{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:34:27Z","timestamp":1792809267339,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":786,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.fertnstert.2019.12.018","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T22:19:27Z","timestamp":1583705967000},"page":"828-835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Ultralong administration of gonadotropin-releasing hormone agonists before in\u00a0vitro fertilization improves fertilization rate but not clinical pregnancy rate in women with mild endometriosis: a prospective, randomized, controlled trial"],"prefix":"10.1016","volume":"113","author":[{"given":"Apostolos","family":"Kaponis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-7641","authenticated-orcid":false,"given":"Grigoris","family":"Chatzopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minas","family":"Paschopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Georgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaggelis","family":"Paraskevaidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Zikopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-6766","authenticated-orcid":false,"given":"Konstantinos","family":"Tsiveriotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-0871","authenticated-orcid":false,"given":"George","family":"Adonakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2019.12.018_bib1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0889-8545(05)70302-8","article-title":"Epidemiology of endometriosis","volume":"24","author":"Eskenazi","year":"1997","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0015-0282(02)03112-6","article-title":"Effect of endometriosis on in\u00a0vitro fertilization","volume":"77","author":"Barnhart","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S1472-6483(10)60138-1","article-title":"IVF outcome in women with endometriosis in relation to tumour necrosis factor and anti-m\u00fcllerian hormone","volume":"18","author":"Falconer","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/humrep\/10.suppl_2.91","article-title":"Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction","volume":"10","author":"Pellicer","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(01)01816-7","article-title":"Role of cytokines in endometriosis","volume":"76","author":"Harada","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-0378(01)00130-9","article-title":"New advances in the understanding of endometriosis related infertility","volume":"55","author":"Mahutte","year":"2002","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0897.1988.tb00197.x","article-title":"Cell-mediated immunity in infertility","volume":"17","author":"Anderson","year":"1988","journal-title":"Am J Reprod Immunol Microbiol"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0015-0282(16)59491-6","article-title":"The effect peritoneal fluid from patients with endometriosis on murine sperm-oocyte interaction","volume":"48","author":"Sueldo","year":"1987","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib9","first-page":"824","article-title":"Tumor necrosis factor-alpha promotes proliferation of endometriotic stromal cells by inducing interleukin-8 gene and protein expression","volume":"85","author":"Iwabe","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 3","key":"10.1016\/j.fertnstert.2019.12.018_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humrep\/15.suppl_3.67","article-title":"Ovarian steroid and cytokine modulation of human endometrial angiogenesis","volume":"15","author":"Lebovic","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0015-0282(02)03373-3","article-title":"Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in\u00a0vitro fertilization-embryo transfer in patients with endometriosis","volume":"78","author":"Surrey","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01203749","article-title":"Menotropin stimulation after prolonged gonadotropin releasing hormone agonist pretreatment for in\u00a0vitro fertilization in patients with endometriosis","volume":"9","author":"Nakamura","year":"1992","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib13","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/0002-9378(94)90103-1","article-title":"High rates of pregnancy after long-term down-regulation of women with severe endometriosis","volume":"171","author":"Marcus","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib14","first-page":"179","article-title":"Efficacy of danazol treatment for minimal endometriosis in infertile women: a prospective, randomized study","volume":"33","author":"Bayor","year":"1988","journal-title":"J Reprod Med"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib15","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/0002-9378(92)91602-7","article-title":"Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: a randomized clinical trial","volume":"166","author":"Fedele","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib16","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/0002-9378(94)90133-3","article-title":"Postsurgical medical treatment of advanced endometriosis: results of a randomized clinical trial","volume":"171","author":"Parazzini","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0015-0282(98)00123-X","article-title":"Long term down regulation does not improve PRs in an in\u00a0vitro fertilization program","volume":"70","author":"Fabregues","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib18","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1471-0528.1999.tb08366.x","article-title":"A gonadotropin-releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis","volume":"106","author":"Vercellini","year":"1999","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0015-0282(02)03338-1","article-title":"Increased PRs after ultralong postoperative therapy with gonadotropin-releasing hormone analogues in patients with endometriosis","volume":"78","author":"Rickes","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib20","first-page":"CD004635","article-title":"Long-term pituitary down-regulation before in\u00a0vitro fertilization (IVF) for women with endometriosis","volume":"25","author":"Sallam","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.fertnstert.2007.07.1354","article-title":"Oral contraceptive pill pretreatment in ovarian stimulation with GnRH antagonists for IVF: a systematic review and meta-analysis","volume":"90","author":"Griesinger","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib22","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib23","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0015-0282(98)00484-1","article-title":"The pathogenesis of ovarian hyperstimulation syndrome: in\u00a0vivo studies investigating the role of interleukin-1b, interleukin-6, and vascular endothelial growth factor","volume":"71","author":"Pellicer","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3109\/13547500903183970","article-title":"Cytokine array analysis of peritoneal fluid between women with endometriosis of different stages and those without endometriosis","volume":"14","author":"Hou","year":"2009","journal-title":"Biomarkers"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.8755-8920.2001.450307.x","article-title":"Association between interleukin concentration in FF and intracytoplasmic sperm injection (ICSI) outcome","volume":"45","author":"Hammadeh","year":"2001","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humupd\/6.1.67","article-title":"Follicular hormonal environment and embryo quality in women with endometriosis","volume":"6","author":"Garrido","year":"2000","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/00016340500501715","article-title":"Increased ENA-78 in the FF of patients with endometriosis","volume":"85","author":"Wunder","year":"2006","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/humrep\/dep437","article-title":"Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy","volume":"25","author":"Khan","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib29","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.fertnstert.2008.11.033","article-title":"The human ovarian FF level of interleukine-8 is associated with follicular size and patient age","volume":"93","author":"Malizia","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib30","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/humrep\/den192","article-title":"Cytokines and chemokines in FFs and potential of the corresponding embryo: the role of granulocyte colony-stimulating factor","volume":"23","author":"Ledee","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib31","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1093\/humrep\/del217","article-title":"Ovarian follicular concentration of IL-12, IL-15, IL-18 and p40 subunit of IL-12 and Il-23","volume":"21","author":"Vujisic","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib32","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/humrep\/dew148","article-title":"RCT to evaluate the influence of adjuvant medical treatment of peritoneal endometriosis on the outcome of IVF","volume":"31","author":"Decleer","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2019.12.018_bib33","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.12659\/MSM.916447","article-title":"Efficacy and safety of in\u00a0vitro fertilization (IVF)\/intracytoplasmic sperm injection (ICSI) among patients with endometriosis after a shortened protocol of long-term pituitary downregulation","volume":"25","author":"Kong","year":"2019","journal-title":"Med Sci Monit"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219326202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028219326202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:27:01Z","timestamp":1758011221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028219326202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0015028219326202"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.12.018","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultralong administration of gonadotropin-releasing hormone agonists before in\u00a0vitro fertilization improves fertilization rate but not clinical pregnancy rate in women with mild endometriosis: a prospective, randomized, controlled trial","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2019.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92019 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}