{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:12:02Z","timestamp":1790349122726,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202040127"],"award-info":[{"award-number":["202040127"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.fertnstert.2024.01.027","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T16:44:58Z","timestamp":1706028298000},"page":"937-945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["A randomized controlled trial to compare the live birth rate of the first frozen embryo transfer following the progestin-primed ovarian stimulation protocol vs. the antagonist protocol in women with an anticipated high ovarian response"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-5395","authenticated-orcid":false,"given":"Zhi Qin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-4557","authenticated-orcid":false,"given":"Ernest Hung Yu","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2024.01.027_bib1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/humrep\/15.11.2333","article-title":"Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study","volume":"15","author":"Janssens","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/humupd\/dmx017","article-title":"GnRH antagonist versus long agonist protocols in IVF: a systematic review and meta-analysis accounting for patient type","volume":"23","author":"Lambalk","year":"2017","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib3","first-page":"211","article-title":"New stimulation regimens: endogenous and exogenous progesterone use to block the LH surge during ovarian stimulation for IVF","volume":"23","author":"Massin","year":"2017","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fertnstert.2015.03.022","article-title":"Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in\u00a0vitro fertilization","volume":"104","author":"Kuang","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/1471-0528.14622","article-title":"The pregnancy outcome of progestin-primed ovarian stimulation using 4 versus 10 mg of medroxyprogesterone acetate per day in infertile women undergoing in\u00a0vitro fertilisation: a randomised controlled trial","volume":"124","author":"Dong","year":"2017","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/humrep\/dex367","article-title":"New application of dydrogesterone as a part of a progestin-primed ovarian stimulation protocol for IVF: a randomized controlled trial including 516 first IVF\/ICSI cycles","volume":"33","author":"Yu","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus frozen embryos for infertility in the polycystic ovary syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib8","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.rbmo.2020.01.027","article-title":"Progestins versus GnRH analogues for pituitary suppression during ovarian stimulation for assisted reproductive technology: a systematic review and meta-analysis","volume":"40","author":"Alexandru","year":"2020","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib9","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/humrep\/dez034","article-title":"Medroxyprogesterone acetate versus ganirelix in oocyte donation: a randomized controlled trial","volume":"34","author":"Beguer\u00eda","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib10","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.fertnstert.2021.02.036","article-title":"Medroxyprogesterone acetate is a useful alternative to a gonadotropin-releasing hormone antagonist in oocyte donation: a randomized, controlled trial","volume":"116","author":"Giles","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1749-6632.1988.tb22263.x","article-title":"Oocyte assessment and biological performance","volume":"541","author":"Veeck","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00001703-199906000-00013","article-title":"Culture and transfer of human blastocysts","volume":"11","author":"Gardner","year":"1999","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/humrep\/dey333","article-title":"A randomized triple blind controlled trial comparing the live birth rate of IVF following brief incubation versus standard incubation of gametes","volume":"34","author":"Chen","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00404-018-4856-8","article-title":"New trial of progestin-primed ovarian stimulation using dydrogesterone versus a typical GnRH antagonist regimen in assisted reproductive technology","volume":"298","author":"Iwami","year":"2018","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib16","article-title":"Elevated progesterone on the trigger day does not impair the outcome of human menotrophins gonadotrophin and medroxyprogesterone acetate treatment cycles","volume":"6","author":"Lu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1477-7827-12-10","article-title":"Endocrine profile following stimulation with recombinant follicle stimulating hormone and luteinizing hormone versus highly purified human menopausal gonadotropin","volume":"12","author":"Requena","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s40618-016-0531-8","article-title":"Are extremely high progesterone levels still an issue in IVF?","volume":"40","author":"Vanni","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100011","article-title":"Serum progesterone elevation adversely affects cumulative live birth rate in different ovarian responders during in\u00a0vitro fertilization and embryo transfer: a large retrospective study","volume":"9","author":"Bu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib20","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/humrep\/deaa068","article-title":"Comparison of euploidy rates of blastocysts in women treated with progestins or GnRH antagonist to prevent the luteinizing hormone surge during ovarian stimulation","volume":"35","author":"La Marca","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40001-023-01000-1","article-title":"Analysis of euploidy rates in preimplantation genetic testing for aneuploidy cycles with progestin-primed versus GnRH agonist\/antagonist protocol","volume":"28","author":"Wang","year":"2023","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib22","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.rbmo.2022.03.003","article-title":"Euploidy rates among preimplantation genetic testing for aneuploidy cycles with oral dydrogesterone primed ovarian stimulation or GnRH antagonist protocol","volume":"45","author":"Yang","year":"2022","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/humupd\/dmaa040","article-title":"Progestins for pituitary suppression during ovarian stimulation for ART: a comprehensive and systematic review including meta-analyses","volume":"27","author":"Ata","year":"2021","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13048-020-00620-z","article-title":"Outcomes of fertility preservation in women with endometriosis: comparison of progestin-primed ovarian stimulation versus antagonist protocols","volume":"13","author":"Mathieu d'Argent","year":"2020","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/GCO.0000000000000362","article-title":"A universal freeze all strategy: why it is not warranted","volume":"29","author":"Ata","year":"2017","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.fertnstert.2022.06.012","article-title":"Comparison of the cumulative live birth rates after 1 in\u00a0vitro fertilization cycle in women using gonadotropin-releasing hormone antagonist protocol vs. progestin-primed ovarian stimulation: a propensity score-matched study","volume":"118","author":"Chen","year":"2022","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib27","doi-asserted-by":"crossref","first-page":"e2939","DOI":"10.1097\/MD.0000000000002939","article-title":"Controlled ovarian stimulation using medroxyprogesterone acetate and hMG in patients with polycystic ovary syndrome treated for IVF: a double-blind randomized crossover clinical trial","volume":"95","author":"Wang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib28","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.rbmo.2018.12.044","article-title":"Evaluation of the cost-effectiveness of ovulation suppression with progestins compared with GnRH analogs in assisted reproduction cycles","volume":"38","author":"Evans","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib29","article-title":"Comparison of neonatal outcomes and live-birth defects after progestin-primed ovarian stimulation versus conventional ovarian stimulation for in\u00a0vitro fertilization: a large retrospective cohort study","volume":"97","author":"Wang","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib30","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1038\/s41598-017-08472-2","article-title":"Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib31","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s10815-020-01755-0","article-title":"Impact of progestin ovarian stimulation on newborn outcomes: a meta-analysis","volume":"37","author":"Zolfaroli","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib32","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.2147\/DDDT.S210228","article-title":"Neonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for IVF: a retrospective cohort study","volume":"13","author":"Huang","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.fertnstert.2024.01.027_bib33","first-page":"671","article-title":"Progesterone-primed ovarian stimulation in polycystic ovarian syndrome: an RCT","volume":"17","author":"Eftekhar","year":"2019","journal-title":"Int J Reprod Biomed"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502822400030X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001502822400030X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T01:15:17Z","timestamp":1748740517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001502822400030X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S001502822400030X"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2024.01.027","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized controlled trial to compare the live birth rate of the first frozen embryo transfer following the progestin-primed ovarian stimulation protocol vs. the antagonist protocol in women with an anticipated high ovarian response","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2024.01.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92024 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}