{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:50:47Z","timestamp":1791323447277,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702503"],"award-info":[{"award-number":["2022YFC2702503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370917"],"award-info":[{"award-number":["32370917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.fertnstert.2025.04.008","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:54:25Z","timestamp":1744725265000},"page":"297-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preimplantation genetic testing and carrier status detection in patients with balanced chromosomal rearrangements: a real-world multicenter retrospective study"],"prefix":"10.1016","volume":"124","author":[{"given":"Hao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanjun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-zi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-6509","authenticated-orcid":false,"given":"Yingpu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2025.04.008_bib1","first-page":"301","article-title":"The frequency and mutation rate of balanced autosomal rearrangements in man estimated from prenatal genetic studies for advanced maternal age","volume":"35","author":"Van Dyke","year":"1983","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2016.10.013","article-title":"Translocations, inversions and other chromosome rearrangements","volume":"107","author":"Morin","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib3","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.juro.2009.12.004","article-title":"Comprehensive 5-year study of cytogenetic aberrations in 668 infertile men","volume":"183","author":"Yatsenko","year":"2010","journal-title":"J Urol"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib4","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.ajhg.2018.04.005","article-title":"Risks and recommendations in prenatally detected de novo balanced chromosomal rearrangements from assessment of long-term outcomes","volume":"102","author":"Halgren","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.rbmo.2018.03.005","article-title":"Does preimplantation genetic diagnosis improve reproductive outcome in couples with recurrent pregnancy loss owing to structural chromosomal rearrangement? A systematic review","volume":"36","author":"Iews","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib6","first-page":"733","article-title":"[Recurrent aneuploidy in first trimester gestational loss: a case report and review of the literature]","volume":"81","author":"Hern\u00e1ndez-G\u00f3mez","year":"2013","journal-title":"Ginecol Obstet Mex"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000086904","article-title":"Analysis of chromosome segregation during preimplantation genetic diagnosis in both male and female translocation heterozygotes","volume":"111","author":"Munn\u00e9","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s10815-007-9137-6","article-title":"Analysis of meiotic segregation patterns and interchromosomal effects in sperm from six males with Robertsonian translocations","volume":"24","author":"Chen","year":"2007","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/molehr\/gah253","article-title":"Chromosomal segregation in spermatozoa of 14 Robertsonian translocation carriers","volume":"12","author":"Ogur","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib10","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.fertnstert.2008.11.020","article-title":"Translocation chromosome karyotypes of the Robertsonian translocation carriers\u2019 embryos","volume":"93","author":"Jin","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib11","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1472-6483(10)61037-1","article-title":"Preimplantation genetic diagnosis significantly improves the pregnancy outcome of translocation carriers with a history of recurrent miscarriage and unsuccessful pregnancies","volume":"13","author":"Otani","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fertnstert.2009.02.060","article-title":"Preimplantation genetic diagnosis (PGD) improves pregnancy outcome for translocation carriers with a history of recurrent losses","volume":"94","author":"Fischer","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib13","first-page":"89","article-title":"[Preimplantation genetic diagnosis (PGD) of chromosomal aberrations using the fluorescence in situ hybridization method (FISH)--introduction to problems, sampling methods and examination techniques]","volume":"68","author":"Vesel\u00e1","year":"2003","journal-title":"Ceska Gynekol"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.gdata.2014.05.007","article-title":"Using SNP array to identify aneuploidy and segmental imbalance in translocation carriers","volume":"2","author":"Xiong","year":"2014","journal-title":"Genom Data"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib15","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.fertnstert.2010.11.004","article-title":"Single nucleotide polymorphism microarray-based concurrent screening of 24-chromosome aneuploidy and unbalanced translocations in preimplantation human embryos","volume":"95","author":"Treff","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib16","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/humrep\/der082","article-title":"PGD for reciprocal and Robertsonian translocations using array comparative genomic hybridization","volume":"26","author":"Fiorentino","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejogrb.2018.03.013","article-title":"Evaluation of preimplantation genetic testing for chromosomal structural rearrangement by a commonly used next generation sequencing