{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:28:31Z","timestamp":1787225311922,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.fertnstert.2021.12.032","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T10:24:58Z","timestamp":1641032698000},"page":"771-780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Undetectable viral RNA in follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2\u2013positive women"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-2996","authenticated-orcid":false,"given":"Liese","family":"Boudry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa","family":"Essahib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Mateizel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Van de Velde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"De Geyter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Pi\u00e9rard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Waelput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Uvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Tournaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"De Brucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2021.12.032_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib2","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","year":"2020","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41586-020-2271-3","article-title":"Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals","volume":"582","author":"Liu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.fertnstert.2021.01.016","article-title":"Infection precautions for severe acute respiratory syndrome coronavirus 2 in assisted reproduction centers: dodging an invisible bullet","volume":"115","author":"Sparks","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2020.558144","article-title":"Pregnancy and breastfeeding during COVID-19 pandemic: a systematic review of published pregnancy cases","volume":"8","author":"Rodrigues","year":"2020","journal-title":"Front Public Health"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib6","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.fertnstert.2020.12.032","article-title":"The effects of COVID-19 on pregnancy and implications for reproductive medicine","volume":"115","author":"Joseph","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajog.2020.07.049","article-title":"Vertical transmission of COVID-19: a systematic review and meta-analysis","volume":"224","author":"Kotlyar","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/0265673021000039628","article-title":"Effects of heat on embryos and fetuses","volume":"19","author":"Edwards","year":"2003","journal-title":"Int J Hyperthermia"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/(SICI)1096-9926(199811)58:5<209::AID-TERA8>3.0.CO;2-Q","article-title":"Teratogen update: gestational effects of maternal hyperthermia due to febrile illnesses and resultant patterns of defects in humans","volume":"58","author":"Graham","year":"1998","journal-title":"Teratology"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib10","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/humrep\/der037","article-title":"The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting","volume":"26","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/humrep\/deq374","article-title":"Outcome of closed blastocyst vitrification in relation to blastocyst quality: evaluation of 759 warming cycles in a single-embryo transfer policy","volume":"26","author":"Van Landuyt","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib12","first-page":"1843","article-title":"Detection of SARS-CoV-2 in different types of clinical specimens","volume":"323","author":"Wang","year":"2020","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s10815-015-0541-z","article-title":"Reduced blastocyst formation in reduced culture volume","volume":"32","author":"De Munck","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib14","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/humrep\/dew045","article-title":"What is the optimal duration of progesterone administration before transferring a vitrified-warmed cleavage stage embryo? A randomized controlled trial","volume":"31","author":"van de Vijver","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib15","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/humrep\/dew263","article-title":"Frozen\u2013thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues","volume":"31","author":"Montagut","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib16","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/humrep\/dep343","article-title":"The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary on ART terminology, 2009","volume":"24","author":"Zegers-Hochschild","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib17","first-page":"1162","article-title":"SARS-CoV-2 entry factors: ACE2 and TMPRSS2 are expressed in peri-implantation embryos and the maternal\u2013fetal interface","volume":"6","author":"Chen","year":"2020","journal-title":"Engineering (Beijing)"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib19","first-page":"33","article-title":"Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection","volume":"2","author":"Rajput","year":"2021","journal-title":"F S Sci"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib20","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200162","article-title":"Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester","volume":"10","author":"Weatherbee","year":"2020","journal-title":"Open Biol"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41392-021-00558-8","article-title":"Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-020-00426-x","article-title":"CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells","volume":"5","author":"Wang","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib23","article-title":"Human pre-implantation embryos are permissive to SARS-CoV-2 entry","author":"Montano","year":"2021","journal-title":"Biorxiv"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib24","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1007\/s43032-021-00502-9","article-title":"Failure to detect viral RNA in follicular fluid aspirates from a SARS-CoV-2-positive woman","volume":"28","author":"Demirel","year":"2021","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib25","first-page":"deab255","article-title":"Risk of contamination of semen, vaginal secretions, follicular fluid and ovarian medulla with SARS-CoV-2 in patients undergoing ART","author":"Kteily","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib26","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/j.fertnstert.2020.08.249","article-title":"Cell-level expression of sars-cov-2 cell entry factors in human endometrium during the preconception period","volume":"114","author":"Vilella","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2021.12.032_bib27","doi-asserted-by":"crossref","first-page":"m2519","DOI":"10.1136\/bmj.m2519","article-title":"Freeze-all versus fresh blastocyst transfer strategy during in\u00a0vitro fertilisation in women with regular menstrual cycles: multicentre randomised controlled trial","volume":"370","author":"Stormlund","year":"2020","journal-title":"Br Med J"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221023256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028221023256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:33:03Z","timestamp":1758011583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028221023256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0015028221023256"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.12.032","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Undetectable viral RNA in follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2\u2013positive women","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2021.12.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92022 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine","name":"copyright","label":"Copyright"}]}}