{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:29:33Z","timestamp":1790216973543,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":786,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","award":["U54 HD28934"],"award-info":[{"award-number":["U54 HD28934"]}],"id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["UL1 TR00015"],"award-info":[{"award-number":["UL1 TR00015"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.fertnstert.2019.12.012","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T22:19:19Z","timestamp":1583705959000},"page":"876-884.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adjusting antim\u00fcllerian hormone levels for age and body mass index improves detection of polycystic ovary syndrome"],"prefix":"10.1016","volume":"113","author":[{"given":"Glenn E.","family":"Palomaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanu","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita S.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Savjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Torchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dunaif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geralyn M.","family":"Lambert-Messerlian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2019.12.012_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib3","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15112589","article-title":"Geographical prevalence of polycystic ovary syndrome as determined by region and race\/ethnicity","volume":"15","author":"Wolf","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib6","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/humrep\/deu076","article-title":"The role of AMH in anovulation associated with PCOS: a hypothesis","volume":"29","author":"Homburg","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/humrep\/det469","article-title":"The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria vs. revised criteria including anti-Mullerian hormone","volume":"29","author":"Lauritsen","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib8","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.fertnstert.2015.12.023","article-title":"Comparative assessment of five serum antimullerian hormone assays for the diagnosis of polycystic ovary syndrome","volume":"105","author":"Pigny","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1210\/jc.2005-2076","article-title":"Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome","volume":"91","author":"Pigny","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib10","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1210\/me.2010-0273","article-title":"Processing of anti-Mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta","volume":"24","author":"di Clemente","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib11","doi-asserted-by":"crossref","first-page":"18961","DOI":"10.1016\/S0021-9258(18)37375-7","article-title":"Proteolytic processing of mullerian inhibiting substance produces a transforming growth factor-beta-like fragment","volume":"263","author":"Pepinsky","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/molehr\/gaw022","article-title":"Reply: Methodological considerations in measuring different AMH splice forms using ELISA: validity of proAMH ELISA","volume":"22","author":"Mamsen","year":"2016","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/molehr\/gav024","article-title":"Proteolytic processing of anti-Mullerian hormone differs between human fetal testes and adult ovaries","volume":"21","author":"Mamsen","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s10815-015-0538-7","article-title":"Obesity adversely affects serum anti-mullerian hormone (AMH) levels in Caucasian women","volume":"32","author":"Moy","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib15","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1093\/humrep\/des213","article-title":"Anti-Mullerian hormone in the diagnosis of polycystic ovary syndrome: can morphologic description be replaced?","volume":"27","author":"Eilertsen","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib16","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: implications, etiology, and management","volume":"140","author":"Hatch","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib18","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1038\/ncomms8502","article-title":"Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations","volume":"6","author":"Hayes","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib19","doi-asserted-by":"crossref","first-page":"E185","DOI":"10.1210\/jc.2012-2471","article-title":"Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry","volume":"98","author":"Mutharasan","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib20","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/oby.2011.400","article-title":"Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS","volume":"20","author":"Yalamanchi","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib21","first-page":"3299","article-title":"The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome","volume":"81","author":"Dunaif","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib22","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0002-9378(87)90309-7","article-title":"Maternal serum alpha-fetoprotein, age, and Down syndrome risk","volume":"156","author":"Palomaki","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib24","first-page":"56","article-title":"First and second trimester antenatal screening for Down\u2019s syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)","volume":"10","author":"Wald","year":"2003","journal-title":"J Med Screen"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/cen.13795","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"89","author":"Teede","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib26","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1115::AID-PD3>3.0.CO;2-6","article-title":"Refinements in managing maternal weight adjustment for interpreting prenatal screening results","volume":"16","author":"Neveux","year":"1996","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib27","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/(SICI)1097-0223(199808)18:8<842::AID-PD339>3.0.CO;2-G","article-title":"Alternative methods of maternal weight adjustment in maternal serum screening for Down syndrome and neural tube defects","volume":"18","author":"Watt","year":"1998","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib28","author":"Haponiuk"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks\u00a0related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib30","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.fertnstert.2018.06.037","article-title":"Dietary factors and serum antimullerian hormone concentrations in late premenopausal women","volume":"110","author":"Anderson","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.012_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.21767\/2386-5180.100061","article-title":"Reliability of AMH in serum after long-term storage at \u201380\u00b0C and an extended thawing episode","volume":"4","author":"Morse","year":"2016","journal-title":"Ann Clin Lab Res"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219326135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219326135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:51:28Z","timestamp":1777405888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028219326135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0015028219326135"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.12.012","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adjusting antim\u00fcllerian hormone levels for age and body mass index improves detection of polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92019 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}