{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:56:35Z","timestamp":1768917395599,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":877,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002603","name":"American Society for Reproductive Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015340","name":"Bayer Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.fertnstert.2019.08.090","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T16:37:24Z","timestamp":1580834244000},"page":"176-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma"],"prefix":"10.1016","volume":"113","author":[{"given":"Toral P.","family":"Parikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-6575","authenticated-orcid":false,"given":"Minnie","family":"Malik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Britten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine M.","family":"Aly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Pilgrim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Catherino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2019.08.090_bib1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"124","author":"Stewart","year":"2017","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0037-1599090","article-title":"Recent advances in uterine fibroid etiology","volume":"35","author":"McWilliams","year":"2017","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humupd\/dmu048","article-title":"Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications","volume":"21","author":"Moravek","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib4","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.fertnstert.2014.01.017","article-title":"Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth","volume":"101","author":"Ono","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib5","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/humrep\/dev069","article-title":"Use of depot medroxyprogesterone acetate and prevalent leiomyoma in young African American women","volume":"30","author":"Harmon","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00441-010-0956-x","article-title":"Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen","volume":"340","author":"Richeri","year":"2010","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2014.11.009","article-title":"Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity","volume":"187","author":"Monica Brauer","year":"2015","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/1389203717666160322145411","article-title":"Plasticity in uterine innervation: state of the art","volume":"18","author":"Brauer","year":"2017","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/BF00226501","article-title":"Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus. Retrograde tracing and immunocytochemistry, effects of chemical sympathectomy, capsaicin treatment and pregnancy","volume":"254","author":"Alm","year":"1988","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib10","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1523\/JNEUROSCI.1704-12.2013","article-title":"Bone morphogenetic protein 4 mediates estrogen-regulated sensory axon plasticity in the adult female reproductive tract","volume":"33","author":"Bhattacherjee","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/(SICI)1096-9861(19980810)397:4<561::AID-CNE8>3.0.CO;2-#","article-title":"Variations in uterine innervation during the estrous cycle in rat","volume":"397","author":"Zoubina","year":"1998","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib12","first-page":"989","article-title":"Acute and chronic estrogen supplementation decreases uterine sympathetic innervation in ovariectomized adult virgin rats","volume":"16","author":"Zoubina","year":"2001","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib13","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1523\/JNEUROSCI.15-03-02141.1995","article-title":"Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules","volume":"15","author":"Struyk","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1083\/jcb.117.3.617","article-title":"Expression of unique sets of GPI-linked proteins by different primary neurons in\u00a0vitro","volume":"117","author":"Rosen","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib15","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1523\/JNEUROSCI.18-22-09312.1998","article-title":"Neurotrimin mediates bifunctional effects on neurite outgrowth via homophilic and heterophilic interactions","volume":"18","author":"Gil","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib16","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1023\/A:1020673318536","article-title":"Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis","volume":"30","author":"Chen","year":"2001","journal-title":"J Neurocytol"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/sj.sc.3101842","article-title":"Expression of neurotrimin in the normal and injured adult human spinal cord","volume":"44","author":"Grijalva","year":"2006","journal-title":"Spinal Cord"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib18","first-page":"193","article-title":"GPI-anchored proteins in neural cell adhesion","volume":"Vol. 16","author":"Salzer","year":"1996"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib19","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1006\/mcne.2001.0964","article-title":"Identification and characterization of CEPU-Se\u2014a secreted isoform of the IgLON family protein, CEPU-1","volume":"17","author":"Lodge","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbr.2016.09.064","article-title":"Deficit in emotional learning in neurotrimin knockout mice","volume":"317","author":"Mazitov","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/neu.10050","article-title":"Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP","volume":"51","author":"Gil","year":"2002","journal-title":"J Neurobiol"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib22","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1360\/03yc0072","article-title":"The cloning and preliminarily functional analysis of the human neurotrimin gene","volume":"47","author":"Liu","year":"2004","journal-title":"Sci China C Life Sci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib23","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1002\/jnr.21768","article-title":"Neurotrimin is an estrogen-regulated determinant of peripheral sympathetic innervation","volume":"86","author":"Krizsan-Agbas","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/humupd\/dmh019","article-title":"Sex steroidal regulation of uterine leiomyoma growth and apoptosis","volume":"10","author":"Maruo","year":"2004","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1749-6632.2001.tb03992.x","article-title":"Estrogen-associated genes in uterine leiomyoma","volume":"948","author":"Li","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib26","first-page":"4092","article-title":"Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment","volume":"83","author":"Englund","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib27","doi-asserted-by":"crossref","first-page":"e79838","DOI":"10.1371\/journal.pone.0079838","article-title":"Measurement of phenolic environmental estrogens in women with uterine leiomyoma","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/AOG.0b013e3181705d0e","article-title":"CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial","volume":"111","author":"Levens","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2265.2008.03207.x","article-title":"Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells","volume":"69","author":"Malik","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib30","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.fertnstert.2006.08.111","article-title":"Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays","volume":"87","author":"Malik","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib31","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.fertnstert.2008.06.030","article-title":"Activating transcription factor 3 gene expression suggests that tissue stress plays a role in leiomyoma development","volume":"92","author":"Payson","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/1933719117728802","article-title":"Ulipristal acetate and extracellular matrix production in human leiomyomas in\u00a0vivo: a laboratory analysis of a randomized placebo controlled trial","volume":"25","author":"Cox","year":"2018","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.50.10.801","article-title":"European Organization for Research and Treatment of Cancer\u2013Gynaecological Cancer Cooperative Group. A scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG","volume":"50","author":"van Diest","year":"1997","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib34","first-page":"603","article-title":"[Research on the relationship between estrogen receptor, progesterone receptor, cell proliferation associated antigen in uterine leiomyoma and nuclear body density of myoma, serum reproductive hormone concentrations]","volume":"30","author":"Wu","year":"1995","journal-title":"Zhonghua fu chan ke za zhi"},{"issue":"Suppl 1","key":"10.1016\/j.fertnstert.2019.08.090_bib35","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/S0140-6736(15)60341-5","article-title":"Identification of novel biomarkers in plasma for prediction of treatment response in patients with heart failure","volume":"385","author":"Cao","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2019.08.090_bib36","doi-asserted-by":"crossref","first-page":"10356","DOI":"10.1093\/nar\/gks750","article-title":"MiR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury","volume":"40","author":"Yu","year":"2012","journal-title":"Nucleic Acids Res"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219323015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219323015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:14:52Z","timestamp":1762150492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028219323015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0015028219323015"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.08.090","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.08.090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92019 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine","name":"copyright","label":"Copyright"}]}}