{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:26:07Z","timestamp":1790267167153,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.fertnstert.2020.04.005","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T17:58:40Z","timestamp":1593626320000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Endometrial extracellular vesicles from women with recurrent implantation failure attenuate the growth and invasion of embryos"],"prefix":"10.1016","volume":"114","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junning","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-4339","authenticated-orcid":false,"given":"Cong","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2020.04.005_bib1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/humupd\/dml004","article-title":"Endometrial receptivity markers, the journey to successful embryo implantation","volume":"12","author":"Achache","year":"2006","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","article-title":"Exosome-mediated metastasis: communication from a distance","volume":"49","author":"Wortzel","year":"2019","journal-title":"Dev Cell"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib4","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib6","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/sj.leu.2404296","article-title":"Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib7","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1242\/dev.124289","article-title":"Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome","volume":"142","author":"Vilella","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib8","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180036","article-title":"MiR-21 in extracellular vesicles contributes to the growth of fertilized eggs and embryo development in mice","volume":"38","author":"Lv","year":"2018","journal-title":"Biosci Rep"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090913","article-title":"Extracellular vesicles in luminal fluid of the ovine uterus","volume":"9","author":"Burns","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/biolre\/ioy263","article-title":"Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine modeldagger","volume":"100","author":"Marinaro","year":"2019","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.fertnstert.2012.03.010","article-title":"Repeated implantation failure: clinical approach","volume":"97","author":"Simon","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib12","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.fertnstert.2009.07.1668","article-title":"Defective endometrial prostaglandin synthesis identified in patients with repeated implantation failure undergoing in\u00a0vitro fertilization","volume":"94","author":"Achache","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib14","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00404-013-3131-2","article-title":"The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients","volume":"289","author":"Yang","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13170","article-title":"Oxidative stress, inflammatory settings, and microRNA regulation in the recurrent implantation failure patients with metabolic syndrome","volume":"82","author":"Sheikhansari","year":"2019","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.fertnstert.2018.11.016","article-title":"Association between estrogen receptor 1 (ESR1) and leukemia inhibitory factor (LIF) polymorphisms can help in the prediction of recurrent implantation failure","volume":"111","author":"Vagnini","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib17","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1093\/humrep\/dep193","article-title":"Disrupted gene pattern in patients with repeated in\u00a0vitro fertilization (IVF) failure","volume":"24","author":"Koler","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib18","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/humrep\/dey023","article-title":"Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure","volume":"33","author":"Sebastian-Leon","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fertnstert.2018.03.017","article-title":"Effects of chronic endometritis therapy on in\u00a0vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis","volume":"110","author":"Vitagliano","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/GCO.0000000000000468","article-title":"Implantation failure of endometrial origin: what is new?","volume":"30","author":"Bellver","year":"2018","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib21","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/1933719118792104","article-title":"Potential marker pathways in the endometrium that may cause recurrent implantation failure","volume":"26","author":"Bastu","year":"2019","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.rbmo.2018.11.022","article-title":"Endometrial stromal cell proteome mapping in repeated implantation failure and recurrent pregnancy loss cases and fertile women","volume":"38","author":"Dhaenens","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib23","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/humrep\/dey022","article-title":"Decreased PECAM1-mediated TGF-beta1 expression in the mid-secretory endometrium in women with recurrent implantation failure","volume":"33","author":"Guo","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib24","doi-asserted-by":"crossref","first-page":"19411","DOI":"10.1038\/srep19411","article-title":"An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF","volume":"6","author":"Koot","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib25","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.fertnstert.2019.04.017","article-title":"Should we stop offering endometrial scratching prior to in\u00a0vitro fertilization?","volume":"111","author":"Lensen","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib26","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0015-0282(03)00345-5","article-title":"Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in\u00a0vitro fertilization","volume":"79","author":"Barash","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib27","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0538","article-title":"Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo","volume":"369","author":"Bedzhov","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jprot.2016.05.026","article-title":"Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy: the role of ovarian steroid and pregnancy hormones","volume":"144","author":"Greening","year":"2016","journal-title":"J Proteomics"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib29","doi-asserted-by":"crossref","first-page":"3.22.1","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","volume":"30","author":"Thery","year":"2006","journal-title":"Curr Protoc Cell Biol"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib30","first-page":"804","article-title":"MiR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R","volume":"128","author":"Kang","year":"2015","journal-title":"J Cell Sci"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib31","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/humrep\/der037","article-title":"The Istanbul Consensus Workshop on Embryo Assessment: proceedings of an expert meeting","volume":"26","author":"Balaban","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib32","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1093\/humrep\/der255","article-title":"MicroRNAs are associated\u00a0with human embryo implantation defects","volume":"26","author":"Revel","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib33","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.7150\/ijbs.25081","article-title":"Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity","volume":"14","author":"Feng","year":"2018","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/ijms20020425","article-title":"A proteome approach reveals differences between fertile women and patients with repeated implantation failure on endometrial level\u2014does hCG render the endometrium of RIF patients?","volume":"20","author":"Bielfeld","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196080","article-title":"Murine embryos exposed to human endometrial MSCs\u2013derived extracellular vesicles exhibit higher VEGF\/PDGF AA release, increased blastomere count and hatching rates","volume":"13","author":"Blazquez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1095\/biolreprod.115.134890","article-title":"Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial-embryo interactions","volume":"94","author":"Greening","year":"2016","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib37","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1242\/dev.003798","article-title":"Stochastic patterning in the mouse pre-implantation embryo","volume":"134","author":"Dietrich","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib38","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.celrep.2014.08.027","article-title":"Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes","volume":"8","author":"Koppers-Lalic","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.tim.2018.02.009","article-title":"Extracellular vesicle RNA: a universal mediator of microbial communication?","volume":"26","author":"Tsatsaronis","year":"2018","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1095\/biolreprod.116.143503","article-title":"Extracellular vesicles in the intrauterine environment: challenges and potential functions","volume":"95","author":"Nguyen","year":"2016","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib41","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.actbio.2019.05.054","article-title":"Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery","volume":"94","author":"Rayamajhi","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J Cell Biol"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib43","doi-asserted-by":"crossref","first-page":"e1413","DOI":"10.1002\/wrna.1413","article-title":"RNA in extracellular vesicles","volume":"8","author":"Kim","year":"2017","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.lfs.2018.08.005","article-title":"Tumor necrosis factor-alpha suppresses the invasion of HTR-8\/SVneo trophoblast cells through microRNA-145-5p\u2013mediated downregulation of Cyr61","volume":"209","author":"Wen","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib45","article-title":"Endometrial exosomes\/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation","volume":"8","author":"Ng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib46","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/sj.leu.2404132","article-title":"Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.fertnstert.2020.04.005_bib47","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat Cell Biol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220303332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220303332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:26:38Z","timestamp":1758011198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028220303332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0015028220303332"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.04.005","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endometrial extracellular vesicles from women with recurrent implantation failure attenuate the growth and invasion of embryos","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92020 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}