{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:02:34Z","timestamp":1784768554584,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,22]],"date-time":"2027-06-22T00:00:00Z","timestamp":1813622400000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA21765"],"award-info":[{"award-number":["P30 CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA195547"],"award-info":[{"award-number":["U01 CA195547"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.fertnstert.2026.03.023","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:08:05Z","timestamp":1774051685000},"page":"57-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Semen parameters in unirradiated, alkylating agent\u2013exposed childhood cancer survivors in the St. Jude Lifetime Cohort Study"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-5410","authenticated-orcid":false,"given":"Daniel M.","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendrick","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond W.","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Delaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine H.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Bjornard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeoKumar","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Kutteh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyla C.","family":"Shelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhant","family":"Taneja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie L.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2026.03.023_bib1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ijrobp.2023.08.010","article-title":"Testicular dysfunction in male childhood cancer survivors treated with radiation therapy: a PENTEC comprehensive review","volume":"119","author":"Baliga","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib3","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/S1470-2045(20)30582-9","article-title":"Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group","volume":"22","author":"Mulder","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib4","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1016\/S1470-2045(17)30026-8","volume":"18","author":"Skinner","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/pbc.24679","article-title":"The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure. A report from the Childhood Cancer Survivor Study","volume":"61","author":"Green","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib6","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/humupd\/dmaa041","article-title":"Impacts of platinum-based chemotherapy on subsequent testicular function and fertility in boys with cancer","volume":"26","author":"Tian En","year":"2020","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib7","series-title":"4th International Symposium on Late Complications after Childhood Cancer Seattle","article-title":"Risk factors for azoospermia and testosterone deficiency among survivors of childhood cancer in the Netherlands: results of the DCCSS-LATER 2 Study","author":"Claessens","year":"2025"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib8","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S1470-2045(14)70408-5","article-title":"Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study","volume":"15","author":"Green","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib9","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1158\/1055-9965.EPI-16-0812","article-title":"Approach for classification and severity-grading of long-term and late-onset health events among childhood cancer survivors in the St. Jude Lifetime Cohort","volume":"26","author":"Hudson","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/pbc.22875","article-title":"Prospective medical assessment of adults surviving childhood cancer: study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort Study","volume":"56","author":"Hudson","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib11","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/pbc.24348","article-title":"Assessment of potential bias from non-participation in a dynamic clinical cohort of long-term childhood cancer survivors: results from the St. Jude Lifetime Cohort Study","volume":"60","author":"Ojha","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib12","series-title":"The children\u2019s oncology group long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers","year":"2013"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/mpo.1316","article-title":"Study design and cohort characteristics of the Childhood Cancer Survivor Study: a multi-institutional collaborative project","volume":"38","author":"Robison","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib14","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1200\/JCO.2015.61.5187","article-title":"Equivalence ratio for daunorubicin to doxorubicin in relation to late heart failure in survivors of childhood cancer","volume":"33","author":"Feijen","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib15","first-page":"864","article-title":"Derivation of anthracycline and anthraquinone equivalence ratios to doxorubicin for late-onset cardiotoxicity","volume":"5","author":"Feijen","year":"2019","journal-title":"J Am Med Assoc Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0305-7372(85)90019-2","article-title":"High dose cisplatin and high dose carboplatin in refractory ovarian cancer","volume":"12","author":"Ozols","year":"1985","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib17","series-title":"WHO laboratory manual for the examination and processing of human semen","year":"2010"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib18","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF01129567","article-title":"Accuracy of sperm characteristics in predicting the in vitro fertilizing capacity of semen","volume":"5","author":"Comhaire","year":"1988","journal-title":"J In Vitro Fert Embryo Transf"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib19","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/j.1939-4640.1996.tb01832.x","article-title":"Evaluation of the effect of the absence of sperm with rapid and linear progressive motility on subsequent pregnancy rates following intrauterine insemination or in vitro fertilization","volume":"17","author":"Bollendorf","year":"1996","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0378-3758(96)00091-2","article-title":"Continuity corrected approximations for and \u2018exact\u2019 inference with Pearson\u2019s c2","volume":"59","author":"Mudholkar","year":"1997","journal-title":"J Stat Plan Inference"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib21","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1002\/cncr.34971","article-title":"Therapeutic exposures and pubertal testicular dysfunction are associated with adulthood milestones and paternity after childhood cancer","volume":"129","author":"Korhonen","year":"2023","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/BF02002903","article-title":"Gonadal function of young adults after therapy of malignancies during childhood or adolescence","volume":"155","author":"M\u00fcller","year":"1996","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2605.2010.01058.x","article-title":"High