workflow","volume":"224","author":"Chow","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib18","first-page":"315","article-title":"Preimplantation genetic diagnosis by fluorescence in situ hybridization: clinical possibilities and pitfalls","volume":"10","author":"Pehlivan","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10815-012-9727-9","article-title":"Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity","volume":"29","author":"Treff","year":"2012","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s10815-016-0734-0","article-title":"SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts","volume":"33","author":"Treff","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib21","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1093\/humrep\/det271","article-title":"Single-nucleotide polymorphism microarray-based preimplantation genetic diagnosis is likely to improve the clinical outcome for translocation carriers","volume":"28","author":"Tan","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12920-017-0294-x","article-title":"The establishment and application of preimplantation genetic haplotyping in embryo diagnosis for reciprocal and Robertsonian translocation carriers","volume":"10","author":"Zhang","year":"2017","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.fertnstert.2017.07.010","article-title":"Preferential selection and transfer of euploid noncarrier embryos in preimplantation genetic diagnosis cycles for reciprocal translocations","volume":"108","author":"Wang","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ebiom.2016.11.007","article-title":"Reciprocal translocation carrier diagnosis in preimplantation human embryos","volume":"14","author":"Hu","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib25","doi-asserted-by":"crossref","first-page":"E8695","DOI":"10.1073\/pnas.1715053114","article-title":"Mapping allele with resolved carrier status of Robertsonian and reciprocal translocation in human preimplantation embryos","volume":"114","author":"Xu","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.rbmo.2021.09.007","article-title":"Effect of parental origin and predictors for obtaining a euploid embryo in balanced translocation carriers","volume":"44","author":"Tong","year":"2022","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.rbmo.2022.07.016","article-title":"PGT for structural chromosomal rearrangements in 300 couples reveals specific risk factors but an interchromosomal effect is unlikely","volume":"46","author":"Ogur","year":"2023","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib28","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1534\/genetics.120.303656","article-title":"The interchromosomal effect: different meanings for different organisms","volume":"216","author":"Miller","year":"2020","journal-title":"Genetics"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10815-020-02053-5","article-title":"Evaluation of chromosomal abnormalities from preimplantation genetic testing to the reproductive outcomes: a comparison between three different structural rearrangements based on next-generation sequencing","volume":"38","author":"Yuan","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12884-023-06237-6","article-title":"Preimplantation genetic testing in couples with balanced chromosome rearrangement: a four-year period real world retrospective cohort study","volume":"24","author":"Zhou","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12920-015-0110-4","article-title":"Randomized comparison of next-generation sequencing and array comparative genomic hybridization for preimplantation genetic screening: a pilot study","volume":"8","author":"Yang","year":"2015","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib32","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/j.mex.2019.10.028","article-title":"High-resolution mapping of reciprocal translocation breakpoints using long-read sequencing","volume":"6","author":"Chow","year":"2019","journal-title":"MethodsX"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib33","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3389\/fgene.2019.01313","article-title":"Location of balanced chromosome-translocation breakpoints by long-read sequencing on the Oxford nanopore platform","volume":"10","author":"Hu","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib34","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1056\/NEJMc1913370","article-title":"Detection of structural rearrangements in embryos","volume":"382","author":"Madjunkova","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.fertnstert.2025.04.008_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-022-09103-5","article-title":"Nanopore sequencing for detecting reciprocal translocation carrier status in preimplantation genetic testing","volume":"24","author":"Xia","year":"2023","journal-title":"BMC Genomics"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028225002183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028225002183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:07:53Z","timestamp":1791320873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028225002183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0015028225002183"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2025.04.008","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preimplantation genetic testing and carrier status detection in patients with balanced chromosomal rearrangements: a real-world multicenter retrospective study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2025.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92025 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine","name":"copyright","label":"Copyright"}]}}