061","article-title":"Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF","volume":"18","author":"Bonduelle","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib23","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1093\/humrep\/deg408","article-title":"Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age","volume":"18","author":"Leslie","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib24","first-page":"1514","article-title":"Paternal sperm concentration and growth and cognitive development in children born with a gestational age more than 32 weeks after assisted reproductive","volume":"21","author":"Wennerholm","year":"2006","journal-title":"therapy"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib25","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/humrep\/der136","article-title":"Follow-up of children born after ICSI with epididymal spermatozoa","volume":"26","author":"Woldringh","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib26","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S1472-6483(10)60411-7","article-title":"Genetic and epigenetic characteristics of ICSI children","volume":"17","author":"Palermo","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/jama.2013.7222","article-title":"Autism and mental retardation among offspring born after in\u00a0vitro fertilization","volume":"310","author":"Sandin","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib28","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/humrep\/deu338","article-title":"Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children","volume":"30","author":"Kissin","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib29","doi-asserted-by":"crossref","first-page":"f3978","DOI":"10.1136\/bmj.f3978","article-title":"Fertility treatment and risk of childhood and adolescent mental disorders: register based cohort study","volume":"347","author":"Bay","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/jech.2009.093823","article-title":"Risk of autism spectrum disorders in children born after assisted conception: a population-based follow-up study","volume":"65","author":"Hvidtjorn","year":"2011","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/archpediatrics.2008.507","article-title":"Cerebral palsy, autism spectrum disorders, and developmental delay in children born after assisted conception: a systematic review and meta-analysis","volume":"163","author":"Hvidtjorn","year":"2009","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1542\/peds.2005-2585","article-title":"Cerebral palsy among children born after in\u00a0vitro fertilization: the role of preterm delivery\u2013a population-based, cohort study","volume":"118","author":"Hvidtjorn","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib34","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/humupd\/dmu032","article-title":"Comparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding","volume":"20","author":"Bloise","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib35","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1073\/pnas.0806560105","article-title":"Persistent epigenetic differences associated with prenatal exposure to famine in humans","volume":"105","author":"Heijmans","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/8170518","article-title":"Metabolic syndrome and its components in young adults conceived by ICSI","volume":"2018","author":"Belva","year":"2018","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/humrep\/del372","article-title":"Medical outcome of 8-year-old singleton ICSI children (born >or=32 weeks' gestation) and a spontaneously conceived comparison group","volume":"22","author":"Belva","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib38","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/humrep\/des259","article-title":"Blood pressure in ICSI-conceived adolescents","volume":"27","author":"Belva","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/humrep\/der375","article-title":"Are ICSI adolescents at risk for increased adiposity?","volume":"27","author":"Belva","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib40","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.fertnstert.2016.09.009","article-title":"Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births","volume":"106","author":"Kettner","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib41","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1210\/jc.2007-0095","article-title":"Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection","volume":"92","author":"Mau Kai","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib42","first-page":"359","article-title":"Testicular growth and tubular function in prepubertal boys conceived by intracytoplasmic sperm injection","volume":"71","author":"De Schepper","year":"2009","journal-title":"Horm Res"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib43","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/humrep\/deq249","article-title":"Serum inhibin B concentrations in pubertal boys conceived by ICSI: first results","volume":"25","author":"Belva","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib44","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/humrep\/deq345","article-title":"Salivary testosterone concentrations in pubertal ICSI boys compared with spontaneously conceived boys","volume":"26","author":"Belva","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib45","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/humrep\/dew245","article-title":"Semen quality of young adult ICSI offspring: the first results","volume":"31","author":"Belva","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib46","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/humrep\/dew324","article-title":"Reproductive hormones of ICSI-conceived young adult men: the first results","volume":"32","author":"Belva","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.05.006_bib47","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/humupd\/dmx021","article-title":"The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance\u2014challenges and future research opportunities","volume":"23","author":"Barratt","year":"2017","journal-title":"Hum Reprod Update"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219304303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219304303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:22:33Z","timestamp":1758010953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028219304303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0015028219304303"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.05.006","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of male factor infertility on offspring health and development","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92019 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}