risk of azoospermia in men treated for childhood cancer","volume":"34","author":"Romerius","year":"2011","journal-title":"Int J Androl"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/00043426-200304000-00005","article-title":"Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma","volume":"25","author":"Longhi","year":"2003","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib25","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1002\/1097-0142(19921201)70:11<2703::AID-CNCR2820701123>3.0.CO;2-X","article-title":"Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing and soft tissue sarcomas","volume":"70","author":"Meistrich","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/1097-0142(20010201)91:3<613::AID-CNCR1042>3.0.CO;2-R","article-title":"High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood","volume":"91","author":"Kenney","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.reprotox.2006.04.020","article-title":"Progress in the development of childhood cancer therapy","volume":"22","author":"Garolla","year":"2006","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cncr.35623","article-title":"Longitudinal trends in testicular volume z scores from puberty to adulthood, sperm quality, and paternity outcomes after childhood cancer","volume":"131","author":"Korhonen","year":"2025","journal-title":"Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/oxfordjournals.annonc.a058840","article-title":"Dose-dependent impairment of testicular function in patients treated with cisplatin-based chemotherapy for germ cell cancer","volume":"5","author":"Petersen","year":"1994","journal-title":"Ann Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib30","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/bjc.2012.471","article-title":"Sperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular cancer","volume":"107","author":"Brydoy","year":"2012","journal-title":"Br J Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib31","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1007\/s00432-013-1527-9","article-title":"Impact of chemotherapy and radiotherapy in childhood on fertility in adulthood: the FeCt-survey of childhood cancer survivors in Germany","volume":"139","author":"Reinmuth","year":"2013","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2013.05.018","article-title":"Impact of chemotherapy and radiotherapy for testicular germ cell tumors on spermatogenesis and sperm DNA: a multicenter prospective study from the CECOS network","volume":"100","author":"Bujan","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fphar.2016.00122","article-title":"Impact of BEP or carboplatin chemotherapy on testicular function and sperm nucleus of subjects with testicular germ cell tumor","volume":"7","author":"Ghezzi","year":"2016","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00418-006-0168-3","article-title":"Sertoli cell function in albino rats treated with etoposide during prepubertal phase","volume":"126","author":"Stumpp","year":"2006","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib35","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ar.a.20045","article-title":"Apoptosis and testicular alterations in albino rats treated with etoposide during the prepubertal phase","volume":"279","author":"Stumpp","year":"2004","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib36","series-title":"Product monograph: etoposide injection (etoposide injection, Teva standard)","first-page":"22","year":"2016"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib37","series-title":"Bristol Myers Squibb Canada","first-page":"27","article-title":"Product Monograph Vumon (teniposide)","year":"2011"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib38","series-title":"Germ Cell Tumours III","first-page":"337","article-title":"Late side effects in patients treated for testicular cancer","author":"Aass","year":"1994"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib39","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/0277-5379(91)90166-B","article-title":"Combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for metastatic testicular teratoma: long-term follow-up","volume":"27","author":"Dearnaley","year":"1991","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/oxfordjournals.humrep.a019007","article-title":"Sperm morphology assessment using strict criteria and male fertility under in-vivo conditions of conception","volume":"11","author":"Eggert-Kruse","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib41","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000082368","article-title":"The use of semen parameters to identify the subfertile male in the general population","volume":"59","author":"van der Merwe","year":"2005","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/j.1939-4640.2000.tb03284.x","article-title":"Semen quality and human fertility: a prospective study with healthy couples","volume":"21","author":"Zinaman","year":"2000","journal-title":"J Androl"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib43","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2605.1988.tb01011.x","article-title":"Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics","volume":"11","author":"Jouannet","year":"1988","journal-title":"Int J Androl"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib44","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/humrep\/15.7.1562","article-title":"Computer-assisted semen analysis parameters as predictors for fertility of men from the general population. The Danish First Pregnancy Planner Study Team","volume":"15","author":"Larsen","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1200\/JCO.2009.24.9037","article-title":"Fertility of male survivors of childhood cancer. A report from the Childhood Cancer Survivor Study","volume":"28","author":"Green","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib46","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1200\/JCO.2011.38.6938","article-title":"Male reproductive health after childhood, adolescent, and young adult cancer: a report from the Children's Oncology Group","volume":"30","author":"Kenney","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.fertnstert.2026.03.023_bib47","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1200\/JCO-24-02782","article-title":"Fertility preservation in people with cancer: ASCO Guideline Update","volume":"43","author":"Su","year":"2025","journal-title":"J Clin Oncol"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028226001755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028226001755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:39:14Z","timestamp":1784767154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028226001755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0015028226001755"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2026.03.023","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Semen parameters in unirradiated, alkylating agent\u2013exposed childhood cancer survivors in the St. Jude Lifetime Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2026.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92026 American Society for Reproductive Medicine, Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}