{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:52:37Z","timestamp":1786989157016,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.fertnstert.2021.04.006","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:11:40Z","timestamp":1620432700000},"page":"766-773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in\u00a0vitro fertilization cycles"],"prefix":"10.1016","volume":"116","author":[{"given":"Giulia","family":"Scaravelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Zac\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Emanuele","family":"Levi Setti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Livi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Maria","family":"Ubaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabetta","family":"Coccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Revelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Vigiliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Borini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2021.04.006_bib1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.fertnstert.2011.11.048","article-title":"Multiple gestation associated with infertility therapy: an American Society for Reproductive Medicine Practice Committee opinion","volume":"97","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib2","first-page":"835","article-title":"Practice Committee of Society for Assisted Reproductive Technology, Practice Committee of the American Society for Reproductive Medicine, Elective single-embryo transfer","volume":"97","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib3","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1093\/humrep\/det317","article-title":"Refuting a misguided campaign against the goal of single-embryo transfer and singleton birth in assisted reproduction","volume":"28","author":"Stillman","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJMoa0803072","article-title":"Cumulative live-birth rates after in\u00a0vitro fertilization","volume":"360","author":"Malizia","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib5","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1093\/humrep\/deh446","article-title":"What is the most relevant standard of success in assisted reproduction? The value of cryopreservation on cumulative pregnancy rates per single oocyte retrieval should not be forgotten","volume":"19","author":"Tiitinen","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib6","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/humrep\/deq124","article-title":"Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE","volume":"25","author":"de Mouzon","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib7","first-page":"139","article-title":"Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance","volume":"23","author":"Rienzi","year":"2017","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/humupd\/dmy033","article-title":"Fresh versus elective frozen embryo transfer in IVF\/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes","volume":"25","author":"Roque","year":"2019","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib9","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s10815-019-01581-z","article-title":"Correction to: contribution of cryopreservation to the cumulative live birth rate: a large multicentric cycle-based data analysis from the Italian National Registry","volume":"36","author":"Scaravelli","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.fertnstert.2018.05.012","article-title":"Cumulative live birth rate in freeze-all cycles is comparable to that of a conventional embryo transfer policy at the cleavage stage but superior at the blastocyst stage","volume":"110","author":"Zac\u00e0","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib11","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1093\/humrep\/deh501","article-title":"What is the most relevant standard of success in assisted reproduction?: The cumulated singleton\/twin delivery rates per oocyte pick-up: the CUSIDERA and CUTWIDERA","volume":"19","author":"Germond","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib12","first-page":"2703","article-title":"Cumulative live birth rate: time for a consensus?","volume":"30","author":"Maheshwari","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib13","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s10815-020-01807-5","article-title":"Sperm count affects cumulative birth rate of assisted reproduction cycles in relation to ovarian response","volume":"37","author":"Zac\u00e0","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib14","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1093\/humrep\/der228","article-title":"Factors predicting the cumulative outcome of IVF\/ICSI treatment: a multivariable analysis of 2450 patients","volume":"26","author":"Cai","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.rbmo.2017.06.015","article-title":"The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators","volume":"35","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib16","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/humrep\/dex234","article-title":"The international glossary on infertility and fertility care, 2017","volume":"32","author":"Zegers-Hochschild","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4103\/0974-1208.126286","article-title":"Assisted reproductive technology in India: A 3 year retrospective data analysis","volume":"6","author":"Malhotra","year":"2013","journal-title":"J Hum Reprod Sci"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0015-0282(16)55805-1","article-title":"French National IVF Registry: analysis of 1986 to 1990 data","volume":"59","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4103\/jfmpc.jfmpc_453_18","article-title":"ART registries\u2014characteristics and experiences: a comparative study","volume":"8","author":"Zahmatkeshan","year":"2019","journal-title":"J Fam Med Prim Care"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fertnstert.2012.10.018","article-title":"The cumulative probability of liveborn multiples after in\u00a0vitro fertilization: a cohort study of more than 10,000 women","volume":"99","author":"Malizia","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1642-431X(12)60002-3","article-title":"Timing of the first zygotic cleavage as a marker of developmental potential of mammalian embryos","volume":"8","author":"Lechniak","year":"2008","journal-title":"Reprod Biol"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib22","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S1472-6483(10)61053-X","article-title":"Anti-M\u00fcllerian hormone as a predictor of IVF outcome","volume":"14","author":"Lekamge","year":"2007","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib23","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1093\/humrep\/dem183","article-title":"Predicting ongoing pregnancy chances after IVF and ICSI: a national prospective study","volume":"22","author":"Lintsen","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib24","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/humrep\/der106","article-title":"Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles","volume":"26","author":"Sunkara","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/jbiol167","article-title":"The human spermatozoon\u2014a stripped down but refined machine","volume":"8","author":"Barratt","year":"2009","journal-title":"J Biol"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib26","doi-asserted-by":"crossref","first-page":"R113","DOI":"10.1530\/REP-18-0639","article-title":"Sperm and seminal plasma RNAs: what roles do they play beyond fertilization?","volume":"158","author":"Jodar","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/and.13061","article-title":"Influence of human sperm origin, testicular or ejaculated, on embryo morphokinetic development","volume":"50","author":"Scarselli","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4081\/aiua.2018.4.254","article-title":"The aging male: relationship between male age, sperm quality and sperm DNA damage in an unselected population of 3124 men attending the fertility centre for the first time","volume":"90","author":"Colasante","year":"2019","journal-title":"Arch Ital Urol Androl"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib29","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.fertnstert.2009.05.024","article-title":"Fertilization rate is an independent predictor of implantation rate","volume":"94","author":"Rosen","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/humupd\/dmn025","article-title":"ART failure: oocyte contributions to unsuccessful fertilization","volume":"14","author":"Swain","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.04.006_bib31","first-page":"391","article-title":"How do live birth and cumulative live birth rate in IVF cycles change with the number of oocytes retrieved?","volume":"3","author":"Zac\u00e0","year":"2017","journal-title":"EC Gynaecol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221002910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221002910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:33:27Z","timestamp":1758011607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028221002910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0015028221002910"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.04.006","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in\u00a0vitro fertilization cycles","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92021 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}