{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:42:29Z","timestamp":1783489349427,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.fertnstert.2021.07.1200","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:58:07Z","timestamp":1630025887000},"page":"625-629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Iatrogenic effects of radical cancer surgery on male fertility"],"prefix":"10.1016","volume":"116","author":[{"given":"Zhenyue","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2021.07.1200_bib1","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1200\/JCO.2002.07.175","article-title":"Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors","volume":"20","author":"Schover","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib2","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1200\/JCO.2018.78.1914","article-title":"Fertility preservation in patients with cancer: ASCO Clinical Practice Guideline Update","volume":"36","author":"Oktay","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.eururo.2017.06.035","article-title":"Quality of life outcomes after primary treatment for clinically localised prostate cancer: a systematic review","volume":"72","author":"Lardas","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ucl.2017.12.008","article-title":"Quality of life after radical cystectomy","volume":"45","author":"Tyson","year":"2018","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib6","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.urology.2015.07.010","article-title":"Review of the different treatments and management for prostate cancer and fertility","volume":"86","author":"Tran","year":"2015","journal-title":"Urology"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.fertnstert.2013.03.049","article-title":"Sperm banking is of key importance in patients with prostate cancer","volume":"100","author":"Salonia","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.urology.2006.09.036","article-title":"Fertility issues for men with newly diagnosed prostate cancer","volume":"69","author":"Knoester","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib9","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0022-5347(05)68794-0","article-title":"Orthotopic urinary diversion with preservation of erectile and ejaculatory function in men requiring radical cystectomy for nonurothelial malignancy: a new technique","volume":"161","author":"Spitz","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00005392-200101000-00013","article-title":"Nerve and seminal sparing radical cystectomy with orthotopic urinary diversion for select patients with superficial bladder cancer: an innovative surgical approach","volume":"165","author":"Colombo","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2164\/jandrol.05074","article-title":"Erection- and ejaculation-preserving cystectomy with orthotopic urinary diversion: is it feasible?","volume":"27","author":"Girgin","year":"2006","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib12","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0302-2838(03)00099-X","article-title":"Sexuality preserving cystectomy and neobladder (SPCN): functional results of a neobladder anastomosed to the prostate","volume":"43","author":"Meinhardt","year":"2003","journal-title":"Eur Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/01.ju.0000132130.64727.b6","article-title":"Seminal sparing cystectomy and ileocapsuloplasty: long-term followup results","volume":"172","author":"Muto","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib14","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/S0022-5347(05)64157-2","article-title":"Cystectomy with prostate sparing for bladder cancer in 100 patients: 10-year experience","volume":"168","author":"Vallancien","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1442-2042.2007.01607.x","article-title":"Radical cystectomy with preservation of sexual function and fertility in patients with transitional cell carcinoma of the bladder: new technique","volume":"14","author":"Salem","year":"2007","journal-title":"Int J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ucl.2015.04.005","article-title":"The evolution and technique of nerve-sparing retroperitoneal lymphadenectomy","volume":"42","author":"Masterson","year":"2015","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-5347(17)36046-9","article-title":"Retroperitoneal lymphadenectomy for clinical stage A testis cancer (1965-1989): modifications of technique and impact on ejaculation","volume":"149","author":"Donohue","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib18","first-page":"130","article-title":"Summary of distribution of retroperitoneal lymph node metastases in testicular germinal tumors (by Biswamay Ray, MD, Steven I. Hajdu, MD, and Willet F. Whitmore, Jr, MD). 1974","volume":"15","author":"Ray","year":"1997","journal-title":"Semin Urol Oncol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib19","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0022-5347(17)39681-7","article-title":"Clinical stage 1 testicular cancer: the role of modified retroperitoneal lymphadenectomy","volume":"144","author":"Richie","year":"1990","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib20","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/j.juro.2010.06.146","article-title":"Ejaculatory status and fertility rates after primary retroperitoneal lymph node dissection","volume":"184","author":"Beck","year":"2010","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib21","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0022-5347(17)42869-2","article-title":"Retroperitoneal lymphadenectomy for testis tumor with nerve sparing for ejaculation","volume":"139","author":"Jewett","year":"1988","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fsurg.2018.00080","article-title":"Preservation of ejaculatory function after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) in patients with testicular cancer: template vs. bilateral resection","volume":"5","author":"Hiester","year":"2018","journal-title":"Front Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.eururo.2008.09.027","article-title":"Postchemotherapy retroperitoneal lymph node dissection in advanced testicular cancer: radical or modified template resection","volume":"55","author":"Heidenreich","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.urology.2008.08.501","article-title":"Preservation of ejaculation in patients undergoing nerve-sparing postchemotherapy retroperitoneal lymph node dissection for metastatic testicular cancer","volume":"73","author":"Pettus","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib25","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/cncr.22898","article-title":"Is full bilateral retroperitoneal lymph node dissection always necessary for postchemotherapy residual tumor?","volume":"110","author":"Beck","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/bju.13844","article-title":"Modified retroperitoneal lymph node dissection for post-chemotherapy residual tumour: a long-term update","volume":"120","author":"Cho","year":"2017","journal-title":"BJU Int"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib27","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1200\/JCO.2007.11.2078","article-title":"Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modified postchemotherapy retroperitoneal lymph node dissection","volume":"25","author":"Carver","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1055\/s-0038-1677027","article-title":"Overlooked long-term complications of colorectal surgery","volume":"32","author":"Giglia","year":"2019","journal-title":"Clin Colon Rectal Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib29","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1046\/j.1365-2168.2000.01542.x","article-title":"Anatomy of Denonvilliers' fascia and pelvic nerves, impotence, and implications for the colorectal surgeon","volume":"87","author":"Lindsey","year":"2000","journal-title":"Br J Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib30","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1001\/archsurg.1992.01420120030005","article-title":"Potency, cure, and local control in the operative treatment of rectal cancer","volume":"127","author":"Enker","year":"1992","journal-title":"Arch Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib31","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1007\/BF02081416","article-title":"Male sexual function after autonomic nerve-preserving operation for rectal cancer","volume":"39","author":"Masui","year":"1996","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib32","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1007\/s10350-004-6388-5","article-title":"Assessment of sexual and voiding function after total mesorectal excision with pelvic autonomic nerve preservation in males with rectal cancer","volume":"45","author":"Kim","year":"2002","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib33","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s00268-005-0050-9","article-title":"Impact of autonomic nerve preservation and lateral node dissection on male urogenital function after total mesorectal excision for lower rectal cancer","volume":"30","author":"Kyo","year":"2006","journal-title":"World J Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib34","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1463-1318.2008.01642.x","article-title":"Preservation of sexual and bladder function after laparoscopic rectal surgery","volume":"11","author":"Jones","year":"2009","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib35","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1245\/s10434-006-9052-6","article-title":"Laparoscopic pelvic autonomic nerve-preserving surgery for patients with lower rectal cancer after chemoradiation therapy","volume":"14","author":"Liang","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib36","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/bjs.4989","article-title":"Bladder and sexual function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique","volume":"92","author":"Jayne","year":"2005","journal-title":"Br J Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib37","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/bjs.9550","article-title":"Patient-reported genitourinary dysfunction after laparoscopic and open rectal cancer surgery in a randomized trial (COLOR II)","volume":"101","author":"Andersson","year":"2014","journal-title":"Br J Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib38","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/DCR.0000000000000688","article-title":"Adoption of robotic technology for treating colorectal cancer","volume":"59","author":"Schootman","year":"2016","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11701-012-0383-y","article-title":"Robot-assisted low anterior resection in fifty-three consecutive patients: an Indian experience","volume":"7","author":"Kenawadekar","year":"2013","journal-title":"J Robot Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib40","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/SLA.0b013e318269d03b","article-title":"Impact of robotic surgery on sexual and urinary functions after fully robotic nerve-sparing total mesorectal excision for rectal cancer","volume":"257","author":"Luca","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/SLA.0000000000002321","article-title":"Robot-assisted versus laparoscopic surgery for rectal cancer: a phase II open label prospective randomized controlled trial","volume":"267","author":"Kim","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0959-8049(98)00357-8","article-title":"The construction and testing of the EORTC colorectal cancer-specific quality of life questionnaire module (QLQ-CR38). European Organization for Research and Treatment of Cancer Study Group on Quality of Life","volume":"35","author":"Sprangers","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.wneu.2019.07.023","article-title":"Evolution of the anterior approach in lumbar spine fusion","volume":"131","author":"Bassani","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib44","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.spinee.2015.02.040","article-title":"Anterior lumbar spine surgery: a systematic review and meta-analysis of associated complications","volume":"15","author":"Bateman","year":"2015","journal-title":"Spine J"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib45","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/01.BRS.0000062965.47779.EB","article-title":"Retrograde ejaculation after anterior lumbar interbody fusion: transperitoneal versus retroperitoneal exposure","volume":"28","author":"Sasso","year":"2003","journal-title":"Spine"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib46","unstructured":"United States Food and Drug Administration. Premarket Approval (PMA). Infuse bone graft\/lt-cage lumbar tapered fusion device. Available at: https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfpma\/pma.cfm?id=P000058. Accessed July 5, 2021."},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib47","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.spinee.2013.08.060","article-title":"Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery","volume":"14","author":"Tannoury","year":"2014","journal-title":"Spine J"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.spinee.2011.04.023","article-title":"A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned","volume":"11","author":"Carragee","year":"2011","journal-title":"Spine J"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib49","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.spinee.2011.02.013","article-title":"Retrograde ejaculation after anterior lumbar interbody fusion using rhBMP-2: a cohort controlled study","volume":"11","author":"Carragee","year":"2011","journal-title":"Spine J"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib50","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.spinee.2012.09.040","article-title":"Retrograde ejaculation after anterior lumbar interbody fusion with and without bone morphogenetic protein-2 augmentation: a 10-year cohort controlled study","volume":"12","author":"Comer","year":"2012","journal-title":"Spine J"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3171\/2012.10.SPINE11908","article-title":"Retrograde ejaculation following single-level anterior lumbar surgery with or without recombinant human bone morphogenetic protein-2 in 5 randomized controlled trials: clinical article","volume":"18","author":"Burkus","year":"2013","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib52","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/BRS.0b013e31828bf36a","article-title":"Quantitative assessment of retrograde ejaculation using semen analysis, comparison with a standardized qualitative questionnaire, and investigating the impact of rhBMP-2","volume":"38","author":"Tepper","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.fertnstert.2021.07.1200_bib53","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1097\/BRS.0b013e31825752bc","article-title":"Retrograde ejaculation after anterior lumbar spine surgery","volume":"37","author":"Lindley","year":"2012","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221017994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221017994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:33:10Z","timestamp":1758011590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028221017994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0015028221017994"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.07.1200","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iatrogenic effects of radical cancer surgery on male fertility","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.07.1200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92021 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}