{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:59:45Z","timestamp":1789340385828,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.fertnstert.2021.04.030","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T10:10:15Z","timestamp":1621851015000},"page":"757-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Changing stimulation protocol on repeat conventional ovarian stimulation cycles does not lead to improved laboratory outcomes"],"prefix":"10.1016","volume":"116","author":[{"given":"Kaitlyn","family":"Wald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-8995","authenticated-orcid":false,"given":"Eduardo","family":"Hariton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrine R.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan A.","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni G.","family":"Jaswa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle I.","family":"Cedars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2021.04.030_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fertnstert.2018.06.005","article-title":"Forty years of IVF","volume":"110","author":"Niederberger","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hox018","article-title":"How much variation in oocyte yield after controlled ovarian stimulation can be explained? A multilevel modelling study","volume":"2017","author":"Rustamov","year":"2017","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib3","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.fertnstert.2008.10.042","article-title":"A prospective, comparative analysis of anti-Mullerian hormone, inhibin-B, and three-dimensional ultrasound determinants of ovarian reserve in the prediction of poor response to controlled ovarian stimulation","volume":"93","author":"Jayaprakasan","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib4","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0015-0282(00)00708-1","article-title":"Basal antral follicle number and mean ovarian diameter predict cycle cancellation and ovarian responsiveness in assisted reproductive technology cycles","volume":"74","author":"Frattarelli","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0015-0282(01)02893-X","article-title":"Differentiating clinical profiles: predicting good responders, poor responders, and hyperresponders","volume":"76","author":"Kligman","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib6","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1001\/jama.2015.17296","article-title":"Live-birth rate associated with repeat in\u00a0vitro fertilization treatment cycles","volume":"314","author":"Smith","year":"2015","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-0035-1546424","article-title":"Best practices for controlled ovarian stimulation in in\u00a0vitro fertilization","volume":"33","author":"Jungheim","year":"2015","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/humupd\/dmt037","article-title":"Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice","volume":"20","author":"La Marca","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.fertnstert.2013.10.049","article-title":"Change in oocyte yield in repeated in\u00a0vitro fertilization cycles: effect of ovarian reserve","volume":"101","author":"Eppsteiner","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib10","first-page":"556","article-title":"Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women: secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols","volume":"32","author":"Toftager","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1210\/er.2005-0015","article-title":"The science behind 25 years of ovarian stimulation for in\u00a0vitro fertilization","volume":"27","author":"Macklon","year":"2006","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/REP-09-0187","article-title":"The impact of ovarian stimulation for IVF on the developing embryo","volume":"139","author":"Santos","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib14","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/humrep\/del484","article-title":"Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial","volume":"22","author":"Baart","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.fertnstert.2005.03.045","article-title":"Chromosome 21 mosaic human preimplantation embryos predominantly arise from diploid conceptions","volume":"84","author":"Katz-Jaffe","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib16","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/humrep\/12.4.780","article-title":"Treatment-related chromosome abnormalities in human embryos","volume":"12","author":"Munne","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib17","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/humrep\/deaa028","article-title":"No effect of ovarian stimulation and oocyte yield on euploidy and live birth rates: an analysis of 12 298 trophectoderm biopsies","volume":"35","author":"Irani","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib18","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1136\/bmj.308.6942.1499","article-title":"Regression towards the mean","volume":"308","author":"Bland","year":"1994","journal-title":"Br Med J"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib19","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1210\/jc.2009-0262","article-title":"Ovarian luteinizing hormone priming preceding follicle-stimulating hormone stimulation: clinical and endocrine effects in women with long-term hypogonadotropic hypogonadism","volume":"94","author":"Balasch","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib20","first-page":"283","article-title":"A priming effect of gonadotrophin releasing hormone on luteinizing hormone secretion in the boar","volume":"46","author":"Liptrap","year":"1982","journal-title":"Can J Comp Med"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib21","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/humrep\/dex299","article-title":"High gonadotropin dosage does not affect euploidy and pregnancy rates in IVF PGS cycles with single embryo transfer","volume":"32","author":"Barash","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib22","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.fertnstert.2020.09.158","article-title":"Individualized ovarian stimulation for in\u00a0vitro fertilization: a multicenter, open label, exploratory study with a mixed protocol of follitropin delta and highly purified human menopausal gonadotropin","volume":"115","author":"Bissonnette","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib23","first-page":"1","article-title":"Effect of ovarian stimulation on embryo aneuploidy and mosaicism rate","author":"Cascales","year":"2021","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2019.103707","article-title":"Controlled ovarian hyperstimulation (COH) parameters associated with euploidy rates in donor oocytes","volume":"62","author":"McCulloh","year":"2019","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.fertnstert.2021.04.030_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/humupd\/dmn053","article-title":"The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis","volume":"15","author":"Verberg","year":"2009","journal-title":"Hum Reprod Update"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221003241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221003241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:32:14Z","timestamp":1758011534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028221003241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0015028221003241"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.04.030","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changing stimulation protocol on repeat conventional ovarian stimulation cycles does not lead to improved laboratory outcomes","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92021 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}