{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:17:43Z","timestamp":1791908263569,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370681"],"award-info":[{"award-number":["81370681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["IRT0935"],"award-info":[{"award-number":["IRT0935"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018621","name":"Program for Changjiang Scholars and Innovative Research Team in University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.fertnstert.2021.07.1203","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T06:55:27Z","timestamp":1629615327000},"page":"1641-1650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome"],"prefix":"10.1016","volume":"116","author":[{"given":"Yuan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2021.07.1203_bib1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/humupd\/dmy022","article-title":"Understanding variation in prevalence estimates of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"24","author":"Skiba","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/humupd\/dmy007","article-title":"Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression","volume":"24","author":"Kakoly","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2017.09.016","article-title":"Polycystic ovarian syndrome (PCOS): long-term metabolic consequences","volume":"86","author":"Anagnostis","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/cen.13171","article-title":"Oxidative stress status in Chinese women with different clinical phenotypes of polycystic ovary syndrome","volume":"86","author":"Zhang","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of pcos as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr Rev"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cca.2019.09.010","article-title":"Sex hormone-binding globulin and polycystic ovary syndrome","volume":"499","author":"Zhu","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/MED.0b013e328353732f","article-title":"Evolving utility of sex hormone-binding globulin measurements in clinical medicine","volume":"19","author":"Hammond","year":"2012","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib9","doi-asserted-by":"crossref","first-page":"34105","DOI":"10.1074\/jbc.273.51.34105","article-title":"Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter","volume":"273","author":"J\u00e4nne","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib10","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1210\/en.2008-1289","article-title":"Peroxisome-proliferator receptor gamma represses hepatic sex hormone-binding globulin expression","volume":"150","author":"Selva","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib11","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1210\/en.2014-1072","article-title":"Adiponectin upregulates SHBG production: molecular mechanisms and potential implications","volume":"155","author":"Sim\u00f3","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/db11-0727","article-title":"Potential role of tumor necrosis factor-alpha in downregulating sex hormone-binding globulin","volume":"61","author":"Sim\u00f3","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib13","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1210\/jc.2019-00987","article-title":"Oxidative stress in response to saturated fat ingestion is linked to insulin resistance and hyperandrogenism in\u00a0polycystic ovary syndrome","volume":"104","author":"Gonz\u00e1lez","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/humupd\/dms059","article-title":"Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis","volume":"19","author":"Murri","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib15","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.fertnstert.2015.02.024","article-title":"Antioxidant properties of high-density lipoproteins are impaired in women with polycystic ovary syndrome","volume":"103","author":"Zhang","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3389\/fendo.2019.00771","article-title":"Association of GPx1 P198L and CAT C-262T genetic variations with polycystic ovary syndrome in Chinese women","volume":"10","author":"Sun","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib18","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1093\/humrep\/des191","article-title":"Apolipoprotein A-I and B levels, dyslipidemia and metabolic syndrome in south-west Chinese women with PCOS","volume":"27","author":"Zhang","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/humrep\/der396","article-title":"Consensus on women's health aspects of polycystic ovary syndrome (PCOS)","volume":"27","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib20","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s40618-018-0999-5","article-title":"Association of SOD2 A16V and PON2 S311C polymorphisms with polycystic ovary syndrome in Chinese women","volume":"42","author":"Liu","year":"2019","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.rbmo.2011.10.010","article-title":"Apolipoprotein E-containing HDL-associated platelet-activating factor acetylhydrolase activities and malondialdehyde concentrations in patients with PCOS","volume":"24","author":"Fan","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.fertnstert.2009.03.005","article-title":"Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?","volume":"94","author":"Huang","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.atherosclerosis.2005.07.029","article-title":"Modulating effects of cholesterol feeding and simvastatin treatment on platelet-activating factor acetylhydrolase activity and lysophosphatidylcholine concentration","volume":"186","author":"Zhang","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.atherosclerosis.2007.08.026","article-title":"A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein","volume":"197","author":"Gerry","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1530\/EC-20-0141","article-title":"Longitudinal associations between sex hormone-binding globulin and insulin resistance","volume":"9","author":"Ottarsdottir","year":"2020","journal-title":"Endocr Connect"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib26","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1056\/NEJMc0910143","article-title":"Sex hormone-binding globulin and risk of type 2 diabetes","volume":"361","author":"Stefan","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/ars.2017.7052","article-title":"Lipoproteins and cardiovascular redox signaling: role in atherosclerosis and coronary disease","volume":"29","author":"Haghikia","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.freeradbiomed.2008.10.024","article-title":"Activation of transcription factors and gene expression by oxidized low-density lipoprotein","volume":"46","author":"Mazi\u00e8re","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.trsl.2008.12.005","article-title":"Oxidized phospholipids in control of inflammation and endothelial barrier","volume":"153","author":"Fu","year":"2009","journal-title":"Transl Res"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/01.mol.0000180167.15820.ae","article-title":"Nuclear factor kappa B signaling in macrophage function and atherogenesis","volume":"16","author":"Xanthoulea","year":"2005","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1210\/jc.2014-2419","article-title":"Up-regulated expression of WNT5a increases inflammation and oxidative stress via PI3K\/AKT\/NF-\u03baB signaling in the granulosa cells of PCOS patients","volume":"100","author":"Zhao","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.steroids.2011.12.003","article-title":"Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction","volume":"77","author":"Gonz\u00e1lez","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib33","doi-asserted-by":"crossref","first-page":"e13438","DOI":"10.1111\/eci.13438","article-title":"Myeloperoxidase and CYBA genetic variants in polycystic ovary syndrome","volume":"51","author":"Ma","year":"2021","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib34","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1530\/EJE-11-0986","article-title":"Evidence for association between paraoxonase 1 gene polymorphisms and polycystic ovarian syndrome in southwest Chinese women","volume":"166","author":"Wang","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib35","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/humrep\/deq047","article-title":"Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome","volume":"25","author":"Fan","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib36","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1093\/humrep\/des320","article-title":"Hyperglycemia-induced oxidative stress is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome","volume":"27","author":"Gonz\u00e1lez","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib37","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1210\/jc.2018-02747","article-title":"Sex differences in effects of obesity on reproductive hormones and glucose metabolism in early puberty","volume":"104","author":"Nokoff","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1467-789X.2012.01053.x","article-title":"The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis","volume":"14","author":"Lim","year":"2013","journal-title":"Obes Rev"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib39","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1210\/me.2007-0531","article-title":"Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs","volume":"23","author":"Xie","year":"2009","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mce.2009.09.020","article-title":"Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome","volume":"316","author":"Pugeat","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.fertnstert.2021.07.1203_bib41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/humupd\/dmp006","article-title":"Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis","volume":"15","author":"Toulis","year":"2009","journal-title":"Hum Reprod Update"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221018069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221018069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:36:27Z","timestamp":1758011787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028221018069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0015028221018069"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.07.1203","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.07.1203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92021 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}