{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:24:36Z","timestamp":1790436276041,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":572,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.fertnstert.2020.05.043","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:07:40Z","timestamp":1598602060000},"page":"997-1005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Role of treatment with human chorionic gonadotropin and clinical parameters on testicular sperm recovery with microdissection testicular sperm extraction and intracytoplasmic sperm injection outcomes in 184 Klinefelter syndrome patients"],"prefix":"10.1016","volume":"114","author":[{"given":"Feixiang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2020.05.043_bib1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study","volume":"88","author":"Bojesen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/humrep\/dep431","article-title":"Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009?","volume":"25","author":"Fullerton","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000086906","article-title":"Somatic chromosomal abnormalities in infertile men and women","volume":"111","author":"Mau-Holzmann","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(04)16678-6","article-title":"Klinefelter\u2019s syndrome","volume":"364","author":"Lanfranco","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-1172-1-42","article-title":"Klinefelter syndrome and other sex chromosomal aneuploidies","volume":"1","author":"Visootsak","year":"2006","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/jc.2012-2382","article-title":"Clinical review: Klinefelter syndrome\u2014a clinical update","volume":"98","author":"Groth","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib7","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/EJE-12-0934","article-title":"Testicular function and fertility in men with Klinefelter syndrome: a review","volume":"168","author":"Aksglaede","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/humupd\/dmi039","article-title":"Natural history of seminiferous tubule degeneration in Klinefelter syndrome","volume":"12","author":"Aksglaede","year":"2006","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib9","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/humrep\/dey094","article-title":"When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome?","volume":"33","author":"Van Saen","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/humupd\/dmx008","article-title":"Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis","volume":"23","author":"Corona","year":"2017","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib11","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/humrep\/dew179","article-title":"Klinefelter syndrome and fertility: sperm preservation should not be offered\u00a0to children with Klinefelter syndrome","volume":"31","author":"Franik","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000316604","article-title":"Klinefelter\u2019s syndrome: a clinical and therapeutical update","volume":"4","author":"Forti","year":"2010","journal-title":"Sex Dev"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.fertnstert.2015.12.011","article-title":"Testicular biopsy and cryopreservation for fertility preservation of prepubertal boys with Klinefelter syndrome: a pro\/con debate","volume":"105","author":"Gies","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib14","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.fertnstert.2005.05.053","article-title":"Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter\u2019s syndrome","volume":"84","author":"Okada","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib15","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1016\/j.urology.2006.05.028","article-title":"Aging may adversely affect testicular sperm recovery in patients with Klinefelter syndrome","volume":"68","author":"Bakircioglu","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1439-0272.2008.00875.x","article-title":"Age as only predictive factor for successful sperm recovery in patients with Klinefelter\u2019s syndrome","volume":"41","author":"Ferhi","year":"2009","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib17","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/humrep\/deh253","article-title":"H.T. Can biological or clinical parameters predict testicular sperm recovery in 47,XXY Klinefelter\u2019s syndrome patients?","volume":"19","author":"Vernaeve","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/cen.13572","article-title":"Novel insights on testicular volume and testosterone replacement therapy in Klinefelter patients undergoing testicular sperm extraction: a retrospective clinical study","volume":"88","author":"Garolla","year":"2018","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib19","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S0015-0282(03)00403-5","article-title":"Low levels of serum inhibin B do not exclude successful sperm recovery in men with nonmosaic Klinefelter syndrome","volume":"79","author":"Westlander","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0950-3552(97)80035-1","article-title":"A critical review of the origin and control of adrenal androgens","volume":"11","author":"McKenna","year":"1997","journal-title":"Baillieres Clin Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/1008-682X.122201","article-title":"The role of hypogonadism in Klinefelter syndrome","volume":"16","author":"Host","year":"2014","journal-title":"Asian J Androl"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib22","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1530\/EJE-15-1224","article-title":"Human chorionic gonadotropin stimulation gives evidence of differences in testicular steroidogenesis in Klinefelter syndrome, as assessed by liquid chromatography-tandem mass spectrometry","volume":"174","author":"Belli","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib23","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1210\/jc.2012-1598","article-title":"Clinical review: Distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests","volume":"97","author":"Harrington","year":"2012","journal-title":"J Clin Endocrinol Meta"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib24","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0015-0282(02)03092-3","article-title":"Prognostic