{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:36:05Z","timestamp":1793723765063,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.fertnstert.2026.02.025","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:16:19Z","timestamp":1771604179000},"page":"1079-1087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preimplantation genetic testing for BReast CAncer gene 1 and risk-reducing surgery is more effective at age 35 than age 40"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6292-712X","authenticated-orcid":false,"given":"Kiley","family":"Hunkler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Boedeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelby","family":"Bulles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Combs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2026.02.025_bib1","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1097\/AOG.0000000000002296","article-title":"Practice bulletin No 182: hereditary breast and ovarian cancer syndrome","volume":"130","year":"2017","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/jnci\/djn442","article-title":"Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers","volume":"101","author":"Rebbeck","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib3","first-page":"3","article-title":"Births: final Data for 2023","volume":"74","author":"Osterman","year":"2025","journal-title":"Natl Vital Stat Rep"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib4","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ygyno.2019.06.017","article-title":"Reproductive and hormonal considerations in women at increased risk for hereditary gynecologic cancers: Society of Gynecologic Oncology and American Society for Reproductive Medicine Evidence-Based Review","volume":"155","author":"Chen","year":"2019","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib5","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.fertnstert.2019.09.013","article-title":"Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion","volume":"112","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12958-021-00827-9","article-title":"Preimplantation genetic testing for BRCA gene mutation carriers: a cost effectiveness analysis","volume":"19","author":"Michaan","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib7","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/humrep\/dez203","article-title":"Cost effectiveness of in vitro fertilisation and preimplantation genetic testing to prevent transmission of BRCA1\/2 mutations","volume":"35","author":"Lipton","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib8","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/AOG.0000000000004873","article-title":"Pregnancy at age 35 years or older: ACOG obstetric care consensus no. 11","volume":"140","year":"2022","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib10","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2018.08.032","article-title":"Cost-effectiveness of opportunistic salpingectomy vs tubal ligation at the time of cesarean delivery","volume":"220","author":"Venkatesh","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.fertnstert.2025.01.012","article-title":"Comparing gestational carrier with uterine transplantation in uterine-factor infertility: a cost-effectiveness analysis","volume":"124","author":"Combs","year":"2025","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.fertnstert.2022.03.010","article-title":"In vitro fertilization with preimplantation genetic testing for monogenetic diseases versus unassisted conception with prenatal diagnosis for Huntington disease: a cost-effectiveness analysis","volume":"118","author":"Christensen","year":"2022","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2023.103367","article-title":"Planned oocyte cryopreservation: the state of the ART","volume":"47","author":"Cascante","year":"2023","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib14","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/j.fertnstert.2009.06.027","article-title":"How couples who have undergone in vitro fertilization decide what to do with surplus frozen embryos","volume":"92","author":"Nachtigall","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib15","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.21037\/tau.2019.09.28","article-title":"Fertility preservation options for transgender individuals","volume":"9","author":"Sterling","year":"2020","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib16","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.fertnstert.2021.01.011","article-title":"Planned oocyte cryopreservation-10-15-year follow-up: return rates and cycle outcomes","volume":"115","author":"Blakemore","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.rbmo.2018.11.003","article-title":"Reconceiving egg freezing: insights from an analysis of 5 years of data from a UK clinic","volume":"38","author":"G\u00fcrtin","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12958-022-00996-1","article-title":"Usage and cost-effectiveness of elective oocyte freezing: a retrospective observational study","volume":"20","author":"Yang","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib19","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.fertnstert.2024.07.030","volume":"122","author":"Martel","year":"2024","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ygyno.2018.05.011","article-title":"Age-specific ovarian cancer risks among women with a BRCA1 or BRCA2 mutation","volume":"150","author":"Kotsopoulos","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib22","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ygyno.2008.12.026","article-title":"Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment","volume":"113","author":"Havrilesky","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib25","doi-asserted-by":"crossref","first-page":"e712","DOI":"10.1016\/S2214-109X(15)00069-8","article-title":"Disability weights for the Global Burden of Disease 2013 study","volume":"3","author":"Salomon","year":"2015","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10549-010-1043-4","article-title":"Comparative effectiveness of screening and prevention strategies among BRCA1\/2-affected mutation carriers","volume":"125","author":"Grann","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.contraception.2017.08.003","article-title":"Measuring health utility in varying pregnancy contexts among a diverse cohort of pregnant women","volume":"96","author":"Lundsberg","year":"2017","journal-title":"Contraception"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib29","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1001\/jama.2016.12195","article-title":"Recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses: second panel on cost-effectiveness in health and medicine","volume":"316","author":"Sanders","year":"2016","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib30","doi-asserted-by":"crossref","DOI":"10.1097\/GRH.0000000000000009","article-title":"Female age and assisted reproductive technology","volume":"3","author":"Pierce","year":"2018","journal-title":"Global Reprod Health"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib31","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10815-022-02519-8","article-title":"Combining PGT-A with PGT-M risks trying to do too much","volume":"39","author":"Scriven","year":"2022","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib33","article-title":"ESHRE guideline: female fertility preservation","volume":"4","author":"Anderson","year":"2020","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.fertnstert.2023.03.003","article-title":"Indications and management of preimplantation genetic testing for monogenic conditions: a committee opinion","volume":"120","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib35","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1007\/s10897-018-0264-2","article-title":"Uptake of preimplantation genetic diagnosis in female BRCA1 and BRCA2 mutation carriers","volume":"27","author":"Mor","year":"2018","journal-title":"J Genet Couns"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib36","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1007\/s10815-023-02925-6","article-title":"Preimplantation genetic testing for monogenic disorders: clinical experience with BRCA1 and BRCA2 from 2010-2021","volume":"40","author":"Barrett","year":"2023","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib37","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s10897-017-0069-8","article-title":"\"It was an emotional baby\": previvors' family planning decision-making styles about hereditary breast and ovarian cancer risk","volume":"26","author":"Dean","year":"2017","journal-title":"J Genet Couns"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/gim.0b013e31822ddc7e","article-title":"High-risk consumers' perceptions of preimplantation genetic diagnosis for hereditary cancers: a systematic review and meta-analysis","volume":"14","author":"Quinn","year":"2012","journal-title":"Genet Med"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10689-013-9685-0","article-title":"Comparison of attitudes regarding preimplantation genetic diagnosis among patients with hereditary cancer syndromes","volume":"13","author":"Rich","year":"2014","journal-title":"Fam Cancer"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib40","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/humupd\/dmab013","article-title":"A review on the motivations, decision-making factors, attitudes and experiences of couples using pre-implantation genetic testing for inherited conditions","volume":"27","author":"Hughes","year":"2021","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.rbmo.2017.11.005","article-title":"Professionals' knowledge, attitude and referral behavior of preimplantation genetic diagnosis for hereditary breast and ovarian cancer","volume":"36","author":"Gietel-Habets","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2026.02.025_bib42","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.fertnstert.2010.03.064","article-title":"BRCA carriers' thoughts on risk management in relation to preimplantation genetic diagnosis and childbearing: when too many choices are just as difficult as none","volume":"94","author":"Quinn","year":"2010","journal-title":"Fertil Steril"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028226001160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028226001160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:29:15Z","timestamp":1780939755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028226001160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0015028226001160"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2026.02.025","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preimplantation genetic testing for BReast CAncer gene 1 and risk-reducing surgery is more effective at age 35 than age 40","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2026.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92026 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine","name":"copyright","label":"Copyright"}]}}