{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:06:05Z","timestamp":1791986765867,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.fertnstert.2020.11.041","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T15:26:46Z","timestamp":1615044406000},"page":"1212-1224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":201,"title":["Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1844-2571","authenticated-orcid":false,"given":"Manuel","family":"Viotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Victor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christo G.","family":"Zouves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andria G.","family":"Besser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Grifo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Hui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maw-Sheng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Horcajadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Corti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Spinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giulia","family":"Minasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Munn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2020.11.041_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/humupd\/dmu016","article-title":"The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans","volume":"20","author":"Taylor","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib2","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMc1500421","article-title":"Healthy babies after intrauterine transfer of mosaic aneuploid blastocysts","volume":"373","author":"Greco","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00439-017-1797-4","article-title":"Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts","volume":"136","author":"Fragouli","year":"2017","journal-title":"Hum Genet"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fertnstert.2017.05.002","article-title":"Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing","volume":"108","author":"Munn\u00e9","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2019.103741","article-title":"Clinical outcomes after the transfer of blastocysts characterized as mosaic by high resolution Next Generation Sequencing- further insights","volume":"63","author":"Munn\u00e9","year":"2020","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.fertnstert.2017.09.025","article-title":"Extent of chromosomal mosaicism influences the clinical outcome of in\u00a0vitro fertilization treatments","volume":"109","author":"Spinella","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.fertnstert.2018.10.019","article-title":"One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies","volume":"111","author":"Victor","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib8","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/humrep\/dey106","article-title":"Chromosomal mosaicism in human blastocysts: the ultimate challenge of preimplantation genetic testing?","volume":"33","author":"Popovic","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib9","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.fertnstert.2018.02.008","article-title":"Karyotype of the blastocoel fluid demonstrates low concordance with both trophectoderm and inner cell mass","volume":"109","author":"Tsuiko","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib10","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.fertnstert.2016.01.016","article-title":"Mosaicism: \u201csurvival of the fittest\u201d versus \u201cno embryo left behind\u201d","volume":"105","author":"Munn\u00e9","year":"2016","journal-title":"Fertil Steril"},{"issue":"Suppl 1","key":"10.1016\/j.fertnstert.2020.11.041_bib12","first-page":"e1","article-title":"PGDIS Position Statement on the Transfer of Mosaic Embryos 2019","volume":"39","author":"Cram","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib13","first-page":"492","article-title":"Detecting mosaicism in trophectoderm biopsies: current challenges and future possibilities","volume":"32","author":"Capalbo","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib14","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1093\/nar\/gks1352","article-title":"Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains","volume":"41","author":"Van der Aa","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.fertnstert.2013.10.031","article-title":"Does the S phase have an impact on the accuracy of comparative genomic hybridization profiles in single fibroblasts and human blastomeres?","volume":"101","author":"Ramos","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.rbmo.2017.01.003","article-title":"Counselling considerations for chromosomal mosaicism detected by preimplantation genetic screening","volume":"34","author":"Besser","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.fertnstert.2017.03.023","article-title":"Mosaicism between trophectoderm and inner cell mass","volume":"107","author":"Capalbo","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.rbmo.2018.04.046","article-title":"Scoring of mosaic embryos after preimplantation genetic testing: a rollercoaster ride between fear, hope and embryo wastage","volume":"37","author":"Murtinger","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib19","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.fertnstert.2016.08.017","article-title":"Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing","volume":"106","author":"Maxwell","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13039-015-0143-6","article-title":"Application of next-generation sequencing for 24-chromosome aneuploidy screening of human preimplantation embryos","volume":"8","author":"Zheng","year":"2015","journal-title":"Mol Cytogenet"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib21","series-title":"Towards reproductive certainty: fertility and genetics beyond","first-page":"378","article-title":"In\u00a0vitro culture of human blastocysts","author":"Gardner","year":"1999"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ajhg.2020.03.005","article-title":"Incidence, origin, and predictive model for the detection and clinical management of segmental aneuploidies in human embryos","volume":"106","author":"Girardi","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/molehr\/gaaa012","article-title":"Concordance of various chromosomal errors among different parts of the embryo and the value of re-biopsy in embryos with segmental aneuploidies","volume":"26","author":"Navratil","year":"2020","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/humrep\/dey327","article-title":"Assessment of aneuploidy concordance between clinical trophectoderm biopsy\u00a0and blastocyst","volume":"34","author":"Victor","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10815-017-0875-9","article-title":"Re-analysis of aneuploidy blastocysts with an inner cell mass and different regional trophectoderm cells","volume":"34","author":"Huang","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/humrep\/dez055","article-title":"The clinicians dilemma with mosaicism-an insight from inner cell mass biopsies","volume":"34","author":"Lawrenz","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10815-020-01720-x","article-title":"The reproducibility of trophectoderm biopsies in euploid, aneuploid, and mosaic embryos using independently verified next-generation sequencing (NGS): a pilot study","volume":"37","author":"Sachdev","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tig.2011.07.003","article-title":"The aneuploidy paradox: costs and benefits of an incorrect karyotype","volume":"27","author":"Sheltzer","year":"2011","journal-title":"Trends Genet"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib29","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.1038\/ncomms11165","article-title":"Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential","volume":"7","author":"Bolton","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib30","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1038\/s41467-020-16796-3","article-title":"Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism","volume":"11","author":"Singla","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib31","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/humrep\/dez012","article-title":"Extended in\u00a0vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy","volume":"34","author":"Popovic","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.rbmo.2019.05.020","article-title":"Embryo morphokinetics is potentially associated with clinical outcomes of single-embryo transfers in preimplantation genetic testing for aneuploidy cycles","volume":"39","author":"Lee","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.fertnstert.2013.08.051","article-title":"Uniparental disomy in the human blastocyst is exceedingly rare","volume":"101","author":"Gueye","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2020.08.111","article-title":"A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy","author":"Tiegs","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib35","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3390\/genes11060602","article-title":"Preimplantation genetic testing for chromosomal abnormalities: aneuploidy, mosaicism, and structural rearrangements","volume":"11","author":"Viotti","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40246-019-0253-z","article-title":"Re-analysis of whole blastocysts after trophectoderm biopsy indicated chromosome aneuploidy","volume":"14","author":"Ou","year":"2020","journal-title":"Hum Genomics"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib37","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/humrep\/dez309","article-title":"The birth of a baby with mosaicism resulting from a known mosaic embryo transfer: a case report","volume":"35","author":"Kahraman","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib38","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.fertnstert.2018.10.001","article-title":"What are patients doing with their mosaic embryos? Decision making after genetic counseling","volume":"111","author":"Besser","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2020.11.041_bib39","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.fertnstert.2019.07.1346","article-title":"Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial","volume":"112","author":"Munn\u00e9","year":"2019","journal-title":"Fertil Steril"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220327163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028220327163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:29:48Z","timestamp":1758011388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028220327163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0015028220327163"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.11.041","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2020.11.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92020 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}