value of the clinical and laboratory evaluation in patients with","author":"Madgar","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib25","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.juro.2009.05.019","article-title":"Successful fertility treatment for Klinefelter\u2019s syndrome","volume":"182","author":"Ramasamy","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000326057","article-title":"Normative values for testicular volume measured by ultrasonography in a normal population from infancy to adolescence","volume":"76","author":"Goede","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib27","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1464-410X.2003.04772.x","article-title":"Correlation of ultrasonographic and orchidometer measurements of testis volume in adults","volume":"93","author":"Schiff","year":"2004","journal-title":"BJU Int"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/humupd\/4.4.439","article-title":"Microdissection TESE: sperm retrieval in non-obstructive azoospermia","volume":"4","author":"Schlegel","year":"1998","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib29","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/S0140-6736(01)06797-6","article-title":"Gonadotropin-releasing-hormone-receptor antagonists","volume":"358","author":"Huirne","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/humrep\/dex012","article-title":"The addition of anti-M\u00fcllerian hormone in an algorithm for individualized hormone dosage did not improve the prediction of ovarian response\u2014a randomized, controlled trial","volume":"32","author":"Magnusson","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib31","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.fertnstert.2011.02.008","article-title":"Utility of the national embryo morphology data collection by the Society for Assisted Reproductive Technologies (SART): correlation between day-3 morphology grade and live-birth outcome","volume":"95","author":"Vernon","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ajmg.c.31349","article-title":"47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management","volume":"163C","author":"Aksglaede","year":"2013","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-0029-1202305","article-title":"Nonobstructive azoospermia: a revolutionary surgical approach and results","volume":"27","author":"Schlegel","year":"2009","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1651-2227.2011.02246.x","article-title":"Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience","volume":"100","author":"Aksglaede","year":"2011","journal-title":"Acta Paediat"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.fertnstert.2012.06.001","article-title":"Klinefelter syndrome: an argument for early aggressive hormonal and fertility management","volume":"98","author":"Mehta","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/and.13004","article-title":"Klinefelter syndrome and fertility-Impact of X-chromosomal inheritance on spermatogenesis","volume":"50","author":"Franik","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046682","article-title":"LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling","volume":"7","author":"Casarini","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib38","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0015-0282(02)03092-3","article-title":"Prognostic value of the clinical and laboratory evaluation in patients with nonmosaic Klinefelter syndrome who are receiving assisted reproductive therapy","volume":"77","author":"Madgar","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib39","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.fertnstert.2013.06.010","article-title":"Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor","volume":"100","author":"Mehta","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib40","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/EJE-14-0213","article-title":"Management of Klinefelter syndrome during transition","volume":"171","author":"Gies","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib41","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.juro.2012.04.002","article-title":"Role of optimizing testosterone before microdissection testicular sperm extraction in men with nonobstructive azoospermia","volume":"188","author":"Reifsnyder","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib42","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/humrep\/dew147","article-title":"Prediction model for obtaining spermatozoa with testicular sperm extraction in men with non-obstructive azoospermia","volume":"31","author":"Cissen","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib43","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/oxfordjournals.humrep.a019463","article-title":"Preimplantation diagnosis for X and Y normality in embryos from three Klinefelter patients","volume":"11","author":"Staessen","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.05.043_bib44","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1093\/humrep\/12.11.2447","article-title":"Delivery of normal twins following the intracytoplasmic injection of spermatozoa from a patient with 47,XXY Klinefelter\u2019s syndrome","volume":"12","author":"Bourne","year":"1997","journal-title":"Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220305343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220305343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:27:53Z","timestamp":1758011273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028220305343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0015028220305343"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.05.043","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738597331.793580640","asserted-by":"object"}]},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of treatment with human chorionic gonadotropin and clinical parameters on testicular sperm recovery with microdissection testicular sperm extraction and intracytoplasmic sperm injection outcomes in 184 Klinefelter syndrome patients","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.05.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92020 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}