{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:50:56Z","timestamp":1791323456919,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032802","name":"Society of Endometriosis and Uterine Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.fertnstert.2025.04.005","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T19:03:17Z","timestamp":1744398197000},"page":"334-343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of clomiphene citrate on multiple gestation births and perinatal outcomes: a nationwide cohort study"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3922-3493","authenticated-orcid":false,"given":"Mathilde","family":"Bourdon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Santulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathana\u00ebl","family":"Beeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathis","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Treluyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Tsatsaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Pinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Chouchana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2025.04.005_bib1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/humupd\/2.6.483","article-title":"Development, pharmacology and clinical experience with clomiphene citrate","volume":"2","author":"Dickey","year":"1996","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0015-0282(16)35647-3","article-title":"Observations on the mechanism of action of clomiphene (MRL-41)","volume":"16","author":"Dickey","year":"1965","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/jpc.12257","article-title":"Perinatal outcomes of intrauterine insemination\/clomiphene pregnancies represent an intermediate risk group compared with in vitro fertilisation\/intracytoplasmic sperm injection and naturally conceived pregnancies","volume":"49","author":"Poon","year":"2013","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib4","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.fertnstert.2014.06.034","article-title":"Perinatal outcomes in 6,338 singletons born after intrauterine insemination in Denmark, 2007 to 2012: the influence of ovarian stimulation","volume":"102","author":"Malchau","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/humrep\/deaa298","article-title":"Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with unexplained subfertility: follow-up of two randomized clinical trials","volume":"36","author":"Wessel","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/ajo.12106","article-title":"Clomiphene ovulation induction and higher-order multiple pregnancy","volume":"53","author":"McDowell","year":"2013","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib7","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJMoa1414827","article-title":"Letrozole, gonadotropin, or clomiphene for unexplained infertility","volume":"373","author":"Diamond","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/1574886311666160627094051","article-title":"Ovarian stimulation, intrauterine insemination, multiple pregnancy and major congenital malformations: a systematic review and meta- analysis- the ART_Rev Study","volume":"11","author":"Chaabane","year":"2016","journal-title":"Curr Drug Saf"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib9","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1080\/14647273.2021.1872803","article-title":"Multiple pregnancy rate in patients undergoing treatment with clomifene citrate for WHO group II ovulatory disorders: a systematic review","volume":"25","author":"Garthwaite","year":"2022","journal-title":"Hum Fertil (Camb)"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.fertnstert.2021.08.030","article-title":"Dispensing of clomiphene citrate to treat infertility: medication supplied and population prevalence of assisted pregnancies and multiple births","volume":"117","author":"Moore","year":"2022","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib11","first-page":"e42257","article-title":"Pregnancy rates in women with polycystic ovary syndrome (PCOS) using letrozole versus clomiphene citrate: a retrospective record review","volume":"15","author":"Bahawi","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2105\/AJPH.92.8.1323","article-title":"The impact of the increasing number of multiple births on the rates of preterm birth and low birthweight: an international study","volume":"92","author":"Blondel","year":"2002","journal-title":"Am J Public Health"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib13","article-title":"Retrospective comparative analysis of neonatal mortality and morbidity in preterm singleton and multiple births - single center experience","volume":"11","author":"Alhasoon","year":"2024","journal-title":"Glob Pediatr Health"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0015-0282(16)58395-2","article-title":"Perinatal outcome of twin pregnancies obtained after in vitro fertilization: comparison with twin pregnancies obtained spontaneously or after ovarian stimulation","volume":"66","author":"Olivennes","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib15","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/pds.5616","article-title":"Trends in clomiphene citrate and gonadotropins use in women with infertility between 2010 and 2017: a population-based study in France","volume":"32","author":"Bourrion","year":"2023","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/jwh.2009.1499","article-title":"Epidemiology of fertility treatment use among U.S. women with liveborn infants, 1997-2004","volume":"19","author":"Duwe","year":"2010","journal-title":"J Womens Health (Larchmt)"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.therap.2023.01.009","article-title":"Performing pharmacoepidemiological studies using the French health insurance data warehouse (SNDS): how to translate guidelines into practice","volume":"78","author":"de Germay","year":"2023","journal-title":"Therapie"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib18","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/pds.4233","article-title":"The national healthcare system claims databases in France, SNIIRAM and EGB: powerful tools for pharmacoepidemiology","volume":"26","author":"Bezin","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib19","doi-asserted-by":"crossref","first-page":"e0295897","DOI":"10.1371\/journal.pone.0295897","article-title":"Trends in harmful drug exposure during pregnancy in France between 2013 and 2019: a nationwide cohort study","volume":"19","author":"Louchet","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jgyn.2015.08.009","article-title":"[Customized and non-customized French intrauterine growth curves. I - methodology]","volume":"45","author":"Ego","year":"2016","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib22","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1007\/s43032-020-00174-x","article-title":"Impact of supraphysiological estradiol serum levels on birth weight in singletons born after fresh embryo transfer","volume":"27","author":"Bourdon","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2458-9-33","article-title":"Ecological association between a deprivation index and mortality in France over the period 1997 - 2001: variations with spatial scale, degree of urbanicity, age, gender and cause of death","volume":"9","author":"Rey","year":"2009","journal-title":"BMC Public Health"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: definition and epidemiology","volume":"62","author":"Vander Borght","year":"2018","journal-title":"Clin Biochem"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ajog.2004.03.040","article-title":"Twins and triplets: the effect of plurality and growth on neonatal outcome compared with singleton infants","volume":"191","author":"Garite","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fertnstert.2008.08.008","article-title":"Strategies to reduce multiple pregnancies due to ovulation stimulation","volume":"91","author":"Dickey","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib27","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/humupd\/dmn034","article-title":"The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis","volume":"14","author":"van Rumste","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib28","first-page":"18","article-title":"Association of the number of follicles of various sizes and treatment protocol with multiple pregnancies following ovulation induction and intrauterine insemination","volume":"58","author":"Moosavifar","year":"2008","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib29","author":"Merviel"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib30","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/humrep\/dead156","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"38","author":"Teede","year":"2023","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/14647273.2018.1535201","article-title":"Ultrasound monitoring during first-cycle treatment with clomifene citrate: a national survey of compliance with NICE","volume":"23","author":"Garthwaite","year":"2020","journal-title":"Hum Fertil (Camb)"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib32","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1471-0528.2007.01559.x","article-title":"Costs of multiple pregnancy","volume":"115","author":"Wood","year":"2008","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib33","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1471-0528.2007.01458.x","article-title":"Costs of NHS maternity care for women with multiple pregnancy compared with high-risk and low-risk singleton pregnancy","volume":"114","author":"Mistry","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/AOG.0000000000003795","article-title":"Mature follicle count and multiple gestation risk based on patient age in intrauterine insemination cycles with ovarian stimulation","volume":"135","author":"Evans","year":"2020","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib35","article-title":"Clomiphene citrate medication for infertility and risk of stillbirth or neonatal death: a population-based cohort study","author":"Moore","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib36","first-page":"829","article-title":"[Recommendations of good practice: medicines that induce ovulation (April 2004)]","volume":"32","year":"2004","journal-title":"Gynecol Obstet Fertil"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/humupd\/dmv029","article-title":"Pregnancy complications in women with polycystic ovary syndrome","volume":"21","author":"Palomba","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib38","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1111\/1471-0528.14651","article-title":"The fetal safety of clomiphene citrate: a population-based retrospective cohort study","volume":"124","author":"Weller","year":"2017","journal-title":"BJOG"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib39","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1111\/1471-0528.14722","article-title":"Clomiphene citrate - a reassuringly safe drug","volume":"124","author":"Afnan","year":"2017","journal-title":"BJOG"},{"issue":"65","key":"10.1016\/j.fertnstert.2025.04.005_bib40","first-page":"e1","article-title":"Stromal cell-specific apoptotic and antiestrogenic mechanisms may explain uterine defects in humans after clomiphene citrate therapy","volume":"203","author":"Nutu","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1078\/0065-1281-00732","article-title":"Expression of glucosamine trisaccharides on the rat uterine surface is altered by clomiphene citrate. III. Relationship with implantation regimes and pregnancy","volume":"105","author":"Hosie","year":"2003","journal-title":"Acta Histochem"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/uog.18933","article-title":"Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta-analysis","volume":"51","author":"Gadalla","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10616-017-0169-1","article-title":"Safety of clomiphene citrate: a literature review","volume":"70","author":"Yilmaz","year":"2018","journal-title":"Cytotechnology"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib44","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1210\/en.2009-0721","article-title":"Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate","volume":"151","author":"Amita","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.fertnstert.2025.04.005_bib45","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s43032-023-01404-8","article-title":"Comparison of letrozole and clomiphene citrate in pregnancy outcomes in patients with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Abu-Zaid","year":"2024","journal-title":"Reprod Sci"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028225002158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028225002158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:08:32Z","timestamp":1791320912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028225002158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0015028225002158"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2025.04.005","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of clomiphene citrate on multiple gestation births and perinatal outcomes: a nationwide cohort study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2025.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92025 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}