{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:20:10Z","timestamp":1782541210531,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":817,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771645"],"award-info":[{"award-number":["81771645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971447"],"award-info":[{"award-number":["81971447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.fertnstert.2019.10.029","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T08:13:17Z","timestamp":1582618397000},"page":"561-568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["A homozygous RPL10L missense mutation associated with male\u00a0factor\u00a0infertility and severe oligozoospermia"],"prefix":"10.1016","volume":"113","author":[{"given":"Chaofeng","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchuan","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Qiu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2019.10.029_bib1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0140-6736(96)08341-9","article-title":"Male infertility","volume":"349","author":"de Kretser","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1055\/s-0033-1345273","article-title":"Risks of reproducing with a genetic disorder","volume":"31","author":"Byler","year":"2013","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/humupd\/dmv020","article-title":"Teratozoospermia: spotlight on the main genetic actors in the human","volume":"21","author":"Coutton","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib6","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1749-6632.2010.05917.x","article-title":"Mendelian genetics of male infertility","volume":"1214","author":"Hwang","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s40618-014-0053-1","article-title":"Relevance of genetic investigation in male infertility","volume":"37","author":"Asero","year":"2014","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib8","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1073\/pnas.1635054100","article-title":"A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets","volume":"100","author":"Schultz","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib9","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nm.f.1895","article-title":"The biology of infertility: research advances and clinical challenges","volume":"14","author":"Matzuk","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib10","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/gim.2016.225","article-title":"A familial study of azoospermic men identifies three novel causative mutations in three new human azoospermia genes","volume":"19","author":"Gershoni","year":"2017","journal-title":"Genet Med"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/jmedgenet-2013-102102","article-title":"Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia","volume":"51","author":"Ayhan","year":"2014","journal-title":"J Med Genet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib12","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1056\/NEJMoa1406192","article-title":"X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men","volume":"372","author":"Yatsenko","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib13","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1093\/hmg\/ddv290","article-title":"Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family","volume":"24","author":"Okutman","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib14","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/humrep\/dez016","article-title":"A\u00a0new MEIOB mutation is a recurrent cause for azoospermia and testicular meiotic arrest","volume":"34","author":"Gershoni","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib15","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0140-6736(03)14845-3","article-title":"Azoospermia in patients heterozygous for a mutation in SYCP3","volume":"362","author":"Miyamoto","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib16","doi-asserted-by":"crossref","first-page":"e1003645","DOI":"10.1371\/journal.pgen.1003645","article-title":"The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans","volume":"9","author":"Wang","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11427-016-0274-9","article-title":"Association analysis between HFM1 variations and idiopathic azoospermia or severe oligozoospermia in Chinese Men","volume":"60","author":"Zhang","year":"2017","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib18","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1093\/humrep\/dey073","article-title":"A MEI1 homozygous missense mutation associated with meiotic arrest in a consanguineous family","volume":"33","author":"Ben Khelifa","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib19","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/gim.2017.130","article-title":"Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans","volume":"21","author":"Tan","year":"2019","journal-title":"Genet Med"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/cge.13475","article-title":"XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans","volume":"95","author":"Zhang","year":"2019","journal-title":"Clin Genet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/jmedgenet-2017-104992","article-title":"DMC1 mutation that\u00a0causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing","volume":"55","author":"He","year":"2018","journal-title":"J Med Genet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib22","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.cub.2017.04.017","article-title":"RPL10L is required for male meiotic division by compensating for RPL10 during meiotic sex chromosome inactivation in mice","volume":"27","author":"Jiang","year":"2017","journal-title":"Curr Biol"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41436-018-0064-y","article-title":"ZP2 pathogenic variants cause in\u00a0vitro fertilization failure and female infertility","volume":"21","author":"Dai","year":"2019","journal-title":"Genet Med"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib24","first-page":"103","article-title":"A complement for the WHO laboratory manual for the examination and processing of human semen. 1st ed","volume":"23","author":"Sanchez-Alvarez","year":"2012","journal-title":"EJIFCC"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib25","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1136\/jmedgenet-2019-106031","article-title":"Biallelic mutations in CFAP65 lead to severe asthenoteratospermia due to acrosome hypoplasia and flagellum malformations","volume":"56","author":"Wang","year":"2019","journal-title":"J Med Genet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib26","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1021\/pr9008964","article-title":"Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like","volume":"9","author":"Sugihara","year":"2010","journal-title":"J Proteome Res"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1126\/science.1090042","article-title":"Extensive gene traffic on the mammalian X chromosome","volume":"303","author":"Emerson","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tem.2004.01.007","article-title":"X chromosomes, retrogenes and their role in male reproduction","volume":"15","author":"Wang","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib29","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1093\/molbev\/msm153","article-title":"Origins of new male germ-line functions from X-derived autosomal retrogenes in the mouse","volume":"24","author":"Shiao","year":"2007","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib30","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-genet-112414-055145","article-title":"Meiotic Silencing in mammals","volume":"49","author":"Turner","year":"2015","journal-title":"Ann Rev Genet"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib31","doi-asserted-by":"crossref","first-page":"11695","DOI":"10.1073\/pnas.0401130101","article-title":"The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b","volume":"101","author":"Rohozinski","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1095\/biolreprod.109.079699","article-title":"Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice","volume":"82","author":"Danshina","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib33","first-page":"3204","article-title":"Germline deletion of Cetn1 causes infertility in male mice","volume":"126","author":"Avasthi","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib34","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1095\/biolreprod.109.083238","article-title":"Infertility with impaired zona pellucida adhesion of spermatozoa from mice lacking TauCstF-64","volume":"83","author":"Tardif","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib35","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1093\/nar\/gkf696","article-title":"Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes","volume":"30","author":"Uechi","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.fertnstert.2019.10.029_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000494","article-title":"Chromosomal redistribution of male-biased genes in mammalian evolution with two bursts of gene gain on the X chromosome","volume":"8","author":"Zhang","year":"2010","journal-title":"PLoS Biol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219324999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219324999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:15:09Z","timestamp":1762150509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028219324999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0015028219324999"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.10.029","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A homozygous RPL10L missense mutation associated with male\u00a0factor\u00a0infertility and severe oligozoospermia","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.10.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92019 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}