{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:38:36Z","timestamp":1788791916791,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008143","name":"Oregon National Primate Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016206","name":"Clinical and Translational Science Institute, University of California, Los Angeles","doi-asserted-by":"publisher","award":["UL1TR001881"],"award-info":[{"award-number":["UL1TR001881"]}],"id":[{"id":"10.13039\/100016206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50HD071836"],"award-info":[{"award-number":["P50HD071836"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51 ODO11092"],"award-info":[{"award-number":["P51 ODO11092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.fertnstert.2020.10.003","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T08:48:01Z","timestamp":1608194881000},"page":"232-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Accelerated subcutaneous abdominal stem cell adipogenesis predicts insulin sensitivity in normal-weight women with polycystic ovary syndrome"],"prefix":"10.1016","volume":"116","author":[{"given":"Daniel A.","family":"Dumesic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayli","family":"Tulberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha C.","family":"Fisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan R.","family":"Grogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajanigandha","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio D.","family":"Chazenbalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2020.10.003_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coemr.2020.02.013","article-title":"Endocrine-metabolic dysfunction in polycystic ovary syndrome: an evolutionary perspective","volume":"12","author":"Dumesic","year":"2020","journal-title":"Curr Opin Endocr Metab Res"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/humupd\/dmq001","article-title":"Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"16","author":"Moran","year":"2010","journal-title":"Hum Repro Update"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/jc.2005-1329","article-title":"PCOS\/Troglitazone Study Group. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome","volume":"91","author":"Ehrmann","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib5","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1210\/jc.2004-1045","article-title":"Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome","volume":"90","author":"Apridonidze","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/01.AOG.0000167408.30893.6b","article-title":"Screening women with polycystic ovary syndrome for metabolic syndrome","volume":"106","author":"Dokras","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib7","doi-asserted-by":"crossref","first-page":"E726","DOI":"10.1152\/ajpendo.00619.2014","article-title":"Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids","volume":"308","author":"Cree-Green","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib8","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1210\/js.2017-00192","article-title":"Insulin resistance, hyperinsulinemia, and mitochondria dysfunction in nonobese girls with polycystic ovarian syndrome","volume":"1","author":"Cree-Green","year":"2017","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib9","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1210\/jc.2017-00047","article-title":"How to measure adipose tissue insulin sensitivity","volume":"102","author":"S\u00f8ndergaard","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib10","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1210\/jc.2018-02086","article-title":"Adipose insulin resistance in normal-weight polycystic ovary syndrome women","volume":"104","author":"Dumesic","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib11","first-page":"E197","article-title":"Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes","volume":"264","author":"Rosenbaum","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib12","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.fertnstert.2007.10.025","article-title":"Adipocytes from women with polycystic ovary syndrome demonstrate altered phosphorylation and activity of glycogen synthase kinase 3","volume":"90","author":"Chang","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib13","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1210\/jc.2002-021573","article-title":"Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome","volume":"88","author":"Faulds","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib14","first-page":"1147","article-title":"Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance?","volume":"82","author":"Ek","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib15","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.3390\/nu7115475","article-title":"The subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis","volume":"7","author":"Saponaro","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/apha.12246","article-title":"Adipose tissue and its role in organ crosstalk","volume":"210","author":"Romacho","year":"2014","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib17","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.steroids.2013.05.001","article-title":"Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation","volume":"78","author":"Chazenbalk","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib18","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrm3198","article-title":"Forming functional fat: a growing understanding of adipocyte differentiation","volume":"12","author":"Cristancho","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-052110-115718","article-title":"Adipogenesis: from stem cell to adipocyte","volume":"7","author":"Tang","year":"2012","journal-title":"Annual Rev Biochem"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib20","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.fertnstert.2018.08.042","article-title":"Precocious subcutaneous abdominal stem cell development to adipocytes in normal-weight polycystic ovary syndrome women","volume":"110","author":"Fisch","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib21","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1210\/jc.2016-2586","article-title":"Hyperandrogenism is accompanied by