{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:06:38Z","timestamp":1792206398776,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.fertnstert.2021.06.049","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T01:34:47Z","timestamp":1628386487000},"page":"1483-1490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment"],"prefix":"10.1016","volume":"116","author":[{"given":"Sladjana Mali\u0107","family":"Von\u010dina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-5199","authenticated-orcid":false,"given":"Amelie","family":"Stenqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Bungum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Schyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Giwercman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2021.06.049_bib1","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/humrep\/dex264","article-title":"Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE","volume":"32","author":"Calhaz-Jorge","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-4755-11-37","article-title":"Demographic relevancy of increased use of assisted reproduction in European countries","volume":"11","author":"Kocourkova","year":"2014","journal-title":"Reprod Health"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib3","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1080\/00016340802460305","article-title":"Absence from work and emotional stress in women undergoing IVF or ICSI: an analysis of IVF-related absence from work in women and the contribution of general and emotional factors","volume":"87","author":"Bouwmans","year":"2008","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.fertnstert.2015.10.032","article-title":"Costs of achieving live birth from assisted reproductive technology: a comparison of sequential single and double embryo transfer approaches","volume":"105","author":"Crawford","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib5","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/humrep\/des016","article-title":"Understanding the perceptions of and emotional barriers to infertility treatment: a survey in four European countries","volume":"27","author":"Domar","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib6","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/humupd\/dms031","article-title":"Why do patients discontinue fertility treatment? A systematic review of reasons and predictors of discontinuation in fertility treatment","volume":"18","author":"Gameiro","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib7","first-page":"2703","article-title":"Cumulative live birth rate: time for a consensus?","volume":"30","author":"Maheshwari","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.rbmo.2014.10.018","article-title":"The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta-analysis","volume":"30","author":"Osman","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1055\/s-0035-1546825","article-title":"To ICSI or not to ICSI","volume":"33","author":"Palermo","year":"2015","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib10","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1093\/humrep\/dex293","article-title":"Cumulative live birth rates following miscarriage in an initial complete cycle of IVF: a retrospective cohort study of 112 549 women","volume":"32","author":"Cameron","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib11","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S1701-2163(15)30312-1","article-title":"An integrated approach to male-factor subfertility: bridging the gap between fertility specialists trained in urology and gynaecology","volume":"37","author":"Hughes","year":"2015","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejogrb.2017.12.016","article-title":"An ART score to note objectively the quality of an ART procedure","volume":"221","author":"Labrune","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib13","first-page":"119","article-title":"The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age","volume":"32","author":"Tannus","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib14","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/0272989X14535984","article-title":"Predictive modeling of implantation outcome in an in\u00a0vitro fertilization setting: an application of machine learning methods","volume":"35","author":"Uyar","year":"2015","journal-title":"Med Decis Making"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165125","article-title":"Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis","volume":"11","author":"Cissen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib16","doi-asserted-by":"crossref","first-page":"S618","DOI":"10.21037\/tau.2017.06.10","article-title":"Sperm DNA fragmentation testing as a diagnostic and prognostic parameter of couple infertility","volume":"6","author":"Ferlin","year":"2017","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10815-006-9066-9","article-title":"Correlation of sperm DNA damage with IVF and ICSI outcomes: a systematic review and meta-analysis","volume":"23","author":"Li","year":"2006","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib18","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1093\/humrep\/deu228","article-title":"Paternal influence of sperm DNA integrity on early embryonic development","volume":"29","author":"Simon","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3109\/19396368.2010.515704","article-title":"Are sperm chromatin and DNA defects relevant in the clinic?","volume":"57","author":"Zini","year":"2011","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/andr.12153","article-title":"Sperm chromatin structure assay in prediction of in\u00a0vitro fertilization outcome","volume":"4","author":"Oleszczuk","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib21","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/humrep\/dey118","article-title":"ICSI does not increase the cumulative live birth rate in non-male factor infertility","volume":"33","author":"Li","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib22","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2012.12.049","article-title":"The clinical utility of sperm DNA integrity testing: a guideline","volume":"99","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib23","doi-asserted-by":"crossref","first-page":"S586","DOI":"10.21037\/tau.2017.03.49","article-title":"Guidelines on sperm DNA fragmentation testing","volume":"6","author":"Vandekerckhove","year":"2017","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib24","first-page":"556","article-title":"Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women: secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols","volume":"32","author":"Toftager","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00001703-199906000-00013","article-title":"Culture and transfer of human blastocysts","volume":"11","author":"Gardner","year":"1999","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib26","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.fertnstert.2012.01.093","article-title":"Ovarian response to controlled ovarian hyperstimulation in cancer patients is diminished even before oncological treatment","volume":"97","author":"Domingo","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib27","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/humrep\/deh280","article-title":"The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI","volume":"19","author":"Bungum","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib28","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/humrep\/14.4.1039","article-title":"Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic","volume":"14","author":"Evenson","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib29","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1111\/j.1365-2605.2009.00995.x","article-title":"Sperm chromatin structure assay as an independent predictor of fertility in\u00a0vivo: a case-control study","volume":"33","author":"Giwercman","year":"2010","journal-title":"Int J Androl"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/humrep\/del326","article-title":"Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome","volume":"22","author":"Bungum","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3109\/14647273.2012.720051","article-title":"Who needs ICSI? A nationwide UK survey on ICSI use","volume":"15","author":"Jones","year":"2012","journal-title":"Hum Fertil (Camb)"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0015-0282(01)03217-4","article-title":"Cumulative probability of live birth after three in\u00a0vitro fertilization\/intracytoplasmic sperm injection cycles","volume":"77","author":"Olivius","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib33","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1001\/jama.2015.17296","article-title":"Live-birth rate associated with repeat in\u00a0vitro fertilization treatment cycles","volume":"314","author":"Smith","year":"2015","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/humrep\/dez017","article-title":"Are interventions in reproductive medicine assessed for plausible and clinically relevant effects? A systematic review of power and precision in trials and meta-analyses","volume":"34","author":"Stocking","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.fertnstert.2004.11.003","article-title":"How do infertile couples choose their IVF centers? An Internet-based survey","volume":"83","author":"Marcus","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.06.049_bib36","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1093\/humrep\/der328","article-title":"Intra-individual variation of the sperm chromatin structure assay DNA fragmentation index in men from infertile couples","volume":"26","author":"Oleszczuk","year":"2011","journal-title":"Hum Reprod"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221005628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221005628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:35:39Z","timestamp":1758011739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028221005628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0015028221005628"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.06.049","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.06.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92021 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}