{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:37:32Z","timestamp":1790653052497,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC100073"],"award-info":[{"award-number":["2016YFC100073"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1001303"],"award-info":[{"award-number":["2017YFC1001303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1001602"],"award-info":[{"award-number":["2017YFC1001602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730041"],"award-info":[{"award-number":["81730041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.fertnstert.2020.04.002","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T01:32:23Z","timestamp":1594085543000},"page":"331-337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Coenzyme Q10 supplementation of human oocyte in\u00a0vitro maturation reduces postmeiotic aneuploidies"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-7594","authenticated-orcid":false,"given":"Long","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-6614","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. John\u00e9","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-5844","authenticated-orcid":false,"given":"Jiayin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2020.04.002_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1503\/cmaj.070150","article-title":"Maternal age and risk of stillbirth: a systematic review","volume":"178","author":"Huang","year":"2008","journal-title":"CMAJ"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-5122(98)00068-1","article-title":"Declining fecundity and ovarian ageing in natural fertility populations","volume":"30","author":"O\u2019Connor","year":"1998","journal-title":"Maturitas"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib3","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.fertnstert.2016.01.025","article-title":"Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening","volume":"105","author":"Demko","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrg3245","article-title":"Human aneuploidy: mechanisms and new insights into an age-old problem","volume":"13","author":"Nagaoka","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fertnstert.2012.11.031","article-title":"The aging oocyte-can mitochondrial function be improved?","volume":"99","author":"Bentov","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1095\/biolreprod.109.080887","article-title":"The role of mitochondrial DNA copy number in mammalian fertility","volume":"83","author":"Wai","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib7","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.fertnstert.2005.09.017","article-title":"Mitochondrial content reflects oocyte variability and fertilization outcome","volume":"85","author":"Santos","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/humrep\/deh667","article-title":"Low oocyte mitochondrial DNA content in ovarian insufficiency","volume":"20","author":"May-Panloup","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jcp.22171","article-title":"Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation","volume":"224","author":"Yu","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/jcp.24457","article-title":"Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption","volume":"229","author":"Dalton","year":"2014","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.mito.2010.08.011","article-title":"Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions","volume":"11","author":"Eichenlaub-Ritter","year":"2011","journal-title":"Mitochondrion"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib12","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1242\/dev.01181","article-title":"Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production","volume":"131","author":"Dumollard","year":"2004","journal-title":"Develop"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.mito.2010.09.012","article-title":"Mitochondrial function in the human oocyte and embryo and their role in developmental competence","volume":"11","author":"Van Blerkom","year":"2011","journal-title":"Mitochondrion"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.fertnstert.2009.07.988","article-title":"The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients","volume":"93","author":"Bentov","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib15","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.mito.2007.02.006","article-title":"The antioxidant role of coenzyme Q","volume":"7","author":"Bentinger","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02535072","article-title":"Age-related changes in the lipid compositions of rat and human tissues","volume":"24","author":"Kalen","year":"1989","journal-title":"Lipids"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cccn.2004.04.003","article-title":"Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults","volume":"347","author":"Miles","year":"2004","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib18","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/acel.12368","article-title":"Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging","volume":"14","author":"Ben-Meir","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4137\/CMRH.S14681","article-title":"Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment","volume":"8","author":"Bentov","year":"2014","journal-title":"Clin Med Insights Reprod Health"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib20","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.fertnstert.2014.01.051","article-title":"Development and validation of a next-generation sequencing-based protocol for 24-chromosome aneuploidy screening of embryos","volume":"101","author":"Fiorentino","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib21","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.fertnstert.2017.07.010","article-title":"referential selection and transfer of euploid noncarrier embryos in preimplantation genetic diagnosis cycles for reciprocal translocations","volume":"108","author":"Wang","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.rbmo.2018.07.001","article-title":"Preimplantation genetic testing for complex chromosomal rearrangement carriers by next-generation sequencing","volume":"37","author":"Brunet","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib23","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00439-013-1309-0","article-title":"The origin and impact of embryonic aneuploidy","volume":"132","author":"Fragouli","year":"2013","journal-title":"Hum Genet"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/acel.12016","article-title":"Deficiency of ovarian ornithine decarboxylase contributes to aging-related egg aneuploidy in mice","volume":"12","author":"Tao","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.rbmo.2010.08.014","article-title":"Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing","volume":"22","author":"Kuliev","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF00201839","article-title":"Predivision in human oocytes at meiosis I: a mechanism for trisomy formation in man","volume":"86","author":"Angell","year":"1991","journal-title":"Hum Genet"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1086\/513890","article-title":"First-meiotic-division nondisjunction in human oocytes","volume":"61","author":"Angell","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000133631","article-title":"First meiotic division abnormalities in human oocytes: mechanism of trisomy formation","volume":"65","author":"Angell","year":"1994","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib29","doi-asserted-by":"crossref","first-page":"a016428","DOI":"10.1101\/cshperspect.a016428","article-title":"Sources of DNA double-strand breaks and models of recombinational DNA repair","volume":"6","author":"Mehta","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib30","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/humrep\/dex324","article-title":"The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos","volume":"32","author":"Babariya","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12958-018-0343-0","article-title":"Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial","volume":"16","author":"Xu","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.rbmo.2014.03.011","article-title":"Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome","volume":"29","author":"El Refaeey","year":"2014","journal-title":"Reprod BioMed Online"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib33","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.fertnstert.2015.05.023","article-title":"Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging","volume":"104","author":"Ben-Meir","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.002_bib34","doi-asserted-by":"crossref","first-page":"E6823","DOI":"10.1073\/pnas.1612047113","article-title":"Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors","volume":"113","author":"Perkins","year":"2016","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220303289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220303289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:27:03Z","timestamp":1758011223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028220303289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0015028220303289"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.04.002","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coenzyme Q10 supplementation of human oocyte in\u00a0vitro maturation reduces postmeiotic aneuploidies","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92020 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine","name":"copyright","label":"Copyright"}]}}