{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:20:29Z","timestamp":1791566429189,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.fertnstert.2021.01.044","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T22:22:19Z","timestamp":1623968539000},"page":"198-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"116","author":[{"given":"Yusuf","family":"Beebeejaun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbeyrahmee","family":"Athithan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan S.","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippokratis","family":"Sarris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sesh K.","family":"Sunkara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2021.01.044_bib1","first-page":"135","article-title":"EBM in action: does ovulation induction increase the risk of ovarian cancer?","volume":"11","author":"Attia","year":"2006","journal-title":"Middle East Fertil Soc J"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/1055-9965.EPI-16-0520","article-title":"Cancer Incidence and Survival Trends by Subtype Using Data from the Surveillance Epidemiology and End Results Program, 1992\u20132013","volume":"26","author":"Noone","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/07357908809080645","article-title":"Menstrual factors and risk of breast cancer","volume":"6","author":"Brinton","year":"1988","journal-title":"Cancer Invest"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.epirev.a036102","article-title":"Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk","volume":"15","author":"Pike","year":"1993","journal-title":"Epidemiol Rev"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1472-6483(10)61821-4","article-title":"Clomiphene citrate and ovulation induction","volume":"4","author":"Sovino","year":"2002","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.8023157","article-title":"Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations","volume":"265","author":"Cho","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/oxfordjournals.aje.a114595","article-title":"Cancer incidence in a cohort of infertile women","volume":"125","author":"Ron","year":"1987","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(95)91687-3","article-title":"Breast and ovarian cancer incidence after infertility and in\u00a0vitro fertilisation","volume":"346","author":"Venn","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib9","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/oxfordjournals.aje.a009397","article-title":"Cancer incidence in a cohort of infertile women","volume":"147","author":"Modan","year":"1998","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib10","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/S0140-6736(99)05203-4","article-title":"Risk of cancer after use of fertility drugs with in-vitro fertilisation","volume":"354","author":"Venn","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib11","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/humrep\/17.8.2209","article-title":"Cancer incidence following treatment for infertility at a clinic in the UK","volume":"17","author":"Doyle","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib12","first-page":"319","article-title":"Cancer risk associated with subfertility and ovulation induction: a review","volume":"11","author":"Klip","year":"2000","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/ijgc-00009577-200301000-00004","article-title":"The possible association between in\u00a0vitro fertilization treatments and cancer development","volume":"13","author":"Lerner-Geva","year":"2003","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib14","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/jnci\/djs255","article-title":"Fertility drugs and young-onset breast cancer: results from the Two Sister Study","volume":"104","author":"Fei","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib15","doi-asserted-by":"crossref","first-page":"72.e1","DOI":"10.1016\/j.ajog.2008.08.066","article-title":"Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study","volume":"200","author":"Org\u00e9as","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.rbmo.2015.03.008","article-title":"Does ovarian stimulation for IVF increase gynaecological cancer risk? A systematic review and meta-analysis","volume":"31","author":"Zhao","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/humupd\/dmt034","article-title":"IVF and breast cancer: a systematic review and meta-analysis","volume":"20","author":"Sergentanis","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib18","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses\u00a0of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement","volume":"319","author":"McInnes","year":"2018","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib20","author":"Siemieniuk"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib21","author":"Sterne"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib22","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1158\/1055-9965.EPI-13-0996","article-title":"Long-term relationship of ovulation-stimulating drugs to breast cancer risk","volume":"23","author":"Brinton","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib23","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1093\/humrep\/deh422","article-title":"Breast cancer risk associated with being treated for infertility: results from the French E3N cohort study","volume":"19","author":"Gauthier","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib24","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1158\/1055-9965.EPI-07-0075","article-title":"Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study","volume":"16","author":"Jensen","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3109\/09513590.2012.671391","article-title":"Are infertility treatments a potential risk factor for cancer development? Perspective of 30 years of follow-up","volume":"28","author":"Liat","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib26","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1001\/archinte.166.22.2484","article-title":"A prospective study of infertility due to ovulatory disorders, ovulation induction, and incidence of breast cancer","volume":"166","author":"Terry","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib27","first-page":"1111","article-title":"Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study","volume":"19","year":"2008","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10549-006-9238-4","article-title":"Infertility, ovulation induction treatments and the incidence of breast cancer\u2014a historical prospective cohort of Israeli women","volume":"100","author":"Lerner-Geva","year":"2006","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib29","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1038\/sj.bjc.6605086","article-title":"Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort","volume":"100","author":"Silva Idos","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/gyno.1996.0002","article-title":"Risk of breast cancer in a cohort of infertile women","volume":"60","author":"Rossing","year":"1996","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib31","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0015-0282(99)00085-0","article-title":"Fertility drugs and the risk of breast and ovarian cancers: results of a long-term follow-up study","volume":"71","author":"Potashnik","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.clbc.2018.03.003","article-title":"Breast cancer\u00a0and ovulation induction treatments","volume":"18","author":"Taheripanah","year":"2018","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib33","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0015-0282(02)04950-6","article-title":"Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women\u2019s Contraceptive and Reproductive Experiences Study","volume":"79","author":"Burkman","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib34","first-page":"365","article-title":"Cancer risk after exposure to treatments for ovulation induction","volume":"69","author":"Calderon-Margalit","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib35","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1093\/humrep\/deh371","article-title":"Breast cancer risk associated with ovulation-stimulating drugs","volume":"19","author":"Brinton","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib36","first-page":"139","article-title":"Cancer risk in women treated with fertility drugs according to parity status\u2014a registry-based cohort study","volume":"176","author":"Reigstad","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib37","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.fertnstert.2012.12.029","article-title":"In\u00a0vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services","volume":"99","author":"Brinton","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib38","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.fertnstert.2018.06.039","article-title":"International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2011","volume":"110","author":"Adamson","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.01.044_bib39","article-title":"Risk of endometrial cancer in women treated with ovary-stimulating drugs for subfertility","volume":"3","author":"Skalkidou","year":"2017","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221000777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221000777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:29:59Z","timestamp":1758011399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028221000777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0015028221000777"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.01.044","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.01.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a92021 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine","name":"copyright","label":"Copyright"}]}}