{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:50:25Z","timestamp":1792702225390,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014849","name":"Valencia Department of Education Culture and Sport","doi-asserted-by":"publisher","award":["CIPROM\/2021\/058"],"award-info":[{"award-number":["CIPROM\/2021\/058"]}],"id":[{"id":"10.13039\/501100014849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI21\/00170"],"award-info":[{"award-number":["PI21\/00170"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.fertnstert.2025.05.143","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:36:31Z","timestamp":1747222591000},"page":"496-505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of bilateral intraovarian platelet-rich plasma in women with poor ovarian response or primary ovarian insufficiency: a retrospective study"],"prefix":"10.1016","volume":"124","author":[{"given":"Pietro","family":"Molinaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ballester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Garcia-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-6922","authenticated-orcid":false,"given":"Sonia","family":"Herraiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2025.05.143_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-0035-1567817","article-title":"Ovarian aging","volume":"33","author":"Seli","year":"2015","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.exger.2014.03.015","article-title":"Greater organ involution in highly proliferative tissues associated with the early onset and acceleration of ageing in humans","volume":"55","author":"Richardson","year":"2014","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(02)09417-5","article-title":"Female subfertility","volume":"360","author":"Evers","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib4","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/humrep\/der092","article-title":"ESHRE consensus on the definition of \u2018poor response\u2019 to ovarian stimulation for in vitro fertilization: the Bologna criteria","volume":"26","author":"Ferraretti","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humupd\/dmr037","article-title":"The poor responder in IVF: is the prognosis always poor?: a systematic review","volume":"18","author":"Oudendijk","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.fertnstert.2007.12.077","article-title":"How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis","volume":"91","author":"Kyrou","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0015-0282(98)00268-4","article-title":"Evaluation of the ovarian reserve in young low responders with normal basal levels of follicle-stimulating hormone using three-dimensional ultrasonography","volume":"70","author":"Pellicer","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/humupd\/dmw006","article-title":"Investigating psychosocial attitudes, motivations and experiences of oocyte donors, recipients and egg sharers: a systematic review","volume":"22","author":"Bracewell-Milnes","year":"2016","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib9","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.fertnstert.2008.07.1769","article-title":"Prognosis of oocyte donation cycles: a prospective comparison of the in vitro fertilization-embryo transfer cycles of recipients who used shared oocytes versus those who used altruistic donors","volume":"92","author":"Oyesanya","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/13697137.2020.1804547","article-title":"Premature ovarian insufficiency: an International Menopause Society White Paper","volume":"23","author":"Panay","year":"2020","journal-title":"Climacteric"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/13697137.2019.1574738","article-title":"The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis","volume":"22","author":"Golezar","year":"2019","journal-title":"Climacteric"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib12","doi-asserted-by":"crossref","first-page":"672890","DOI":"10.3389\/fcell.2021.672890","article-title":"Premature ovarian insufficiency: past, present, and future","volume":"9","author":"Chon","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib13","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/humrep\/deab106","article-title":"Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?","volume":"36","author":"Atkinson","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.arthro.2011.10.018","article-title":"Platelet-rich plasma: a milieu of bioactive factors","volume":"28","author":"Boswell","year":"2012","journal-title":"Arthroscopy"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib15","series-title":"Proceedings of the 32nd Annual Meeting of ESHRE, July 3\u20136, Helsinki, Finland","article-title":"Ovarian rejuvenation and folliculogenesis reactivation in perimenopausal women after autologous platelet-rich plasma treatment","author":"Pantos","year":"2016"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib16","doi-asserted-by":"crossref","first-page":"10211","DOI":"10.18632\/aging.103403","article-title":"Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency","volume":"12","author":"Cakiroglu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib17","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.3390\/jcm9061809","article-title":"Reactivating ovarian function through autologous platelet-rich plasma intraovarian infusion: pilot data on premature ovarian insufficiency, perimenopausal, menopausal, and poor responder women","volume":"9","author":"Sfakianoudis","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib18","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.18632\/aging.203972","article-title":"Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)","volume":"14","author":"Cakiroglu","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoac027","article-title":"Preliminary report of intraovarian injections of autologous platelet-rich plasma (PRP) in extremely poor prognosis patients with only oocyte donation as alternative: a prospective cohort study","volume":"2022","author":"Barad","year":"2022","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s10815-020-01710-z","article-title":"The use of autologous platelet-rich plasma (PRP) versus no intervention in women with low ovarian reserve undergoing fertility treatment: a non-randomized interventional study","volume":"37","author":"Melo","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/humrep\/dew027","article-title":"ESHRE Guideline: management of women with premature ovarian insufficiency","volume":"31","author":"Webber","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib22","doi-asserted-by":"crossref","first-page":"12123","DOI":"10.18632\/aging.206099","article-title":"Intraovarian PRP injection improves oocyte quality and early embryo development in mouse models of chemotherapy-induced diminished ovarian reserve","volume":"16","author":"Cozzolino","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib23","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.fertnstert.2016.07.1068","article-title":"Dual trigger for final oocyte maturation improves the oocyte retrieval rate of suboptimal responders to gonadotropin-releasing hormone agonist","volume":"106","author":"Lu","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.rbmo.2017.04.007","article-title":"Platelet-rich plasma promotes the development of isolated human primordial and primary follicles to the preantral stage","volume":"35","author":"Hosseini","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/13102818.2022.2090280","article-title":"Autologous ovarian platelet rich plasma treatment improves oocyte and embryo quality: a before-after prospective study","volume":"36","author":"Parvanov","year":"2022","journal-title":"Biotechnol Biotechnol Equip"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12958-021-00826-w","article-title":"Evaluation of intra-ovarian platelet-rich plasma administration on oocytes-dependent variables in patients with poor ovarian response: a retrospective study according to the POSEIDON criteria","volume":"19","author":"Farimani","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib27","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/humrep\/deae093","article-title":"Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial","volume":"39","author":"Herlihy","year":"2024","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib28","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/humrep\/deae038","article-title":"Intraovarian platelet-rich plasma injection and IVF outcomes in patients with poor ovarian response: a double-blind randomized controlled trial","volume":"39","author":"Barrenetxea","year":"2024","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib29","doi-asserted-by":"crossref","first-page":"17474","DOI":"10.1073\/pnas.1312830110","article-title":"Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment","volume":"110","author":"Kawamura","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib30","first-page":"e12037","article-title":"A systematic review evaluating the efficacy of intra-ovarian infusion of autologous platelet-rich plasma in patients with poor ovarian reserve or ovarian insufficiency","volume":"12","author":"Panda","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10815-021-02146-9","article-title":"A narrative review of platelet-rich plasma (PRP) in reproductive medicine","volume":"38","author":"Sharara","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib32","doi-asserted-by":"crossref","first-page":"6591717","DOI":"10.1155\/2016\/6591717","article-title":"Platelet-rich plasma: the choice of activation method affects the release of bioactive molecules","volume":"2016","author":"Cavallo","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib33","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1210\/jc.2011-1038","article-title":"Resumption of ovarian function and pregnancies in 358 patients with premature ovarian failure","volume":"96","author":"Bidet","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.fertnstert.2025.05.143_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/cen.13105","article-title":"Long-term outcome of ovarian function in women with intermittent premature ovarian insufficiency","volume":"86","author":"Bachelot","year":"2017","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028225004315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028225004315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:22:24Z","timestamp":1778473344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028225004315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0015028225004315"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2025.05.143","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of bilateral intraovarian platelet-rich plasma in women with poor ovarian response or primary ovarian insufficiency: a retrospective study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2025.05.143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92025 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}