{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:09:25Z","timestamp":1788588565701,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100020196","name":"Shandong Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["202103003"],"award-info":[{"award-number":["202103003"]}],"id":[{"id":"10.13039\/501100020196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171692"],"award-info":[{"award-number":["82171692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2020RU001"],"award-info":[{"award-number":["2020RU001"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH065"],"award-info":[{"award-number":["ZR2020MH065"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700700"],"award-info":[{"award-number":["2021YFC2700700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.fertnstert.2022.09.004","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T07:25:36Z","timestamp":1666423536000},"page":"1117-1126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations of maternal obesity, frozen embryos, and offspring adverse cardiometabolic alterations"],"prefix":"10.1016","volume":"118","author":[{"given":"Bingqian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-9169","authenticated-orcid":false,"given":"Linlin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2022.09.004_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1001\/jamapsychiatry.2021.3647","article-title":"Long-term follow-up of psychiatric disorders in children and adolescents conceived by assisted reproductive techniques in Sweden","volume":"79","author":"Wang","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib2","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3390\/nu7031378","article-title":"The periconceptional environment and cardiovascular disease: does in\u00a0vitro embryo culture and transfer influence cardiovascular development and health?","volume":"7","author":"Padhee","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.32602","article-title":"Assessment of cardiovascular health of children ages 6 to 10 years conceived by assisted reproductive technology","volume":"4","author":"Cui","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1001\/jama.2014.14488","article-title":"Safety of assisted reproductive technology in the United States, 2000-2011","volume":"313","author":"Kawwass","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib5","first-page":"359","volume":"14","author":"Lu","year":"2013"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/humupd\/dmz001","article-title":"The health of children conceived by ART: 'the chicken or the egg?","volume":"25","author":"Berntsen","year":"2019","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.fertnstert.2017.01.017","article-title":"Obesity and female infertility: potential mediators of obesity's impact","volume":"107","author":"Broughton","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/humupd\/dmz011","article-title":"Female obesity is negatively associated with live birth rate following IVF: a systematic review and meta-analysis","volume":"25","author":"Sermondade","year":"2019","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib9","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10654-015-0085-7","article-title":"Maternal obesity during pregnancy and cardiovascular development and disease in the offspring","volume":"30","author":"Gaillard","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib10","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S2213-8587(20)30151-0","article-title":"Maternal obesity and risk of cardiovascular diseases in offspring: a population-based cohort and sibling-controlled study","volume":"8","author":"Razaz","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/592408","article-title":"Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models","volume":"2011","author":"Li","year":"2011","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2014.05.027","article-title":"Cryopreservation of human embryos and its contribution to in\u00a0vitro fertilization success rates","volume":"102","author":"Wong","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/humupd\/dmy033","article-title":"Fresh versus elective frozen embryo transfer in IVF\/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes","volume":"25","author":"Roque","year":"2019","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib14","doi-asserted-by":"crossref","first-page":"m2519","DOI":"10.1136\/bmj.m2519","article-title":"Freeze-all versus fresh blastocyst transfer strategy during in\u00a0vitro fertilisation in women with regular menstrual cycles: multicentre randomised controlled trial","volume":"370","author":"Stormlund","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib15","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(18)32843-5","article-title":"Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial","volume":"393","author":"Wei","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus frozen embryos for infertility in the polycystic ovary syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humupd\/dmx031","article-title":"Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer?","volume":"24","author":"Maheshwari","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib18","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/humrep\/deab008","article-title":"Effect of parental and ART treatment characteristics on perinatal outcomes","volume":"36","author":"Pontesilli","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib19","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/humrep\/deaa304","article-title":"High birth weight and large-for-gestational-age in singletons born after frozen compared with fresh embryo transfer, by gestational week: a Nordic register study from the CoNARTaS group","volume":"36","author":"Terho","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003683","article-title":"Separating parental and treatment contributions to perinatal health after fresh and frozen embryo transfer in assisted reproduction: a cohort study with within-sibship analysis","volume":"18","author":"Westvik-Johari","year":"2021","journal-title":"PLoS Med"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib21","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.fertnstert.2017.01.021","article-title":"Perinatal outcomes in children born after fresh or frozen embryo transfer: a Catalan cohort study based on 14,262 newborns","volume":"107","author":"Vidal","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib22","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(18)30312-X","article-title":"Origins of lifetime health around the time of conception: causes and consequences","volume":"391","author":"Fleming","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","year":"2004","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1016\/j.fertnstert.2022.09.004_bib24","first-page":"1","article-title":"The guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"17","author":"Chen","year":"2004","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib25","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1631\/jzus.B1600341","article-title":"Dietary Guidelines for Chinese Residents (2016): comments and comparisons","volume":"17","author":"Wang","year":"2016","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib27","series-title":"Composition 2004","author":"Yang","year":"2005"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2840-7-17","article-title":"On the use of a continuous metabolic syndrome score in pediatric research","volume":"7","author":"Eisenmann","year":"2008","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/obr.12334","article-title":"Predicting adult obesity from childhood obesity: a systematic review and meta-analysis","volume":"17","author":"Simmonds","year":"2016","journal-title":"Obes Rev"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib31","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1161\/CIRCULATIONAHA.113.002428","article-title":"Assisted reproductive technologies are associated with cardiovascular remodeling in utero that persists postnatally","volume":"128","author":"Valenzuela-Alcaraz","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.19046","article-title":"Associations of cord blood vitamin D and preeclampsia with offspring blood pressure in childhood and adolescence","volume":"3","author":"Zhang","year":"2020","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib33","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1093\/humrep\/deaa205","article-title":"The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring","volume":"35","author":"Aljahdali","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/humrep\/det440","article-title":"Large baby syndrome in singletons born after frozen embryo transfer (FET): is it due to maternal factors or the cryotechnique?","volume":"29","author":"Pinborg","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103076","article-title":"Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring","volume":"61","author":"Chen","year":"2020","journal-title":"EBiomedicine"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib36","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/s41467-022-29540-w","article-title":"DNA methylation in newborns conceived by assisted reproductive technology","volume":"13","author":"H\u00e5berg","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2019.05.020","article-title":"Fresh versus frozen embryo transfer has no effect on childhood weight","volume":"112","author":"Ainsworth","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib38","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.fertnstert.2020.04.041","article-title":"Development of children born from freeze-only versus fresh embryo transfer: follow-up of a randomized controlled trial","volume":"114","author":"Vuong","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S2213-8587(16)30107-3","article-title":"Influence of maternal obesity on the long-term health of offspring","volume":"5","author":"Godfrey","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.fertnstert.2022.09.004_bib40","article-title":"Pregnancy, birth, and infant outcomes by maternal fertility status: the Massachusetts Outcomes Study of Assisted Reproductive Technology","volume":"217","author":"Luke","year":"2017","journal-title":"Am J Obstet Gynecol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028222014212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028222014212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:17:50Z","timestamp":1762150670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028222014212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0015028222014212"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2022.09.004","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of maternal obesity, frozen embryos, and offspring adverse cardiometabolic alterations","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2022.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92022 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}