preferential intra-abdominal fat storage in normal weight polycystic ovary syndrome women","volume":"101","author":"Dumesic","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/diab.42.2.250","article-title":"Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies","volume":"42","author":"Steil","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/bbrc.1999.1620","article-title":"The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105)","volume":"265","author":"Barry","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib25","series-title":"Biometry, the principles and practice of statistics in biological research","author":"Sokal","year":"1995"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib26","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1242\/jcs.079699","article-title":"Adipogenesis at a glance","volume":"124","author":"Lowe","year":"2011","journal-title":"J Cell Sci"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.molcel.2017.04.010","article-title":"Dynamic rewiring of promoter-anchored chromatin loops during adipocyte differentiation","volume":"66","author":"Siersbaek","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBP\u03b1 induces adipogenesis through PPARg: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPAR\u03b3 signaling and metabolism: the good, the bad and the future","volume":"19","author":"Ahmadian","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2015.02.043","article-title":"A step ahead of PPAR\u03b3 full agonists to PPAR\u03b3 partial agonists: therapeutic perspectives in the management of diabetic insulin resistance","volume":"755","author":"Chigurupati","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib31","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1210\/jc.2008-0574","article-title":"CCAAT\/Enhancer Binding Protein \u03b1 (C\/EBP\u03b1) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C\/EBP\u03b1 is associated with serum levels of triglycerides","volume":"93","author":"Olofsson","year":"2008","journal-title":"J Clin Endo Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/818945","article-title":"Cross-talk between PPAR\u03b3 and insulin signaling and modulation of insulin sensitivity","volume":"2009","author":"Leonardini","year":"2009","journal-title":"PPAR Res"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib33","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1210\/jc.2017-00597","article-title":"Markers of adipogenesis, but not inflammation, in adipose tissue are independently related to insulin sensitivity","volume":"102","author":"Matulewicz","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2796.2004.01426.x","article-title":"Adiponectin-journey from an adipocyte secretory protein to biomarker of metabolic syndrome","volume":"257","author":"Trujillo","year":"2005","journal-title":"J Int Med"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib35","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.2337\/diacare.26.12.3315","article-title":"Plasma adiponectin and endogenous glucose production in humans","volume":"26","author":"Stefan","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib36","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbadis.2013.05.009","article-title":"Direct and indirect effects of leptin on adipocyte metabolism","volume":"1842","author":"Harris","year":"2014","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1677\/joe.1.07070","article-title":"Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women","volume":"192","author":"Corbould","year":"2007","journal-title":"J Endocrinol"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib38","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.2337\/db16-1320","article-title":"Indirect regulation of endogenous glucose production by insulin: the single gateway hypothesis revisited","volume":"66","author":"Bergman","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/17446651.2019.1576522","article-title":"Hyperandrogenic origins of polycystic ovary syndrome \u2013 implications for pathophysiology and therapy","volume":"14","author":"Abbott","year":"2019","journal-title":"Expert Rev Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/OGX.0000000000000661","article-title":"Polycystic ovary syndrome: impact of lipotoxicity on metabolic and reproductive health","volume":"74","author":"Brennan","year":"2019","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib41","doi-asserted-by":"crossref","first-page":"E1088","DOI":"10.1210\/jc.2013-1295","article-title":"Referral bias in defining the phenotype and prevalence of obesity in polycystic ovary syndrome","volume":"98","author":"Ezeh","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib42","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1210\/jc.2016-1376","article-title":"Adipose insulin resistance in obese adolescents across the spectrum of glucose tolerance","volume":"101","author":"Hershkop","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/humupd\/dmy007","article-title":"Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression","volume":"24","author":"Kakoly","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib44","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.2337\/diacare.25.8.1351","article-title":"Heterogeneity in the relationship between ethnicity, BMI, and fasting insulin","volume":"25","author":"Palaniappan","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fertnstert.2020.10.003_bib45","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1210\/jc.2017-00947","article-title":"AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome","volume":"102","author":"O\u2019Reilly","year":"2017","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220325115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220325115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:15:52Z","timestamp":1762150552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028220325115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0015028220325115"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.10.003","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accelerated subcutaneous abdominal stem cell adipogenesis predicts insulin sensitivity in normal-weight women with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92020 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}